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Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: Tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to result in loss of cartilage proteoglycans, the source of tissue fixed charge density (FCD). In order to
Transcription factor-based biosensors represent promising tools in the construction and evaluation of efficient cell factories for the sustainable production of fuels, chemicals and pharmaceuticals. They can notably be designed to follow the production of a target compound or to monitor key cellular properties, such as stress or starvation. In most cases, the biosensors are built with fluorescent
Stormfloder är tillfälligt förhöjda vattennivåer orsakade av meteorologiska fenomen som kan ge upphov till översvämningar utmed kusten. När havsnivån stiger till följd av klimatförändringarna och befolkningen utmed kusten ökar, leder det till en ökad översvämningsrisk. Risk kan beskrivas som en kombination av sannolikhet och konsekvens. För att kunna bestämma var som är säkert att bygga och hur be
A reduced VAT rate can apply to works of art. However, the definition of art for this beneficial treatment can differ from the art definition experts use. This is especially the case with regard to photographs. The central question in this article is whether this different view can be based on inherent characteristics of VAT as the ECJ claims. In order to answer this question, the article starts w
Seven skeletal reaction mechanisms are presented to highlight key chemistry for mechanism reduction of small alcohol fuels at engine conditions. The mechanisms predict ignition delay times, laminar burning velocity, and extinction strain rate, within 5% of their corresponding complex mechanisms used as a start point for reduction. The mechanisms were developed for equivalence ratio range of 0.7–1.
Background: Photoacoustic (PA) imaging is an emerging non-invasive biomedical imaging modality that could potentially be used to determine the borders of basal cell carcinomas (BCC) preoperatively in order to reduce the need for repeated surgery.Methods: Two- and three-dimensional PA images were obtained by scanning BCCs using 59 wavelengths in the range 680-970 nm. Spectral unmixing was performed
This paper addresses the need for secure storage in virtualized services in the cloud. To this purpose, we evaluate the security properties of Intel's Software Guard Extensions (SGX) technology, which provides hardware protection for general applications, for securing virtual Hardware Security Modules (vHSM). In order for the analysis to be comparable with analyses of physical HSMs, the evaluation
One of the factors that can contribute to the resolution of long, doped inorganic scintillators used for nuclear spectroscopy is the variation of the dopant concentration over the length the detector crystal. In this work an investigation of such potential variations in one of the CsI(Tl) scintillators used in the calorimeter, CALIFA, of the R3B experiment at FAIR, has been performed using particl
A Soft X-ray FEL (the SXL) is currently being designed at the MAX IV Laboratory. In the work to adapt the FEL to the scientific cases several advanced options are being studied for coherence enhancement, generation of short pulses and two-color pulses. We will discuss the current status and initial results of the schemes studied, especially regarding the FEL performance with the features of the MA
Aims: Rodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental methods and strategies and to provide guidance on the proper interpretation of
Background: There is growing evidence that people with serious mental illness have impaired capacity for processing sensory inputs which affects daily occupation. Although this is known, research regarding the target groups experiences of sensory inputs in daily occupations is lacking. Aim: To investigate the experience of sensory input and strategies used in daily occupations among people with se
Background/Purpose: The need for transitional care has gained increased focus in the treatment of patients with congenital colorectal disorders. We aimed to acquire in-depth knowledge about the experiences of adult patients with Hirschsprung's disease (HD) and their suggestions for transitional care. Methods: Binational study applying gender equal focus group interviews (FGI). Results: Seventeen (
A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in di
Trycket på både skogs- och jordbruksmark ökar, bland annat som en följd av befolknings-ökningen, ändrade konsumtionsmönster och den pågående klimatförändringen. Detta leder till målkonflikter, där aktörer med olika intressen har olika syn på hur marken ska användas på bästa sätt. Dagens sektorsvisa planering, där beslut ofta tas på fastighetsnivå, gör det svårt att hitta lös
Multiple-input multiple-output (MIMO) is a key enabler for high data rates in mobile communications. However, it is challenging to design MIMO terminal antennas for LTE bands below 1 GHz, due to the conventional chassis offering only one resonant characteristic mode (CM). Recently, it was shown that minor structural changes can yield up to two additional resonant modes for designing two-port MIMO
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolutional restricted Boltzmann machines. We demonstrate experimentally that the meth
