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The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field. These tau PET tracers bind tau neurofibrillary tangles, a key neuropathological characteristic of AD that is tightly linked to synaptic loss, brain atrophy, and cognitive decline. It is notable that these tau PET tracers show low uptake in most non-A

The study of a turbulent premixed flame often involves analysing quantities conditioned to different iso-surfaces of a reactive scalar field. Under the influence of turbulence, such a surface is deformed and translated. To track the surface motion, the displacement speed of the scalar field respective to the local flow velocity is widely used and this quantity is currently receiving growing attent

(KxNa1-x)NbO3 (KNN) and its solid solutions are considered as potential alternatives to traditional Pb-based piezoelectric materials. Recent investigations indicated that the local structure in KNN is much more complex than its long-range average structure. Here, we have undertaken a systematic investigation of the temperature-dependent evolution of local and average structures of KNN5 [(KxNa1-x)N

Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multi

Objective To compare the performance of the bias-adjusted meta-analysis to the conventional meta-analysis assessing seasonal influenza vaccine effectiveness among community-dwelling elderly aged 60 years and older. Study Design and Setting Systematic literature search revealed 14 cohort studies that met inclusion and exclusion criteria. Laboratory-confirmed influenza, influenza-like illness, hos

At present, the prevalence of electric vehicles is increasing continuously. In particular, there are promising applications for commercial vehicles transfering from conventional to full electric, due to lower operating costs and stricter emission regulations. Thus, cost analysis from the fleet perspective becomes important. The study of cost competitiveness of different drivetrain designs is neces

Over the past couple of decades, increased interdependencies between and institutional defragmentation of, our Critical Infrastructures (CIs) have created a setting were traditional risk management might no longer suffice. In particular, analysis and management of risks have evolved from being a predominantly intra-organisational task towards a process that also requires inter-organisational coord

Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350

The focus of this study was the empirical modelling of the high-speed bearings life and failure modes of a through-flow universal motor. An approach was used facilitating predictions of the life through-range of various conditions. The model estimates bearing life for the survival probability of 50% – L50. It influences parameters such as bearing temperature, speed factor, equivalent load, grease

Purpose: Monte Carlo (MC) modelling techniques can assess the quantitative accuracy of both planar and SPECT Nuclear Medicine images. It is essential to validate the MC code's capabilities in modelling a specific clinical gamma camera, for radionuclides of interest, before its use as a clinical image simulator. This study aimed to determine if the SIMIND MC code accurately simulates emission image

Our aesthetic response to the Universe, and the complexity of concepts through which we understand it, are inherently bound together in how we meaningfully interpret its nature. Over millennia the abstracted and intangible concepts of science have been developed and communicated through a rich array of representations across a variety of modes. The interpretation of such representations is a compl

The various problems associated with co-authorship of research articles have attracted much attention in recent years. We believe that this (hopefully) growing awareness is a very welcome development. However, we will argue that the particular and increasing importance of authorship and the harmful implications of current practices of research authorship for junior researchers have not been emphas

While an extensive part of the conflict transformation literature stresses the importance of transforming the identities of conflict parties through recognition, it fails to recognise the propensity of such transformations to generate ontological insecurity and dissonance, and consequently a possible backlash towards antagonistic identities. Drawing on agonistic thought, we develop a conception of

Whether and how long-term energy and climate targets can be reached depend on a range of interlinked factors: technology, economy, environment, policy, and society at large. Integrated assessment models of climate change or energy-system models have limited representations of societal transformations, such as behavior of various actors, transformation dynamics in time, and heterogeneity across and

The European Commission describes a Circular Economy (CE) as an economy “where the value of products,materials and resources is maintained in the economy for as long as possible, and the generation of waste minimised.”But what is value in this context and how should CE policies consider value? Extended producer responsibility(EPR) policies are an important part of an EU CE Action Plan. However, th

The target of zero emissions sets a new standard for industry and industrial policy. Industrial policy in the twenty-first century must aim to achieve zero emissions in the energy and emissions intensive industries. Sectors such as steel, cement, and chemicals have so far largely been sheltered from the effects of climate policy. A major shift is needed, from contemporary industrial policy that ma