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Background: Late effects of polio (LEoP) are defined as new symptoms, for example, muscle weakness, fatigue, and pain, occurring many years after an acute polio infection. These impairments can lead to difficulties performing everyday activities (ie, activity limitations) that can reduce a person's ability to take part in society (ie, perceived participation restrictions). Yet, no study has explor
Objectives: To assess level of degeneration in human knee cartilage and meniscus in donors without clinically-evident knee arthritis, in relation to age and sex. Further, to investigate the association between cartilage and meniscus degeneration. Design: Histological sections of knee cartilage and meniscus from 44 deceased donors (ages 18–85 years) without clinically-evident osteoarthritis or infl
We have previously found using questionnaire/interview data on COVID-19 outcomes, that most subjects with severe alpha-1-antitrypsin deficiency (AATD) exhibit mild COVID-19 infection and those who additionally have COPD are at increased risk of severe COVID-19. We used objective information on COVID-19 outcomes in severe AATD (PiZZ) from the Swedish population and compared the risk of severe COVID
Wetting and dewetting dynamics in aqueous solutions containing amphiphilic compounds involve intricate interactions that influence contact angles and surface tension, with broad implications in materials science and biology. This study explores the dynamics of wetting and dewetting on glass surfaces in aqueous media containing the amphiphilic compound C18OE84, focusing on capillary rise behavior.
Klebsiella pneumoniae is a major opportunistic pathogen, where the polysaccharide capsule is traditionally recognized as a critical virulence determinant. However, its role in surface interactions and intracellular adaptation remains incompletely understood. Here, we combined phenotypic assays with physicochemical analyses to dissect the contribution of the capsule. A wza knockout mutant displ
Objective: So-called responder analyses are commonly used in randomized controlled trials (RCT) for osteoarthritis and are typically based on observed change from baseline in self-reported pain. However, it is well known in the methodological literature that such responder analyses are misleading. We aimed to illustrate the size of the problem using simulation. Design: We generated individual pain
The production of neuroepithelial stem (NES) cells, a promising therapeutic candidate for neurological conditions such as stroke and spinal cord injuries, faces significant manufacturing challenges, particularly in quality control (QC). Specifically, current QC methods rely on labor-intensive manual assessments that are costly, time-consuming, and subject to operator bias, limiting scalability and
Despite rapid clinical translation, induced pluripotent stem cell (iPSC)-derived therapies face limited global adoption. Harmonized quality control (QC) remains absent, with even fundamental parameters evaluated inconsistently across laboratories. To address this, we conducted two international Quality Assessment Rounds (QARs): QAR 2019 (18 sites, 11 countries) and QAR 2023 (23 sites, 12 countries
Articular cartilage undergoes structural and compositional changes during osteoarthritis (OA), one of the most common joint diseases. Earlier research shows that these changes are dependent on species and joint site, and they also vary across cartilage depth. In this study, we analyzed the depth-wise proteoglycan and collagen contents, as well as collagen fibril orientation angle and fibril alignm
Ordered assemblies of colloidal semiconductor nanocrystals have traditionally been studied for energy transfer and electronic transport arising from wavefunction overlap between neighboring nanocrystals. In this perspective, we instead focus on light-coupled nanocrystal solids engineered primarily for light emission. These materials include ordered superlattices and compositionally doped assemblie
Background: Chronic pain in children can significantly impact daily functioning. While interdisciplinary pain rehabilitation is the recommended treatment, it is resource-intensive and limited in availability. Therefore, children with more complex symptoms, classified as High Impact Chronic Pain (HICP), need to be prioritized for interdisciplinary pain rehabilitation. However, HICP in children has
Background: Obesity and type 2 diabetes (T2DM) are considered risk factors for complications following total hip arthroplasty (THA). How these risk factors separately or in combination influence the risk of reoperation due to periprosthetic joint infection (PJI) or all-cause reoperation is not fully known. We sought to investigate the 2-year risk of reoperation following THA due to osteoarthritis
BACKGROUND: Obesity is a major risk factor for dyslipidemia, but this relationship is highly variable. Recently published data from 2 Danish cohorts suggest that genetic factors may underlie some of this variability.METHODS AND RESULTS: We tested whether established triglyceride-associated loci modify the relationship of body mass index (BMI) and triglyceride concentrations in 2 Swedish cohorts (t
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer a
Since the discovery of short, regulatory microRNAs (miRNA) 20 years ago, the understanding of their impact on gene regulation has dramatically increased. Differentiation of cells requires comprehensive changes in regulatory networks at all levels of gene expression. Posttranscriptional regulation by miRNA leads to rapid modifications in the protein level of large gene networks, and it is therefore
Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium i
MafA is a key transcriptional activator of islet beta cells and its exclusive expression within beta cells of the developing and adult pancreas is distinct amongst pancreatic regulators. Region 3 (base pairs -8118/-7750 relative to the transcription start site), one of six conserved 5' cis-domains of the MafA promoter, is capable of directing beta-cell-line-selective expression. Transgenic reporte
To evaluate pre-arrest morbidity score (PAM), prognosis after resuscitation score (PAR) and to identify additional clinical variables associated with survival after in-hospital cardiac arrest (IHCA) treated with cardiopulmonary resuscitation (CPR).
Transplantation of hematopoietic stem cells (HSCs) to treat hematological disorders is routinely used in the clinic. However, HSC therapy is hindered by the requirement of finding HLA-matched donors, as well as attaining sufficient numbers of long-term HSCs in the graft. Therefore, ex vivo expansion of transplantable HSC remains one of the "holy grails" of hematology. Without the ability to mainta
The Selvester QRS scoring system has previously been shown to enable estimation of myocardial infarct (MI) size by quantitative evaluation of the 12-lead ECG. The aim of this study was to assess the system's ability to detect and quantify lateral MI, using cardiac magnetic resonance (CMR) as reference standard.
