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Nearly 40 % of individuals will be diagnosed with cancer in their lifetime, translating to an estimated 20 million new cases annually. Despite remarkable therapeutic advances, only 15–20 % of patients achieve durable responses to immunotherapy, and the high cost of treatment (illustrated by immune checkpoint inhibitors like pembrolizumab and nivolumab, totaling roughly $191,000 per year) remains a
The green transition relies on metals, requiring increased metal recovery from waste. However, exposure risks among metal recycling workers are poorly understood. We conducted a cross-sectional study to assess dust and metal exposure among 139 recycling workers from 13 Swedish metal recycling companies and 90 controls. We documented work practices through observations and questionnaires and assess
Abstract: The breast cancer long-term survival rate has improved; early detection of local recurrence and second primary cancers has been crucial to this success. Mammography is the standard imaging technique for follow-up, but its sensitivity is affected by breast density and post-treatment changes. This article discusses the role of mammography in the follow-up of women after breast cancer treat
Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionna
The medical profession plays a crucial role in tackling the health impacts of climate change and in promoting a green transition of society and the health sector. Despite this, opportunities for action are still quite unknown within the profession, and no mandatory education is required in interns' or residents' education. Medical schools, on the contrary, both in Sweden (due to legislation) and a
Background: Dihydrotestosterone (DHT), the most potent ligand to the androgen receptor, is synthesised from testosterone (T) by 5α-reductase type 1 and 2. While type 1 is expressed in several non-reproductive tissues in both sexes, men also express high levels of the high-affinity type 2 isoform in reproductive tissues; yet women have a higher circulating DHT to T (DHT/T) ratio than men. We hypoth
In Acoustofluidics, sound pressure waves can cause a force field on the liquid in a microfluidic channel. The forces depend on density and compressibility of the medium as well as the pressure and velocity amplitude of the sound. The forces lead to a steady flow in the bulk of the fluid, namely acoustic streaming. If a localized change in temperature introduces a gradient in compressibility and de
The role of long non-coding RNAs (lncRNAs) in early mammalian embryogenesis remains unclear due to the complexity of the regulatory mechanisms involving lncRNAs and the limited availability of embryo samples. Stem cell-based models, such as mouse gastruloids, provide new ways to address these challenges. Here, we investigate the function of ultra-conserved lncRNA T-UCstem1 in mammalian body plan f
The Unified Glare Rating (UGR) method defined by the International Commission on Illumination is practically the only one used for evaluation of discomfort glare in the lighting design process. However, it is unclear if this method aligns with subjective discomfort glare measures using subjective glare indexes (SGIs). We compared calculated UGR values with commonly used subjective discomfort glare
Magnetic Weyl semimetals have emerged as a fertile ground for exploring quantum phases of matter and quasiparticles. The latter includes unconventional fermions with larger Chern numbers than those of conventional Weyl fermions and topologically nontrivial band structures in bosonic excitations. They hold potential for further experimental exploration of emergent quantum matter, magnon-polarons, w
The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, c
Traffic-related air pollution has severe implications for our health and stringent emission legislation is being enforced to traffic emissions, for example in the EU, USA, and China. With stricter emission legislation (next is EURO 7) and a rapid growth of battery electrical vehicles (BEVs) the combustion-derived pollutants emitted from the tailpipe are decreasing. However, heavier vehicles have r
Comparison of ROS production of individual particle components from traffic-related sources can inform new health policies and emissions legislation. This work aims to quantify acellular ROS production and oxidative potential (OP) of such individual particle components from combustion, brake, tire, and road wear. Particle characteristics are probed to identify source-specific markers and improve t
Background: Late effects of polio (LEoP) is a progressive condition leading to a lifelong disability that can affect mental health. There is limited knowledge of depressive symptoms and associated factors in people with LEoP. Objective: To assess the occurrence of depressive symptoms in people with LEoP and explore the association with sociodemographic and disability-related factors. Design: Cross
Background: White adipose tissue (WAT) dysfunction including an aberrant expression of miRNAs is strongly associated with the risk of developing type 2 diabetes (T2D), with limited evidence linking early changes in the WAT-derived miRNAs and T2D. The present study aims to identify early miRNome changes prognostic for T2D in mice and humans. Methods: Gonadal (g) WAT of diabetes-resistant and diabet
This chapter provides an overview of the different optical sectioning methods that enable performing three dimensional (3D) imaging of possibly complex samples. It discusses their benefits and limitations regarding their penetration depth, their imaging speed, their photo-toxic effect or their complexity. Focusing on fluorescence imaging, the chapter dives into approaches that make it possible to
Plant functional traits are fundamental to ecosystem dynamics and Earth system processes, but their global characterization is limited by available field surveys and trait measurements. Recent expansions in biodiversity data aggregation—including vegetation surveys, citizen science observations, and trait measurements—offer new opportunities to overcome these constraints. Here we demonstrate that
