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Human dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in pyrimidine de novo synthesis and represents a promising target for cancer therapy. However, current inhibitors of DHODH have limited clinical effectiveness and adverse effects. Herein, we report NK-A 17E-233I, a novel small-molecule inhibitor of the human DHODH enzyme, identified through a prospective virtual screening metho
Context In most cases of non-islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2, has been suggested to be coexpressed with IGF-II. Objective The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a
The European Spallation Source (ESS) is an intergovernmental project building amultidisciplinary research laboratory based upon the worlds most powerful neutron source. The main facility will be built in Lund, Sweden. Construction is expected to start around 2013 and the first neutrons will be produced in 2019. The ESS linac will deliver 5 MW of power to the target at 2.5 GeV, with a nominal curre
A reconfigurable digital root raised cosine (RRC) filter for a UMTS terrestrial radio access (UTRA) mobile terminal receiver is described and analysed. The filter monitors in-band and out-of-band received signal powers and calculates the appropriate filter length that meets the bit-energy to interference ratio (Eb/No). This design is advantageous, as only minimum battery power is used resulting in
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Popular Abstract in Swedish Mekanisk ventilation kan medföra "ventilationsinducerad lungskada" (VILI), som kan öka sjuklighet och dödlighet i samband med akut lungskada (ALI). Flera ventilationssätt har föreslagits för att undvika VILI, men inte slutgiltigt utvärderats. En princip är att öka alveolär ventilation och CO2-elimination genom att minska ventilationen av de skadliga rummet, dead space. Ventilator-induced lung injury (VILI) may contribute to morbidity and mortality of acute lung injury (ALI). Lung protective ventilation (LPV), that reduces VILI, may involve low tidal volume (Vt). Particularly low Vt is possible if dead space ventilation is reduced e.g. by aspiration of dead space gas (ASPIDS). ASPIDS implies that gas rich in CO2 during expiration is aspirated through a separate c
