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Red blood cell (RBC) traits are important heritable clinical biomarkers and modifiers of disease severity. To identify coding genetic variants associated with these traits, we conducted meta-analyses of seven RBC phenotypes in 130,273 multi-ethnic individuals from studies genotyped on an exome array. After conditional analyses and replication in 27,480 independent individuals, we identified 16 new
OBJECTIVES: Post-stroke cognitive impairment (PSCI) has considerable impact on patients and society. However, long-term studies on PSCI are scarce and may be influenced by assessment methods and selection bias. We aimed to (i) assess the prevalence of long-term PSCI; (ii) compare two common cognitive assessment instruments; and (iii) compare cognitive function of long-term stroke survivors with no
The European Union plays a globally influential role in environmental legislation, with policies and regulation rooted in particular norms. Through a narrative on regulatory capitalism, ecological modernization, and diffusion, we trace how the promotion of renewable energy in transport through subsidies, mandatory targets, and prescriptive criteria for liquid biofuels mobilize social forces for it
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of mesDA neuron development. Here, we studied this process using transcriptome-wide single-cell RNA sequencing of mouse neural progenitors expressing the
Popular Abstract in Swedish Avhandlingen handlar om hur fett (lipider) i kosten bryts ner och transporteras i blodet för att slutligen antingen användas som energi, byggstenar i cellväggarna eller lagras i fettväven. I den här avhandlingen kan man också läsa om hur man kan modifiera fetter med hjälp av speciella proteiner: enzymer för att förbättra näringsinnehållet och dess fysikaliska egenskaperAn important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly
This paper presents a new automatic algorithmfor extracting properties of an individual artist’sstyle and applying those properties to other drawings.The algorithm can be used to ensure consistent artisticstyle across a project by automatically transferringa selected style to hand drawn images. We present analgorithm that uses multiple stages; subdivision of animage into selected geons, extraction
The present thesis investigated Swedish nouns differing in concreteness, specificity and emotional content using linguistic, psycholinguistic and neurolinguistic methods. The focus of Paper I was a semantic analysis of discourse produced by a person with a lesion in visual (left occipital) cortex. The results showed that the lesion site was related to with problems processing concrete nouns relateThe present thesis investigated Swedish nouns differing in concreteness, specificity and emotional content using linguistic, psycholinguistic and neurolinguistic methods. The focus of Paper I was a semantic analysis of discourse produced by a person with a lesion in visual (left occipital) cortex. The results showed that the lesion site was related to with problems processing concrete nouns relate
Popular Abstract in Swedish Cerebral pares (CP) drabbar drygt 2 barn per 1000 födda och är den vanligaste orsaken till rörelsehinder hos barn och ungdomar. På latin betyder CP "förlamning från hjärnan" och är ett samlingsnamn för ett följdtillstånd efter en skada i den omogna hjärnan under dess utveckling från fosterstadiet t o m 2-års ålder. Skadan är av engångskaraktär men de olika symtomen föräCerebral palsy (CP) is a term for a group of conditions associated with motor disabilities, that are very heterogeneous, i.e. symptoms, severity, associated impairments, functional outcome and needs. The overall purpose of this thesis was to study the prevalence and gross motor function and to evaluate and adapt measurements in children with CP. The prevalence in Southern Sweden was 2.4 per 1000 c
This self-study documents two teacher educators’ professionalinquiry into the notions of critical friendship. Specifically, we asked:How does our interactive inquiry on the topic of critical friendshiplead us to new understandings of critical friends? Three theoreticalperspectives framed this study – More Knowledgeable Others,Thought Collective, and reflection. Data sources included (a) artifactsfThis self-study documents two teacher educators’ professional inquiry into the notions of critical friendship. Specifically, we asked: How does our interactive inquiry on the topic of critical friendship lead us to new understandings of critical friends? Three theoretical perspectives framed this study – More Knowledgeable Others, Thought Collective, and reflection. Data sources included (a) artif
Abstract Background: Advanced paediatric surgery is increasingly centralised in Sweden in order to improve treatment outcomes and reduce surgical risks. However, the overall need for surgery in the paediatric population has not been estimated, and the association between geographic access to surgical facilities and timely treatment for common surgical conditions in children is largely unknown.
Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective and associated with severe side effects, disease-specific therapies are urgently needed. We hypothesized that druggable molecular
Background: Breathlessness, the subjective sensation of breathing discomfort, is common and appears in the daily life of people with cardiorespiratory diseases. Physicians often rely on patient's history based on symptom recall. The relation between recalled and experienced breathlessness is still poorly understood. This paper presents the protocol for a study primarily aimed at evaluating the rel
The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related g
OBJECTIVE: Gestational diabetes mellitus (GDM) is a transient form of diabetes characterized by impaired insulin secretion and action during pregnancy. Population-based differences in prevalence exist which could be explained by phenotypic and genetic differences. The aim of this study was to examine these differences in pregnant women from Punjab, India and Scandinavia.METHODS: 85 GDM/T2D loci in
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma r
Background and Aims The island of Gotland in the Baltic Sea had no contact with surrounding continental areas since the withdrawal of the Weichselian ice sheet at ca 17 ka BP. Plants present on Gotland must have arrived by long distance dispersal, so populations are expected to exhibit reduced levels of genetic diversity compared with surrounding mainlands. However, orchids have very small seeds, Background and AimsThe island of Gotland in the Baltic Sea has had no contact with surrounding continental areas since the withdrawal of the Weichselian ice sheet at approx. 17 ka BP. Plants present on Gotland must have arrived by long-distance dispersal, so populations are expected to exhibit reduced levels of genetic diversity compared with populations on surrounding mainlands. However, orchids
Popular AbstractInformationsteknologins utveckling medför att gränserna mellan data, tele- och mediateknik suddas ut. Kommunikation mellan individer, mellan individer och företag och mellan olika nätverk ger möjlighet att snabbt överföra information och kunskap från en plats till en annan oavsett geografiskt avstånd. Detta innebär att nya arbete och verksamheter skapas i arbetslivet. En del är möjThe purpose of this study is to analyse the situation of living and working for women who are teleworking in their homes. Telework carried out in the home will mean that paid and unpaid work will be done in the same location. When this happens, the division of time and space between paid and unpaid work is no longer self-evident, contraty to what appears to be the case when the workplace and the h
The doubly magic nucleus 100Sn represents a crucial test for the nuclear shell model, which is a widely used model for a quantitative description of nuclei. Excited states in 100Sn are experimentally not accessible with present day techniques, but it is possible to gain insight into its structure by studying the properties of excited states of neighboring nuclei. These nuclei
