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Metal Halide Perovskite/Chalcohalide Heterojunctions for the Photoinduced Oxidative Coupling of p-Substituted Thiophenols

The introduction of a semiconductor–semiconductor junction is an effective strategy to enhance the photocatalytic performance of perovskite nanocrystal-based systems. Herein, we optimized the synthesis of CsPbX3/Pb4S3Y2 (X, Y = Cl, Br, I) perovskite/chalcohalide heterostructures, whose band alignment can be tuned by the halide composition. As a proof-of-concept, we evaluated the photooxidative cou

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key ques

A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort

PURPOSE: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovar

Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations

The risk of pancreatic cancer (PC) is increased in melanoma-prone families but the causal relationship between germline CDKN2A mutations and PC risk is uncertain, suggesting the existence of non-CDKN2A factors. One genetic possibility involves patients having mutations in multiple high-risk PC-related genes; however, no systematic examination has yet been conducted. We used next-generation sequenc

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö diet and cancer cohort

Background: By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk. Methods: We included 24,799 participants (62 % women, age 4

Screening for Prostate Cancer Starting at Age 50-54 Years. A Population-based Cohort Study

Background: Current prostate cancer screening guidelines conflict with respect to the age at which to initiate screening. Objective: To evaluate the effect of prostate-specific antigen (PSA) screening versus zero screening, starting at age 50-54 yr, on prostate cancer mortality. Design, setting, and participants: This is a population-based cohort study comparing 3479 men aged 50 yr through 54 yr r

Treatment with a GnRH receptor agonist, but not the GnRH receptor antagonist degarelix, induces atherosclerotic plaque instability in ApoE-/- mice

Androgen-deprivation therapy (ADT) for prostate cancer has been associated with increased risk for development of cardiovascular events and recent pooled analyses of randomized intervention trials suggest that this primarily is the case for patients with pre-existing cardiovascular disease treated with gonadotropin-releasing hormone receptor (GnRH-R) agonists. In the present study we investigated

Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.

Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008

Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide.

Having performed analytical validation studies, we are now assessing the clinical utility of the upgraded automated Bone Scan Index (BSI) in metastatic castration-resistant prostate cancer (mCRPC). In the present study, we retrospectively evaluated the discriminatory strength of the automated BSI in predicting overall survival (OS) in mCRPC patients being treated with enzalutamide.

Self tuning cylinder pressure based heat release computation

The paper describes a novel method for self tuning cylinder pressure based heat release computation that is suitable for online usage in e.g. combustion phasing control applications. The method estimates the polytropic exponents and cylinder pressure offsets immediately preceding and succeeding the combustion event respectively using a fast nonlinear least squares method. The polytropic exponent a

Åka hem? – Den individuella utlänningskontrollen och rörlighetsdirektivets genomförande i svensk rätt

I folkrättsligt hänseende är en stat endast skyldig att låta de egna medborgarna uppehålla sig på dess territorium. Ur ett EU-rättsligt perspektiv är dock varje medlemsstat förpliktad att tillämpa de regler som avser främja fri rörlighet för personer inom unionen. Dessa återfinns i EU:s primärrättsliga stadganden men konkretiseras genom sekundärrättsliga bestämmelser, framförallt genom direktiv 20With regard to international law, a state is only required to allow its citizens to reside within its own territory. However, from an EU law perspective, each Member State is obliged to apply regulations which intend to facilitate the free movement of persons within the EU. This is expressly laid down in the EU treaties, but must be viewed within the context of secondary law, in particular, the Ci

Den historiska utvecklingen av internationell adoption på Sri Lanka - I linje med barnets bästa?

Under 1980-talet var Sri Lanka ett av de länder som flest barn adopterades internationellt ifrån, med 6815 registrerade adoptioner. Antalet adoptioner har sen dess fallit kraftigt. Under 2010-talet registrerades bara 259 stycken – detta trots den stora mängd barn som fortsatt växer upp på institutioner i landet. Hur kommer detta skifte sig och vad har det inneburit för barns rättigheter och tolkni

A comparison of the Basel III capital requirement models for financial institutions

The purpose of this report is to implement and compare the two Basel III standard methods on how to calculate the capital requirement for finan- cial institutions, related to counterparty credit risk. The models being the Standardized Approach for Counterparty Credit Risk (SA-CCR) and the Internal Model Method (IMM). The SA-CCR model is a simpler and more standardized model with prescribed methods