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INTRODUCTION: Automated cerebrospinal fluid (CSF) biomarker assays have largely replaced manual immunoassays for measuring amyloid pathology in CSF. We refitted and validated the ABIDE model, predicting progression from mild cognitive impairment (MCI) to dementia, with CSF measurements from the automated Elecsys platform. METHODS: We included 2413 MCI participants (998 [41%] amyloid-positive) from
Take Home Message Using Germany as a case example, a comparison between organized mammography screening and contemporary, risk-adapted screening for prostate cancer suggests that prostate-specific antigen–based early detection with incorporation of magnetic resonance imaging and active surveillance can achieve benefits comparable to those of mammography while addressing previous concerns about ove
BACKGROUND: Since the first national guideline for managing obesity in adults and children in Canada was published in 2007, new evidence has emerged and guideline standards have evolved. Our purpose is to describe the protocol used to update the Canadian clinical practice guideline for managing pediatric obesity. METHODS: This guideline will update the pediatric components of the 2007 Canadian cli
Polyphagous insects rely on multiple cues to choose oviposition sites, including substrate temperature and nutritional quality, which often do not coincide. We examined how females of the invasive fly Drosophila suzukii make oviposition decisions when temperature and nutrition mismatch, and whether infection with the symbiotic bacterium Wolbachia influences these choices. We first quantified femal
Background:Trauma patients present with heterogeneous injury patterns that are challenging to represent in statistical models. Traditional approaches either use high-dimensional one-hot encoding, resulting in sparse features, or aggregate injuries into summary scores that lose patient-specific detail.Objective:This study developed data-driven ICD-10 embeddings for trauma injuries and evaluated the
Aim: This paper aims to describe what constitutes good-quality, accessible, affordable and acceptable primary care for migrants. This includes identifying system adaptations and offering evidence- and practice-based recommendations and guidance for primary care organizations and professionals on how to deliver such care.Background: Migration has significantly diversified European populations. Migr
Electrifying heavy-duty vehicles at large sites requires charging infrastructure designs that balance cost and robustness. This article quantitatively compares six different charging infrastructures, spanning centralized vs. decentralized layouts and AC vs. DC distribution through a case study of a 50-charger site (≈15 MW total). Capital costs (cables, converters, transformers) are modeled, and e
Public procurement has the potential to serve as a strategic driver for circular economy implementation and urban sustainability transitions. Purpose: This study explores how municipalities incorporate circular requirements into construction project procurement processes. The aim is to identify practical strategies that support circular implementation in construction projects. Methodology: U
Modern battery chargers require AC-DC converters with high input power quality, nearly unity power factor, and low current harmonics to meet grid standards such as IEC 61000-3-2. This paper proposes a two-stage charger topology: a front-end bridgeless interleaved boost PFC converter followed by a synchronous buck DC-DC stage. The interleaved boost stage reduces input current ripple and losses whil
The neoliberal turn in the cultural and creative industries has led to two distinct bodies of work. Global North scholars focus on the tension between the emphasis on the creative industries as an engine of growth and the unequal access to the means of cultural production and consumption that neoliberalism presents. Global South scholars face a different reality; the increasing inability of govern
Many cities in the Global South are facing challenges as they increasingly experience extreme weather events, which disproportionately affect the urban poor. Focussing on severe heat and surface water flooding, this paper explores how these extreme weather events impact on infrastructure provision and livelihoods in low-income urban communities in Ghana. Climate series, including temperature data
Autonomous robots capable of turning natural-language instructions into reliable physical actions remain a central challenge in artificial intelligence. Here we show that connecting a large language model agent to the robot operating system enables a versatile framework for embodied intelligence, and we release the complete implementation as freely available open-source code. The agent automatical
We introduce a two-phase quadratic integrate-and-fire (QIF) neuron whose membrane potential evolves according to two alternating Riccati equations within finite bounds. This simple extension removes the unphysical voltage divergence of the standard QIF model while producing realistic spike waveforms. Despite this modification, the system retains an exact low-dimensional description in the thermody
INTRODUCTION: Resection of intraductal papillary mucinous neoplasm (IPMN) aims to prevent progression to invasive pancreatic cancer. However, the risks of pancreatic surgery and frequent findings of low-grade dysplasia (LGD) raise concerns about overtreatment. This EAHPBA-endorsed multinational study evaluated short- and long-term overall survival (OS) following preventive resection for IPMN (with
