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We have previously proposed and evaluated acoustophoresis for the enrichment of circulating tumor cells (CTC) and clusters thereof from the blood of patients with prostate cancer [1]. In that protocol, the cells were fixed and preserved in paraformaldehyde before processing and were thus non-viable. To enable future enrichment of also viable CTCs from patients, we have in this study investigated t
We recently introduced the concept of thermoacoustic streaming in microchannels wherein a thermal field is generated inside an acoustic cavity. The result is a fast and controllable streaming for which the thermal energy is provided either by an LED light source [1], or a laser [2]. While in previous works we have measured this effect at steady state, we now present measurements of the build-up an
By combining acoustic fields and liquid flows in microchannels we develop tools to chart and separatebiological particles based on their bio-mechanical properties. I will present an overview of three ongoingprojects where acoustic forces are utilized to separate blood cells.We studied the packing behavior of whole blood in a sound field. We discovered that cells self-organizesuch that red blood cells
Direct thermal-to-electric energy converters typically operate in the linear regime, where the ratio of actual maximum power relative to the ideal maximum power, the so-called fill factor (FF), is 0.25. Here, we show, based on fundamental symmetry considerations, that the leading order nonlinear terms that can increase the FF require devices with broken spatial symmetry. Studying nonlinear, thermo
BACKGROUND: Perfluoroalkyl substances (PFAS) have been associated with impaired antibody levels after childhood vaccinations and immunosuppressive effects in animals. However, the in vivo effects of PFAS on antigen specific human T cell responses have not been investigated in adults. In Ronneby, Sweden, the drinking water of one of the water works was previously highly contaminated with primarily
Extracellular plaques in Alzheimer’s disease contain Aβ peptides and ganglioside lipids such as GM1. Aβ monomers self-assemble into beta-sheet-rich fibrils when their concentration exceeds solubility, while GM1 monomers form spherical micelles above their critical concentration. This study examines the self-assembly of Aβ in the first two papers and its co-assembly with GM1 in the last two. In Pap
The band offsets of semiconductor heterojunctions are critical parameters for the design of electronic and optoelectronic devices. In this work, we report the fabrication of a Co3O4/3C-SiC p-n heterojunction and the determination of the conduction band and valence band offsets at the Co3O4/3C-SiC heterojunction. Our results reveal that the Co3O4/3C-SiC p-n heterojunction exhibits a type-II band al
Newts have large genomes harboring many repeat elements. How these elements shape the genome and relate to newts' unique regeneration ability remains unknown. We present here the chromosome-scale assembly of the 20.3 Gb genome of the Iberian ribbed newt, Pleurodeles waltl, with a hitherto unprecedented contiguity and completeness among giant genomes. Utilizing this assembly, we demonstrate conserv
The onset and development of Alzheimer’s disease is linked to the accumulation of pathological aggregates formed from the normally monomeric amyloid-β peptide within the central nervous system. These Aβ aggregates are increasingly successfully targeted with clinical therapies at later stages of the disease, but the fundamental molecular steps in early stage disease that trigger the initial nucleat
In recent years, studies of surfaces at more realistic conditions has advanced significantly, leading to an increased understanding of surface dynamics under reaction conditions. The development has mainly been due to the development of new experimental techniques or new experimental approaches. Techniques such as High Pressure Scanning Tunneling/Force Microscopy, Ambient Pressure x-ray Photo emis
Nowadays organisms encounter not only natural challenges from predators but also significant anthropogenic stressors, such as insecticides, which can profoundly disrupt their normal growth and behavior. However, the knowledge on their potential interactions remains largely unknown, particularly regarding how insecticides may affect predator-prey interactions and prey responses across multiple gene
Semiconductor nanowires can enhance the signal of fluorescent molecules, thus significantly improving the limits of fluorescence detection in optical biosensing. In this work, we explore how the sensitivity can further be enhanced through "digital"detection of adequately spaced vertically aligned nanowires, employing single-emitter localization methods, and bright-field microscopy. Additionally, w
AIMS: Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features.METHODS AND RESULTS: The cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited
Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and prevalence of autoimmunity. Intrinsic biological sex differences arise from varying contributions of chromosomal sex, and sex hormone sensing and downstream signa
Mantle plumes are subject of a great discussion within the field of Geology. Do they really exist, and in that case, from where do they originate? The scope of this Bachelor thesis is to discuss the characteristics of mantle plumes and the arguments in favor of and against their proposed existence. The mantle plume hypothesis was first presented in 1971 by Jason Morgan, suggesting diapirs of hot r
Förbudet mot köp av sexuella tjänster har varit i kraft i 16 år. Den debatt som åtföljt lagstiftningsarbetet kan dock sägas ha pågått under närmare 40 år. Det är en debatt med starka ideologiska förtecken och det är tydligt att prostitution är en fråga som inte lämnar någon oberörd. Uppsatsens syfte är utreda vilka ideologiska värderingar och skyddsintressen som återfinns i lagstiftarens syn på pThe Swedish prohibition of the purchase of a sexual service has been in effect for 16 years. The debate accompanying the legislation process has, however, been going on for almost 40 years. It is a debate with a strong ideological nature and it is clear that prostitution is a phenomenon that leaves no one unaffected. The aim of this essay is to investigate which ideological values have affected th
Enligt svensk rätt ska utländska äktenskap erkännas om de är giltiga enligt lagen i det land de ingåtts. Undantaget till detta är om äktenskapet går emot svensk ordre public. Huruvida så är fallet för polygami är fortfarande osäkert. Det här arbetet kommer inte beröra huruvida Sverige bör ha en begränsning på antal äktenskap eller inte, utan fokus ligger på den svenska hanteringen av utländska polAccording to Swedish law a foreign marriage is recognized if it is valid under the law of the state where it was entered into. The exception to this is if such a marriage is void as a matter of public policy. Whether or not that applies to polygamy is still uncertain. This thesis will not touch upon whether or not Sweden should have a restriction on the number of parties in a marriage; instead it
Att ha förtalat någon är att ha begått ett brott. Men processrätten kring förtalsbrottet skiljer sig från vanliga brott. Om brottet varit tillräckligt kvalificerat tar åklagare över åtalet som ett allmänt åtal men om det inte nått upp till denna gräns har det ålegat den enskilde att väcka åtal. Det är främst den typen av brott som inte nått upp till gränsen för allmänt åtal som denna uppsats tagitTo have slandered someone is to have committed a crime. But the procedure surrounding the crime of slander differs from regular crimes. If the crime is considered qualifying enough a prosecutor will take over the case as general prosecution but if the crime hasn’t lived up to that level it’s up to the individual to arouse individual prosecution. It’s mainly the type of offense that doesn’t qualify
Denna uppsats undersöker hur systemet för ersättning av rättegångskostnader i förvaltningsprocessen förhåller sig till rätten till en rättvis rättegång. Denna uppsats undersöker också vilka möjligheter som finns för att få ersättning för rättegångskostnader i förvaltningsprocessen genom en separat skadeståndsta-lan i allmän domstol. För att svara på frågeställningarna tillämpas rättsdogmatisk metoThis thesis examines the system for reimbursing legal costs in the administra-tive law proceedings and how it relates to the right to a fair trial. It also inves-tigates the possibilities for obtaining reimbursement of legal costs in adminis-trative proceedings through a separate damages claim in a general court. To address the research questions, a legal dogmatic method is applied, with a signif
