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Despite the plethora of information on (S)-selective amine transaminases, the (R)-selective ones are still not well-studied; only a few structures are known to date, and their substrate scope is limited, apart from a few stellar works in the field. Herein, the structure ofLuminiphilus syltensis(R)-selective amine transaminase is elucidated to facilitate engineering towards variants active on bulki
Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
Background: Adverse childhood experiences (ACE) can have negative effects on cognitive, social and emotion regulation abilities, which can threaten the child’s school integration and capacity to learn. While steady relations to sensitive, understanding adults may moderate these negative outcomes, the difficulties of children with ACEs pose a major challenge for teachers, whose insufficient prepara
Background: Patients with bacteraemia caused by gram-positive bacteria are at risk for infective endocarditis (IE). Because IE needs long antibiotic treatment and sometimes heart valve surgery, it is very important to identify patients with IE. Objectives: In this narrative review we present and discuss how to determine which investigations to detect IE that are needed in individual patients with
Background: Recombination reshuffles alleles at linked loci, allowing genes to evolve independently and consequently enhancing the efficiency of selection. This makes quantifying recombination along chromosomes an important goal for understanding how selection and drift are acting on genes and chromosomes. Results: We present RecView, an interactive R application and its homonymous R package, to f
This paper presents a measurement of fiducial and differential cross-sections for W+W- production in proton–proton collisions at s=13 TeV with the ATLAS experiment at the Large Hadron Collider using a dataset corresponding to an integrated luminosity of 139 fb - 1 . Events with exactly one electron, one muon and no hadronic jets are studied. The fiducial region in which the measurements are perfor
Constructed wetland (CW), a green wastewater treatment technology, is extensively used in the world owing to its advantages of less investment, low energy consumption, simple operation and maintenance, and satisfactory purification effect. Currently, with the promotion of CW application, a variety of problems have been gradually exposed. This paper summarizes the common problems of CWs, including
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focusing on brain-mind development. The project aims to
Background: Insomnia is common in adolescents. This study evaluated feasibility and preliminary efficacy of a six-week internet-delivered cognitive-behavioral therapy for insomnia (ICBT-I) in adolescents. Methods: In this uncontrolled pilot study, participants (n = 27, 78% female) completed assessments pre- and post intervention. Data on recruitment, adherence to treatment, treatment activity, sat
Context. Extreme precision radial-velocity spectrometers enable extreme precision in stellar spectroscopy. Searches for low-mass exoplanets around solar-type stars are limited by various types of physical variability in stellar spectra, such as the short-term jittering of apparent radial velocities on levels of ∼2 m s-1. Aims. To understand the physical origins of radial-velocity jittering, the so
The demand for user participation in design processes is increasing, and there is a need to formulate guidance on how to involve disabled users and their representative organisations. Their participation contributes an extreme user perspective to the design process. The aim of this study was to develop an empirically grounded framework for user participation in co-design processes, involving the u
An Extended Triple Collocation for maximized Correlation (ETCC) method was proposed with a unique correlation function, the purpose of which is to maximize the correlation between the merged product and unknown truth. The method was tested over quasi-global land by combining three independent precipitation products. The performance of the ETCC-merged product was then evaluated against three refere
Diffraction-based tomographic strain tensor reconstruction problems in which a strain tensor field is determined from measurements made in different crystallographic directions are considered in the context of sparse matrix algebra. Previous work has shown that the estimation of the crystal elastic strain field can be cast as a linear regression problem featuring a computationally involved assembl
Introduction: Single Bicycle Brashes (SBCs) are common, and underreported in official statistics. In urban environments, light rail tram tracks are a frequent factor, however, they have not yet been the subject of engineering analysis. Method: This study employs video-based analysis at nine Dublin city centre locations and introduces a predictive model for crossing success on tram tracks, utilisin
Purpose: Positron emission tomography (PET) provides in vivo quantification of amyloid-β (Aβ) pathology. Established methods for assessing Aβ burden can be affected by physiological and technical factors. Novel, data-driven metrics have been developed to account for these sources of variability. We aimed to evaluate the performance of four of these amyloid PET metrics against conventional techniqu
