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In this work, we present a ridged, microfabricated, force sensor that can be used to investigate mechanical interactions between cells exhibiting contact guidance and the underlying cell culture substrate, and a proof-of-function evaluation of the force sensor performance. The substrates contain arrays of vertical pillars between solid ridges that were microfabricated in silicon wafers using photo

Reactions of cis-[PtCl(NH3)(CyNH2)(OH2)](+) (Cy = cyclohexyl) with thione-containing single-stranded oligonucleotides d(T8XT8) and d(XT16) (X = I-s6 or U-s4) and the mononucleotides 4-thiouridine ((UMP)-U-s4) and 6-mercaptoinosine ((IMP)-I-s6) have been studied in aqueous solution at pH 4.1. The reaction kinetics was followed using HPLC methodology as a function of ionic strength in the interval 5

This article by the ESPGHAN Committee on Nutrition summarizes available information on the effects of adding prebiotic oligosaccharides to infant and follow-on formulae. Currently there are only limited studies evaluating prebiotic substances in dietetic products for infants. Although administration of prebiotic oligosaccharides has the potential to increase the total number of bifidobacteria in f

A widely used estimate claims that one per thousand individuals is deaf, but few recent studies exist on the actual prevalence. The aim of this study was to investigate the prevalence of deaf people, defined as deaf individuals who use sign language as their main mode of communication, in the county of Scania, Sweden. To achieve high validity, data were collected from a large variety of sources in

The aim of this study was to optimize the use of BMD measurements in case finding strategies. The use of clinical risk factors with and without BMD was explored in a random sample of the Sheffield female population greater than or equal to75 years of age. The use of clinical risk factors alone could identify women well above or well below a threshold of fracture risk. BMD assessment can be confine

We show that the boundary conditions entering in the definition of the self-adjoint operator Delta(A,B) describing the Laplacian plus afinite number of point interactions are local if and only if the corresponding wave equation phi = Delta(A,B)phi has finite speed of propagation.

This paper presents an analysis of the Ziegler-Nichols frequency response method for tuning PI controllers, showing that this method has severe limitations. The limitations can be overcome by a simple modification for processes where the time delay is not too short. By a major modification it is possible to obtain new tuning rules that also cover processes that are lag dominated.

Thoracic cirripedes are sessile crustaceans that use six pairs of thoracic appendages (the cirri) to catch and handle food. We used scanning electron microscopy to examine the cirri, which include one to three pairs of maxillipeds in six species of thoracican barnacles, in search of correlations between cirral setation and feeding mode. The species studied comprise both pedunculate and sessile for

Deuteron-gold (d+Au) collisions at the Relativistic Heavy Ion Collider provide ideal platforms for testing QCD theories in dense nuclear matter at high energy. In particular, models suggesting strong saturation effects for partons carrying small nucleon momentum fraction (x) predict modifications to jet production at forward rapidity (deuteron-going direction) in d+Au collisions. We report on two-

BACKGROUND. With a substantial rise in the incidence of skin cancer, skin surgery has become an increasingly large part of dermatology. Skin surgery is best performed by dermatologists. This demands effective training in dermatologic surgery, including flap surgery. OBJECTIVE. To find a modern alternative to traditional training on pig's feet skin in teaching flap surgery to residents in dermatolo

A shoreline to deep basin correlation chart for the middle Silurian coupled extinction-stable isotopic event is presented. The chart is a first attempt to synthesise new stratigraphic, faunal and stable isotopic data, as well as diversity changes among organic-walled microplankton (acritarchs), from the Grotlingbo-1 and Hunninge-1 cores on Gotland (Sweden), along with previously published data fro

Cutting tool spontaneous failure such as, edge fracture and chipping are common phenomena in the metal cutting process, especially when difficult workpiece materials which have poor cutibility are met in the machining process. The tool failures are often caused by high mechanical and thermal stresses acting in it. Monitoring stresses acting in a cutting edge during machining process can provide mo

Background: While the association between increased maternal age and congenital disorders has long been recognized, the offspring of older fathers are also at increased risk of congenital disorders related to DNA errors during spermatogenesis. Recent studies have drawn attention to an association between increased paternal age and increased risk of schizophrenia. The aim of the current study was t

The goal oriented framework (GOF) for indicators has been developed as part of a comprehensive research project developing computerised tools for integrated assessment of the effects of new policies or technologies on agricultural systems (SEAMLESS-IF). The ambition has therefore been to create an indicator framework where the environmental, economic and social dimensions of sustainable developmen

A mathematical model for through drying of paper at constant pressure drop was developed. The model is based on physical properties; hence, basis weight, pressure drop, drying air temperature, pore size distribution, initial gas fraction, and tortuosity are important input parameters to the model. The model was solved for different combinations of the variables basis weight, drying air temperature

Membrane electrode assemblies (MEAs) with a sulfonated polysulfone (sPSU) as the proton-conducting phase were fuel cell evaluated at varying temperatures in over-humidified conditions. The sPSU was prepared by a direct polycondensation involving a commercially available sulfonated naphthalene diol monomer. The gas diffusion electrodes (GDEs) and MEAs were successfully fabricated and a thorough mor

Protein H, a molecule expressed at the surface of some strains of Streptococcus pyogenes, has affinity for the constant (IgGFc) region of immunoglobulin (Ig) G. In absorption experiments with human plasma, protein H-sepharose could absorb not only IgG but also albumin from plasma. The affinity constant for the reaction between albumin and protein H was 7.8 x 10(9) M-1, which is higher than the aff

A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoreti