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This literature review seeks to map the state of research on the effects of digitization on personal financial behavior and management through a bibliometric analysis and a systematic literature review. The findings indicate that current knowledge is primarily based on perspectives of actors in commerce and systems development. More research is needed on how personal financial behavior change in r
Background: Thyroid function has been associated with breast cancer risk, and breast cancer cell growth and proliferation. It is not clear whether thyroid function affects prognosis following breast cancer but, if so, this could have an important clinical impact. The present study analysed prospectively collected measurements of free tri-iodothyronine (T3), free thyroxine (T4), thyroid-stimulating
Objective: The aim of this study was to analyse the impact of maternal BMI at start of pregnancy and maternal weight gain during pregnancy on the risk of various diseases later in life. Methods: In a population-based cohort from southern Sweden, women with at least one delivery registered in the Swedish Medical Birth Register ten or more years before answering a health questionnaire were identifie
Context: Somatostatin inhibits a range of hormones, including GH, insulin, and glucagon, but little is known about its role in the development of cardiometabolic disease. Objective: The objective of the study was to investigate whether fasting plasma concentration of N-terminal prosomatostatin (NT-proSST) is associated with the development of diabetes, coronary artery disease (CAD), and mortality.
Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare report
Human pluripotent stem cells provide new choices for sources of A9-type dopaminergic (DA) neurons in clinical trials of neural transplantation for patients with Parkinson's disease (PD). For example, "self" and HLA-matched A9 DA neurons may improve the patient-to-patient variability observed in previous clinical trials using fetal DA neurons and obviate the need for long-term immunosuppression in
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used -1/4155,063 samples for independent replication. We identified 30 new bloo
Background: To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA). Methods: Individuals who developed GCA after inclusion in two population-based health surveys were identified through linkage to the local and the national patient registers. In addition, other patients diagnos
Objective: Preoperative pain and function is viewed as an important predictor of total knee arthroplasty (TKA) outcomes. We examined whether variations in pain and function outcomes existed at 12 months between two centres in Sweden and Australia, and whether this was explained by variations in patient presentation for TKA. Methods: This was a retrospective analysis of prospectively collected data
Thanks to its ability to form a lattice of self-ordered nanosized pores, nanoporous anodic aluminum oxide (NP-AAO) is a promising material with diverse applications, for example, as membrane for the controlled deposition of catalysts. NP-AAO is obtained by the anodization of an aluminum substrate under specific pH and voltage conditions. However, the growth mechanism of the oxide is still under de
Passivity refers to spontaneous formation of a passive film on the surface of metals. High stability of the passive film on advanced alloys relies on the repassivation ability of the alloys in corrosive environments. Two Ni-base superalloys (Ni-22Cr-9Mo-5Fe-2Nb and Ni-18Cr-3Mo-20Fe-5Nb) are studied to elucidate the mechanism of repassivation through a combination of multimodal in-situ synchrotron
Background: Focal cortical dysplasia (FCD) is a developmental cortical malformation and a leading cause of drug-resistant epilepsy that often requires epilepsy surgery. Some FCD patients experience acute postoperative seizures (APOS) following surgery. The relationship between APOS and long-term prognosis for patients with FCD is at present unclear. The primary aim of this study was to analyze the
Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet and Cancer Study (a population-based prospective study consisting of 17,035 women)
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and
Förbudet mot köp av sexuella tjänster har varit i kraft i 16 år. Den debatt som åtföljt lagstiftningsarbetet kan dock sägas ha pågått under närmare 40 år. Det är en debatt med starka ideologiska förtecken och det är tydligt att prostitution är en fråga som inte lämnar någon oberörd. Uppsatsens syfte är utreda vilka ideologiska värderingar och skyddsintressen som återfinns i lagstiftarens syn på pThe Swedish prohibition of the purchase of a sexual service has been in effect for 16 years. The debate accompanying the legislation process has, however, been going on for almost 40 years. It is a debate with a strong ideological nature and it is clear that prostitution is a phenomenon that leaves no one unaffected. The aim of this essay is to investigate which ideological values have affected th
Enligt svensk rätt ska utländska äktenskap erkännas om de är giltiga enligt lagen i det land de ingåtts. Undantaget till detta är om äktenskapet går emot svensk ordre public. Huruvida så är fallet för polygami är fortfarande osäkert. Det här arbetet kommer inte beröra huruvida Sverige bör ha en begränsning på antal äktenskap eller inte, utan fokus ligger på den svenska hanteringen av utländska polAccording to Swedish law a foreign marriage is recognized if it is valid under the law of the state where it was entered into. The exception to this is if such a marriage is void as a matter of public policy. Whether or not that applies to polygamy is still uncertain. This thesis will not touch upon whether or not Sweden should have a restriction on the number of parties in a marriage; instead it
Background: Following the results of the MANDARA trial, this real-life study aimed at comparing the effectiveness and safety profile of mepolizumab versus benralizumab in a European EGPA cohort. Methods: We conducted a retrospective observational comparative study including EGPA patients, who received mepolizumab or benralizumab at the asthma dose. Patients were matched 1:1 by sex, age, BVAS and o
Ageing in the human brain is a major risk factor for most neurodegenerative diseases. Yet the cell-type-specific molecular changes that contribute to this risk remain poorly understood. This thesis investigates cell-type-specific changes across multiple levels of molecular regulation and their roles in physiological and pathophysiological brain ageing. Using single-nucleus RNA sequencing of postmo
Background: – Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children, and results in kidney failure in up to one third of cases. There is very limited knowledge on kidney transplantation in childhood-onset AAV. We assessed kidney transplantation outcomes and prognostic factors in a multicentre cohort of patients with childhood-onset AAV.Methods: – Patients diag
