Filetype
In this study we examined the involvement of the focal adhesion-associated proteins p125FAK and paxillin as substrates for bradykinin (BK)-stimulated tyrosine phosphorylation in Swiss 3T3 cells and the potential role of protein kinase C and Ca2+ in these events. BK (1 UM) stimulated tyrosine phosphorylation of p125FAK and paxillin. In addition, BK also increased the phosphotyrosine content of the
In the recovery phase after a radioactive release incident, it is important to be able to focus decontamination operations on the areas that contribute most to the radiation dose. Monte Carlo simulations were applied to determine the shielding effect of a building against radiation from various directions, also giving information on the dose contributions at various locations inside the building f
The need for frequent retreatment is a disadvantage of using endoscopic laser therapy (ELT) alone for palliative treatment of esophageal carcinoma. In this prospective study, therefore, we investigated the potential and feasibility of combining ELT with a self-expanding metallic stent (Wallstent). Twelve patients received ELT followed by stent placement (stent group) and were compared with 39 pati
Aims: The aim of this study was to test a Child-Centred Health Dialogue model for primary prevention of obesity for 4-year-old children in Child Health Services, for its feasibility and the responsiveness of its outcomes.Methods: A feasibility study was set up with a non-randomised quasi-experimental cluster design comparing usual care with a structured multicomponent child-centred health dialogue
The reduction of public expenditure and investments in health care provisioning calls for new, sustainable models to transform the increasing aging population and dementia-related diseases incidence from global challenges into new opportunities. In this context, Information and Communication Technologies play a vital role, to both promote aging in place and home management of Patients with Dementi
Ecosystem-based adaptation (EbA) to climate change is an approach claimed to deliver social benefits relevant to marginalized groups. Based on a structured literature review, we interrogate such claims, asking whether such approaches may (or may not) contribute to social change and, more specifically, empowerment. We present a review of the predominant meaning and interlinkages of the EbA and empo
Subcortical deafferentation of the hippocampal formation is known to induce profound behavioural deficits. Transplants of fetal septal or brainstem tissue are capable of restoring some aspects of normal physiological and behavioural function in subcortically deafferented (i.e. fimbria-fornix or septal lesioned) rats. Such grafts have been shown to re-establish extensive new afferent inputs to the
The Puchezh-Katunki impact structure, 40–80 km in diameter, located ~400 km northeast of Moscow (Russia), has a poorly constrained age between ~164 and 203 Ma (most commonly quoted as 167 ± 3 Ma). Due to its relatively large size, the Puchezh-Katunki structure has been a prime candidate for discussions on the link between hypervelocity impacts and extinction events. Here, we present new 40Ar/39Ar
At synchrotron light storage rings there is demand for serving both high-brilliance and timing users simultaneously. At many rings this is commonly achieved by operating fill patterns with gaps of sufficient length, but this is not favorable for rings that operate with passive harmonic cavities to damp instabilities and increase Touschek lifetime by lengthening the bunches. For such rings, gaps in
The commissioning of the MAX IV synchrotron radiation facility in Lund marks the dawn of a new generation of storage-ring-based light sources. This new generation delivers one order of magnitude higher performance and allows realization of groundbreaking experiments on a variety of systems and materials at the atomic and molecular levels. This paper reviews the conceptual basis of the MAX IV desig
Focus on customer and market needs has initialized changes in product development work, which involve integration of industrial design and engineering design functions. Interdisciplinary teams are considered a prerequisite in order to achieve collaboration, and a necessity to meet market demands in new products. However, interdisciplinary teams are inherently associated with collaborative shortco
Extracellular vesicles (EVs) are submicron, membrane-enclosed particles that are released from cells in various pathophysiological states. The molecular cargo of these vesicles is considered to reflect the composition of the cell of origin, and the EV proteome is therefore a potential source of biomarkers for various diseases. Our aim was to determine whether EVs isolated from plasma provide addit
Background: The transition towards a more sustainable energy system is urgent for addressing global environmental and social challenges, and will require transformative changes including improved energy efficiency in the built environment. To reach identified efficiency potentials, various policy instruments have been introduced but their effects are often unclear. In this paper, we argue that the
