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Low expression of SHP-2 is associated with less favorable prostate cancer outcomes.

ABSTACT: Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor speci

Adrenomedullin is a marker of carotid plaques and intima-media thickness as well as brachial pulse pressure.

Adrenomodulin (ADM) is a peptide hormone secreted in response to cellular strain such as ischemia and is believed to have a beneficial effect on the cardiovascular system. However, the epidemiological relationships between ADM and measurements of haemodynamics, arteriosclerosis and atherosclerosis are not well established. The aim of this study was to investigate the association between the mid-re

Studying Norms and Social Change in a Digital Age: Identifying and Understanding a Multidimensional Gap Problem

The fact that the debate concerning copyright in a digital society has been both intense and filled with polemic conflicts ever since the late 1990s makes it clear that it is a most complicated issue to solve, or even grasp. Basically, both the legal and societal discussion and development are explicitly dependent on a greater understanding of the on-going processes surrounding copyright. This pre

Avoiding procrastination and the planning fallacy : Implementing study-plans as a strategy to increase student achievement

Within a course in academic writing, first-term students of English currently construct individualized study-plans detailing both what they should do during the term and when they should do it. Students calculate the average workload for all their courses, and include in their study-plans all the hours they should spend both in and outside the classroom on each course, totalling in 40-hour working

Reconciliation Narratives of Survivors from War in Bosnia and Herzegovina

The aim of this article was to analyze the retold experiences of 27 survivors from the 1990s war in Bosnia and Herzegovina. I have examined verbal markers of reconciliation and implacability and I have analyzed described terms for reconciliation that are being actualized in the narratives. In the narratives of those interviewed, implacability is the prominent them, but the possibility of reconcili

Servicemötets praktik : på en tingsrätt, ett äldreboende och ett hotell

The practice of service encounters in a district court, a home for the elderly, and a hotel Service management research places the service encounter in a central position. It is highlighted as a key event that involves the simultaneous production, consumption, and marketing of the services produced by the operation. However, in this research there is a tendency to discuss the service encounter in

Kränkningar, trakasserier och hot på nätet. Delrapport till Ungdomsstyrelsen med fokus på kvantitativ kartläggning.

Den här delrapporten utgår från empirisk data som samlats in inom ramen för det rättssociologiska forskningsprojektet Kränkningar i en digital kontext som finansieras av Brottsofferfonden. Bearbetningen har genomförts av Måns Svensson (projektansvarig) och Karl Dahlstrand, båda verksamma vid Rättssociologiska institutionen vid Lunds universitet. Rapporten har sammanställts på uppdrag av Ungdomssty

Footwear for cold weather conditions

In cold climates all user requirements for footwear (insulation, waterproof, vapour permeability, drying etc.) can’t be met easily due to their conflicting nature. Defining user conditions is important. Cold may be roughly divided into the three ranges (>+5; +5 to 10; < 10 °C). The choice of proper footwear may be based on this approach. It also reduces some of the conflicting user requirements. U

Value Taxonomy

The paper presents main conceptual distinctions underlying much of modern philosophical thinking about value. The introductory Section 1 is followed in Section 2 by an outline of the contrast between non-relational value (impersonal good, or good, period) and relational value (good for someone, or—more generally—good for some entity). In Section 3, the focus is on the distinction between final and

Instruments for a European Extremely Large Telescope: the challenges of designing instruments for 30- to 100-m telescopes

Designs for Extremely Large Telescopes (ELTs) are quite well advanced,but the requirements of instruments have had limited impact. Sinceprovision of a suitable environment for instruments is a critical aspectof all telescopes, we outline some well-known and some less-appreciatedchallenges of designing instruments for ELTs. A wide-field spectrometer(WFSPEC) with ~10 arcmin field-of-view, probably w