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The US Office of the Director of National Intelligence recently released its annual threat assessment, in which Iran is mentioned no fewer than 60 times as part of a “diverse array of threats” facing the US. Iran is moving toward its goal of full domination of Iraq and the expulsion of the last remaining US forces from that country, a result that would represent a great success for the Islamic Rep
In severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) is a life-prolonging treatment, especially among COVID-19 patients. Evaluation of lung injury progression is challenging with current techniques. Diagnostic imaging or invasive diagnostics are risky given the difficulties of intra-hospital transportation, contraindication of biopsies, and the potential
Acute myeloid leukemia (AML) is defined by an accumulation of immature myeloid blasts in the bone marrow. To identify key dependencies of AML stem cells in vivo, here we use a CRISPR-Cas9 screen targeting cell surface genes in a syngeneic MLL-AF9 AML mouse model and show that CXCR4 is a top cell surface regulator of AML cell growth and survival. Deletion of Cxcr4 in AML cells eradicates leukemia c
OBJECTIVE: The aim of this study was to investigate if there is a causal relationship between circulating levels of TIM-1 (T-cell immunoglobulin and mucin domain 1) and incidence of stroke. Approach and Results: Plasma TIM-1 was analyzed in 4591 subjects (40% men; mean age, 57.5 years) attending the Malmö Diet and Cancer Study. Incidence of stroke was studied in relation to TIM-1 levels during a m
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34+ CD38low chronic phase CML cells. Out of the 313 unique human cytokines evaluated, 11 were found to ex
Risk-based inspection (RBI) planning is concerned with the optimal allocation of deterioration control which is based on the pre-posterior analysis using the Bayesian decision theory and the expected utility theory. It has been widely used to make inspection and repair strategy in the field of civil engineering and infrastructure systems. Nowadays, with the developments of sensing and inspection t
Macrophages are a functionally heterogeneous group of immune cells abundant in atherosclerotic plaques. Macrophages expressing CD163 are associated with intraplaque hemorrhage and have previously been considered atheroprotective. However, in a recent study CD163-deficient atherosclerotic ApoE−/− mice exhibited smaller and less complex plaques, suggesting a proatherogenic role of CD163. Previous sm
Smart cameras are increasingly used in surveillance solutions in public spaces. Contemporary computer vision applications can be used to recognize events that require intervention by emergency services. Smart cameras can be mounted in locations where citizens feel particularly unsafe, e.g., pathways and underpasses with a history of incidents. One promising approach for smart cameras is edge AI, i
Climate change has the potential to alter hydrological regimes and to expand saturated areas in permafrost environments, which are important sources of organic carbon. The sources, transfer zones, and delivery mechanisms of carbon into the stream network are controlled by the morphometric properties of the catchment; however, the utility and limitations of these properties as predictors of dissolv
Lagen (1982:80) om anställningsskydd (LAS) genomgick år 2022 en reform som bland annat innebar en förändring av regleringen för uppsägning på grund av personliga skäl i 7 § LAS. Syftet var att öka förutsebarheten för både arbetsgivare och arbetstagare vid uppsägningar. Med hjälp av rättsdogmatisk metod syftar uppsatsen till att analysera och kartlägga reformen i förhållande till uppsägning på gruThe Employment Protection Act (LAS) underwent a reform in 2022 which, among other things, involved a change in the regulation regarding dismissals on personal grounds in Section 7. The purpose of the reform was to increase predictability for both employers and employees in cases of dismissals. Using a legal dogmatic method, the thesis aims to analyse and map the reform in relation to dismissal on
With the world facing severe ecological degradation, we hear calls for radical change more and more often. One of these calls is for degrowth in materially wealthy nations, including the Nordics. Degrowth fundamentally challenges the modern assumption that economic growth is good for humanity and the planet, and therefore necessitates change in civil society, state and production. In the contempor
BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H
Controlling the streaming flow in acoustically actuated microchannels enables the targeted motion of suspended micro-objects. This can offer novel approaches for rare cell studies or cell sorting in medicine or basic biology. In this work, we utilize the temperature dependence of the acoustic body force, which originates from the interaction of an acoustic field with gradients in compressibility o
Determining the land cover (LC) data requirements used as input to noise simulations is essential for planning sustainable urban densifications. This study examines how different LC datasets influence simulated environmental noise levels of road traffic using Nord2000 in an urban area of 1 km2 in southern Sweden. Four LC datasets were used. The first dataset was based on satellite data (spatial re
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that RORγt+ DCs are a co
Background: Cognitive rigidity and working memory impairment are established features of internalizing syndromes. Growing evidence suggests that deficits in affective control –cognitive control in the context of emotion – may underpin elevated emotion-related impulsivity in various psychiatric disorders. Objective: This study examines two components of affective control (affective flexibility and
