Filetype
Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data
sing an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of
Rationale: Atherosclerotic plaques that give rise to acute clinical symptoms are typically characterized by degradation of the connective tissue and plaque rupture. Experimental studies have shown that mechanisms to repair vulnerable lesions exist, but the rate of remodeling of human plaque tissue has not been studied. Objective: In the present study, we determined the biological age of different
The indirect environmental impacts of industries or policies caused by the activities of a supply chain were sometimes neglected, although the prevention of direct impacts from industries was addressed and several measures were taken. IO approach is a powerful tool to analyze the activities in a supply chain. Industrial interdependence analysis and EIO LCA, which are IO approaches, are applied in
Ett icke-lagstadgat undantag från upphovsrätten är det s.k. parodiundantaget som kommit att utläsas ur förarbeten till URL och svensk rättspraxis. Parodier har kommit att betraktas som nya och självständiga verk i svensk rätt och har därför sammankopplats med 4 § andra stycket URL. Pastischer har inte uttryckligen nämnts i äldre svenska förarbeten eller svensk rättspraxis, men har antagits inkludeA non-statutory exception to copyright is the so-called parody exception, which have been inferred from legislative history of the Swedish Act on Copyright in Literary and Artistic Works and Swedish case-law. Parodies have come to be regarded as new and independent works in Swedish law and have therefore been linked to Section 4(2) of the Swedish Act on Copyright in Literary and Artistic Works. It
The aim of this study was to analyze the experiences of professionals within certain Social services working with people seeking help for an unwanted sexuality. This unwanted sexuality can involve buying sex, experiencing loss of control in sexual context and/or unwanted sexual fantasies. In contrast to other studies in this subject, which often debates the professionals experiences of working the
Uppsatsen syftar till att nyansera massmedias och myndigheters kritiska bild av HVB-hemmen och undersöka personalens behandlingsarbete, samt vad som påverkar behandlingens utfall. Empirin består av semistrukturerade intervjuer med anställda på HVB-hem, som analyserats tematiskt med tidigare forskning och teorierna: differentiella associationer, sociala band och rollteori. Resultatet visade att det
Objective To compare longitudinal speech outcomes at ages 5 and 10 years in foreign-born and Swedish-born children with cleft palate with or without cleft lip (CP ± L), and assess impact of cleft type, additional diagnosed conditions, sex, and age at completed primary palatal surgery.DesignLongitudinal, registry-based cohort study.SettingRegional public care university hospitals in Sweden.Particip
Ageing in the human brain is a major risk factor for most neurodegenerative diseases. Yet the cell-type-specific molecular changes that contribute to this risk remain poorly understood. This thesis investigates cell-type-specific changes across multiple levels of molecular regulation and their roles in physiological and pathophysiological brain ageing. Using single-nucleus RNA sequencing of postmo
Several factors contribute to the use, non-use, or inadequate use of personal protective equipment (PPE) in construction work. This study aimed to analyse correct usage of various PPE, such as helmet, ear protectors, goggles, respiratory mask, gloves, protective clothing, and a safety harness. Correct usage was assessed as guessability, which refers to human perceptions of how to don, adjust, use,
Background: – Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children, and results in kidney failure in up to one third of cases. There is very limited knowledge on kidney transplantation in childhood-onset AAV. We assessed kidney transplantation outcomes and prognostic factors in a multicentre cohort of patients with childhood-onset AAV.Methods: – Patients diag
In recent years, the automotive industry has increasingly prioritized comfort to meet rising consumer expectations for luxurious car experiences. Comfort, a subjective concept associated with well-being and relaxation, encompasses multidimensional aspects rooted in physical, psychological, and functional aspects. While existing comfort models focus mainly on seated positions and sensations like fa
The energy system is undergoing significant changes and is expected to continue to evolve. Energy demand is anticipated to increase, as is renewable energy capacity, and technical solutions are advancing. For electrical power, traditionally centralized production is increasingly complemented by distributed production, transforming fundamental system functionality. These developing factors will aff
Background: Severe Alpha-1-Antitrypsin deficiency (AATD), phenotype PiZZ, is a leading cause of liver disease in neonates, children, and adults. Nevertheless, the prevalence of liver disease and mortality within PiZZ adults remains unclear. Between 1972 and 1974, a cohort of 129 individuals with severe AATD (PiZZ) was identified through the Swedish national screening of 200,000 newborns. The cohor
