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We report on the characterization of the new I1011 beamline at the MAX-II storage ring, in the MAX-lab synchrotron radiation laboratory and give examples of first results. This beamline is using an Elliptically Polarizing Undulator source, producing soft x-rays of a variable polarization state. It delivers high flux and high brightness circularly polarized x-rays in the energy range 0.2 to 1.7 keV
We sought to assess the impact of amino-acid (18)F-fluoro-ethyl-tyrosine (FET) positron emission tomography (PET) on the volumetric target definition for radiation therapy of high-grade glioma versus the current standard using MRI alone. Specifically, we investigated the influence of tumor grade, MR-defined tumor volume, and the extent of surgical resection on PET positivity.
Aromatic side chains are prevalent in protein binding sites, perform functional roles in enzymatic catalysis, and form an integral part of the hydrophobic core of proteins. Thus, it is of great interest to probe the conformational dynamics of aromatic side chains and its response to biologically relevant events. Indeed, measurements of (13)C relaxation rates in aromatic moieties have a long histor
A thermoelastic–plastic body consisting of two phases, a solid and a fluid, each comprising two constituents is considered where one constituent in one phase is allowed to exchange mass with another constituent (of the same substance) in the other phase. A large strain setting is adopted and the formulation applies to general anisotropy and the existence of residual stresses. Generalized forms of
Existing methods of primary stroke prevention are not sufficiently effective. Based on the recently developed Stroke Riskometer app, a new mass-elevated risk stroke/cardiovascular disease prevention' approach as an addition to the currently adopted absolute risk stroke/cardiovascular disease prevention approach is being advocated. We believe this approach is far more appealing to the individuals c
In many countries, practice-oriented programs have been recast as university programs, fueling debate on the purpose of higher education. We highlight two ways of talking about the challenges for higher education we think are already familiar to readers. We label them ‘political-worry discourse’ and ‘academic-worry discourse’. We argue for a third position that gives due recognition to the turn in
Solubility phenomena in supercritical carbon dioxide (SC-CO2) mixtures have been studied in situ using Raman spectroscopy. A Raman spectroscopy instrumentation has been linked to a high-pressure optical cell. The set-up was tested in the system SC-CO2/alkyl ketene dimer (AKD) under pressures up to 300 bars and temperatures up to 80 degrees C. As a proof of concept, the possibility to study solubil
Day centres for people with psychiatric disabilities need to be evaluated for effectiveness in order to provide the best possible support. This study aimed at investigating the effectiveness of a tailor-made intervention to improve day centre services for people with psychiatric disabilities.
Positron emission tomography (PET) with (18)F-FDG is a valuable tool for staging, planning treatment, and evaluating the treatment response for many different types of tumours. The correct volume estimation is of utmost importance in these situations. To date, the most common types of phantoms used in volume quantification in PET utilize fillable, hollow spheres placed in a circular or elliptical
This Letter presents a search for magnetic monopoles with the ATLAS detector at the CERN Large Hadron Collider using an integrated luminosity of 2.0 fb(-1) of pp collisions recorded at a center-of-mass energy root s = 7 TeV. No event is found in the signal region, leading to an upper limit on the production cross section at 95% confidence level of 1.6/epsilon fb for Dirac magnetic monopoles with t
Waste electrical and electronic equipment (WEEE) sheds light on the dimmer side of production and consumption patterns in modern societies. The rapid increase in its quantity and complexity contribute to the challenges it poses to solid waste management systems. Several members of the Organisation for Economic Co-operation and Development (OECD) have relied on the principle of extended producer re
The aim of this study was to test the diagnostic value of cerebrospinal fluid (CSF) beta-amyloid (Aβ1-42), phosphorylated tau, and total tau (tau) to discriminate Alzheimer's disease (AD) dementia from other forms of dementia.
We present a new software framework for Markov chain Monte Carlo sampling for simulation, prediction, and inference of protein structure. The software package contains implementations of recent advances in Monte Carlo methodology, such as efficient local updates and sampling from probabilistic models of local protein structure. These models form a probabilistic alternative to the widely used fragm
This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.RESEARCH DESIGN AND METHODS: A group of experts participated in a conference on 14-16 October 2013 cosponsored by the Endocrine Society and the American Diabetes Association. A writing group prepared t
To provide practical guidelines for the cytopathologic diagnosis of malignant mesothelioma.
Over recent years, several tissue engineering techniques are used for bone regeneration. In this study gelatin-hydroxyapatite (Gelatin-HA) cryogel scaffolds were used with/without bone morphogenetic protein-2 (BMP-2) and transforming growth factor beta-1 (TGF-beta 1) to heal critical sized bone defects. Release of growth factors from the cryogels were performed up to 28 days in vitro. Moreover, in
