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To compare the internal computer-based scoring with human-based video scoring of cataract modules in the Eyesi virtual reality intraocular surgical simulator, a comparative case series was conducted at the Department of Clinical Sciences - Ophthalmology, Lund University, Skåne University Hospital, Malmö, Sweden.
Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic acids has recently been implicated in the development of cancer and other pathological conditions; however, the mechanism of EV uptake and how this may be targeted remain as important questions. Here, we provide evidence that heparan sulfate (HS) proteoglycans (PGs; HSPGs) function as internalizing recepto
In Safeguards work under the Non-Proliferation Treaty, the isotopic analysis of uranium and plutonium micro particles has strengthened the means for detecting undeclared nuclear activities. In order to assure accuracy and precision in the analytical methodologies used, the instrumental techniques need to be calibrated. The objective of this study was to produce and characterize particles consistin
To assess older age as a prognostic factor in patients resuscitated from out-of-hospital-cardiac arrest (OHCA) and the interaction between age and level of target temperature management.
Pain is a key unmet need and a major aspect of non-motor symptoms of Parkinson's disease (PD). No specific validated scales exist to identify and grade the various types of pain in PD. We report an international, cross-sectional, open, multicenter, one-point-in-time evaluation with retest study of the first PD-specific pain scale, the King's PD Pain Scale. Its seven domains include 14 items, each
Informal (dementia) care has economic consequences throughout the health care system. Whilst the health and wellbeing of the care recipient might improve, the health of the caregiver might also change, typically for the worse. Therefore, this analysis aims to examine the association between caregiving intensity and caregivers' health and health care utilization.
Airway hyperreactivity (AHR) is a major feature of asthmatic and inflammatory airways. Cigarette smoke exposure, and bacterial and viral infections are well-known environmental risk factors for AHR, but knowledge about the underlying molecular mechanisms on how these risk factors lead to the development of AHR is limited. Activation of intracellular mitogen-activated protein kinase (MAPK)/nuclear
The effects of the physical-spatial-technical environment on aging well have been overlooked both conceptually and empirically. In the spirit of M. Powell Lawton's seminal work on aging and environment, this article attempts to rectify this situation by suggesting a new model of how older people interact with their environment. Goals of the paper include (a) integration of the essential elements o
Engaging old users in the exploration of future product concepts can be challenging. It is of great value to find ways to actively involve them in the design of novel technologies intended for them, particularly when they have no prior experience of the technology in question. One obstacle in this process is that many old people do not identify themselves as being old or they think that it (the te
Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cogn
The aim of this study was to increase patients' adherence to the treatment of hypertension through the consultation training of nurses. Thirty-three nurses were included in the study. In the intervention group (IG), 19 nurses took part in a 3-day residential training course on the Stages of Change model, Motivational Interviewing and guidelines for cardiovascular prevention, and recruited 153 pati
Residential energy consumption remains a significant driver of CO2 emissions in European buildings, demanding urgent action in the face of the climate crisis. While prevailing efforts have predominantly concentrated on enhancing energy efficiency and integrating renewable sources, addressing the climate urgency and resource constraints necessitates a paradigm shift towards sufficiency principles.
The building sector is the largest consumer of energy in industrial countries. Saving energy in new buildings or building renovations can thus lead to significant global environmental impacts. In this endeavor, building information modeling (BIM) and building energy modeling (BEM) are two important tools to make the transition to net-zero energy buildings (NZEB). So far, little attention has been
Background: The application of Pulsed Electric Field (PEF) to food may result in reversible or irreversible electroporation of cell membranes, depending on whether cell homeostasis is restored after resealing. Restoration of homeostasis upon reversible electroporation implies the recovery of the pre-pulse transmembrane potential and the restoration of cell metabolic functions. Enhanced membrane pe
In nuclear medicine, radiopharmaceuticals can be administered for both diagnostic and therapeutic purposes. In recent years, there has been an increasing interest in theragnostics, a strategy that combines both diagnosis and therapy. This can be achieved by using similar radiopharmaceuticals for imaging and radionuclide therapy, which enables highly personalised disease management. One theragnosti
Value creation is at the core of business model (BM) research, but the link between BM and value creation remains unclear. In this work, empirical data on BM transformation towards sustainable value creation in the agri-food sector, were obtained through case studies. Factors in BM transformation were identified, transformations in different BM segments were analysed and sustainable value created
The development of sensitive, convenient, and cost-effective methods for detecting disease biomarkers is very important for meeting the growing demand for early clinical diagnosis. Additionally, the detection of disease biomarkers at ultralow concentrations is very important for disease prevention and treatment and posttreatment rehabilitation. However, current ultrasensitive detection strategies
Background: Malnutrition, sedentary lifestyle, cognitive dysfunction and poor psychological well-being are often reported in patients on haemodialysis (HD). Aims: We aimed to explore needs, barriers and facilitators—as perceived by patients, their carers, and healthcare professionals (HCPs) for increasing the adherence to the diet, to physical activity and cognition and psychological well-being. M
