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Popular Abstract in Swedish Sedan kartläggningen av det mänskliga genomet, har mer fokus lagts på dess produkt, proteomet, som definieras som de proteiner som uttrycks i en cell vid en viss tidpunkt. Proteomets dynamiska egenskaper gör det till en fantastisk källa för så kallade biomarkörer, det vill säga molekyler som genom deras koncentrationsmönster kan användas för att särskilja sjuka och frisMultiplex protein quantification, proteomics, is essential for uncovering new biomarkers and understanding biology. Liquid chromatography coupled to mass spectrometry (LC-MS) is the predominant technique for these measurements. In this thesis, optimization and quality control strategies for different phases of the LC-MS pipeline have been developed. Due to the inherent complexity and dynamic rang

Purpose: To assess the frequency of embolization into retrievable inferior vena cava (IVC) filters during catheter-directed thrombolysis (CDT) and stent placement for acute iliocaval deep venous thrombosis (DVT). Methods: Serial phlebograms from 40 patients (28 women; median age 32 years) consecutively treated with CDT for DVT during a 12-year period were retrospectively evaluated for visible embo

Motivation: The most common approach to estimate microbial diversity is based on the analysis of DNA sequences of specific target genes including ribosomal genes. Commonly, the sequences are grouped into operational taxonomic units based on genetic distance (sequence similarity) instead of genetic change (patristic distance). This method may fail to adequately identify clusters of evolutionary rel

In the wood-to-ethanol process, pretreatment of the material is necessary prior to enzymatic hydrolysis to obtain high overall yields of sugar and ethanol. Steam pretreatment of fast-growing Salix either with or without SO2 impregnation has been investigated by varying different parameters. Overall glucose yields of above 90% and overall xylose yields higher than 80% were obtained both with and wi

In the present study a HPAEC-PAD method is described that was developed for monitoring the consistency of N-glycosylation during the production and purification of recombinant proteins and monoclonal antibodies. The method successfully separated 18 neutral and sialylated oligosaccharides. Results obtained were compared with MALDI-TOF MS and it was shown that both methods gave similar results. in a

This paper illustrates the potential for reducing future electricity demand for air distribution in commercial buildings in Sweden. We have developed a general, quantitative, scenario-based framework to describe electricity demand for air distribution and to analyze how governmental and utility-sponsored policy measures affect electricity demand. The results suggest that higher electricity prices

This study is a long-term follow-up of a previously published study that used the internet in the rehabilitation of people on long-term sick leave owing to chronic pain and/or burnout. The follow-up was to assess the effects over time of this kind of rehabilitation. The goals of the first study were to improve the participants' health and work capacity. Sixty people were randomly assigned to eithe

The interest in economic evaluation of alternative strategies for haemophilia treatment has increased through the years. Few studies have actually been undertaken, however, and most of them have been simple cost-minimization or cost-effectiveness analyses. From the perspective of the binational project 'Treatment strategies for severe haemophilia - prophylaxis vs. on-demand', the present paper dis

The influence on the crack growth rate for a short edge crack under fatigue loading due to changes in crack length, grain size, load range and grain boundary configuration, is investigated under quasi-static and plane strain conditions. The geometry is modelled by distributed dislocation dipole elements in a boundary element method approach and the plasticity is described by discrete dislocations.

The concept of optical coherence tomography (OCT) for high-resolution imaging of tissues in vivo is introduced. Analytical and numerical models for describing and understanding the light propagation in samples imaged by OCT systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle and valid both for single and multiple scattering regi

BACKGROUND: Asthma guidelines recommend that long-acting inhaled beta-agonists should be used as maintenance therapy for patients with asthma inadequately controlled on an inhaled corticosteroid. We studied the safety and efficacy of the long-acting beta-agonist formoterol compared with terbutaline, each taken as needed, in patients with moderate to severe asthma. METHODS: Patients were taking an

The use of supercritical CO, (SC-CO2) for extracting alkylresorcinols from rye bran was investigated. For pure SC-CO2, 35 MPa and 55 degrees C were used. SC-CO2 with 10% ethanol or methanol as co-solvents was tested at four pressure levels (8, 15, 30 and 35 MPa) and two temperatures (40 and 55 degrees C). Experiments were conducted at a constant SC-CO2 flow of 5 g/min for 2 h. For comparative purp

Abstract in UndeterminedOn millennial or even centennial time scales, the activity of rapid flowing ice can affect climate variability and global sea level through release of meltwater into the ocean and positive feedback loops to the climate system. At the surge-type glacier Bruarjokull, an outlet of the Vatnajokull ice cap, eastern Iceland, extremely rapid ice flow was sustained by overpressuriz