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Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic
Recent technologies of district heating and cooling (DHC) systems integrate renewable energy sources and connect multiple heat producers and consumers to the same network. The resulting interactions may therefore cause the fluid in the pipe, or the energy carried by the system, to flow in both directions. This article presents a newly developed analytical method for evaluating the hydraulic states
Context: Contemporary patients with primary hyperparathyroidism are diagnosed with milder disease than previously. Clinical and biochemical factors predictors with an impact on fracture incidence and bone mineral density after surgery have not been firmly established. Objective: To investigate predictors of fracture incidence and bone mineral density preoperatively and after surgery for primary hy
IMPORTANCE During the past decade, spinal surgical procedures have been increasingly performed on an ambulatory basis, a change in clinical practice supported only by observational evidence thus far. There have been no randomized clinical trials (RCTs) comparing ambulatory care with inpatient care after any spinal surgery. OBJECTIVE To assess whether ambulatory care is noninferior to overnight hos
Hydrological modelling is essential for effective water resources management, as it represents complex physical processes through mathematical equations to improve our understanding of the water cycle. FLEXG is a glacio-hydrological model that has been successfully applied and found to perform well in glacierized regions. This study seeks to improve the capability of classical FLEXG model for glac
Background: The Prostatype score (P-score) is a prognostic biomarker that integrates a three-gene (IGFBP3, F3, and VGLL3) signature derived from prostate biopsy samples, with key clinical parameters, including prostate-specific antigen (PSA) levels, Gleason grade, and tumor stage at diagnosis. The test has demonstrated superior predictive accuracy for prostate cancer outcomes compared with traditi
In a global retrospective assessment, this study quantifies the potential impacts of croplands on biodiversity using the UNEP-Life Cycle Initiative's recommended method for land use that was proposed by the GLAM consensus working group for Global Guidance for Life Cycle Impact Assessment Indicators and Methods. The findings show the importance of using tools that account for both occupied area and
Given the important role of the land surface for climate, this study aims at (1) to evaluate the quality of the simulation of surface climate by the land-surface component of the EC-Earth3 ESM and (2) to assess the role of the coupling of the land surface with the atmosphere for the simulation of the surface climate in EC-Earth3. It is based on three simulations with different configurations of th
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods:
The objectives were to translate the University of Jyvaskyla Active Aging Scale (UJACAS) to Swedish, to establish semantic equivalence and evaluate psychometric properties for use among persons 55 years and older in Sweden. The UJACAS contains 17 items to be self-assessed regarding goals, abilities, opportunity, and activity. Psychometric properties content validity, data quality including floor a
Background: The application of a bioresorbable calcium sulfate/hydroxyapatite (CaS/HA) ceramic at the interface of fenestrated screws and osteoporotic bone significantly enhances the immediate mechanical anchorage compared with non-augmented controls. However, the anchoring effectiveness of different screw augmentation techniques in spines with varying vertebral bone mineral density (BMD) remains
Det hållbara arbete som idag utförs på olika enheter i staden ser ut att vara beroende av individers engagemang, snarare än deras kunskap kring vilka miljömål som ska uppnås av förvaltningen och vidare den specifika enheten. Osäkerheter bland medarbetarna kring; att de ska arbeta hållbart, vem som ansvarar för det hållbara arbetet, hur de ska arbeta hållbart samt vilka konsekvenser det får att arb
Bygg- och fastighetsbranschen utgör i dagsläget en betydande andel av Sveriges naturresursutvinning samt klimatpåverkan, där påverkan från traditionella stommar av betong och stål länge har dominerat. Klimatintensiva processer såsom cement- och stålproduktion är bidragande faktorer till att branschen är i behov av en hållbar och cirkulär omställning. Återbruk och cirkulärt byggande erbjuder hållbaToday, the construction and real estate industry accounts for a sizable portion of the market´s material consumption and climate impact, with traditional structural materials such as concrete and steel long dominated. Processes such as cement and steel production contribute to the industry´s need for a sustainable transition and circular transition. Reuse and circular construction offer sustainabl
Denna uppsats behandlar tvångsinlösen av minoritetsaktier i onoterade bolag i syfte att klargöra rättsläget genom att analysera gällande rätt. Tvångsinlösen av minoritetsaktier möjliggörs när en majoritetsaktie-ägare äger nio tiondelar av aktierna i ett bolag. Majoritetsaktieägaren kan då lösa in en eller flera minoritetsaktieägares aktier i bolaget. Lösenbeloppet blir ofta föremål för tvist, särThis essay answers a series of questions regarding the process of valuation of shares in unlisted limited companies when subject to a squeeze-out. The purpose of the thesis is to clarify the legal position by analysing the law. A squeeze-out is enabled when a shareholder owns more than nine tenths of the shares in a company. The majority shareholder may then choose to force the minority sharehold
