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The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘proto
Transportation equity is vital for the fulfillment of citizens’ activities. To make better decisions for transportation planning, it is appropriate to have a method to evaluate each mode and assign an equity score to it. This paper aims to propose a method to assess the level of equity using different transportation modes in each zone of a city. Here, the equity level takes into account on one sid
We study the long-time behavior of solutions to quasilinear doubly degenerate parabolic problems of fourth order. The equations model, for instance, the dynamic behavior of a non-Newtonian thin-film flow on a flat impermeable bottom and with zero contact angle. We consider a shear-rate dependent fluid the rheology of which is described by a constitutive power law or Ellis law for the fluid viscosi
The COVID-19 pandemic is a crisis that is "creeping" in its onset and "slow-burning" in its duration. It is characterized by extreme uncertainty, ambiguity, and complexity, presenting an unprecedented need for response across sectors and political-administrative levels. While there has been an explosion of research papers into the national strategies for handling the pandemic, empirical publicatio
Introduction. The cure rate of early stage Hodgkin's lymphoma (HL) is excellent; investigating the late effects of treatment is thus important. Esophageal toxicity is a known side effect in patients receiving radiotherapy (RT) to the mediastinum, although little is known of this in HL survivors. This study investigates the dose to the esophagus in the treatment of early stage HL using different RT
In this paper we propose a shared regression network to jointly estimate the pose of multiple objects, replacing multiple object-specific solutions. We demonstrate that this shared network can outperform other similar approaches that rely on multiple object-specific models by evaluating it on the TLESS dataset using the VSD (Visible Surface Discrepancy). Our approach offers a less complex solution
It has been shown that ultra-high frequency (UHF) ultrasound applied to the external bowel wall can delineate the histo-anatomic layers in detail and distinguish normal bowel from aganglionosis. This would potentially reduce or lessen the need for biopsies that are currently mandatory for the diagnosis of Hirschsprung’s disease. However, to our knowledge, no suitable rectal probes for such a use a
The dynamic interaction between a non-viscid, compressible fluid and an elastic structure is studied. Finite element formulations, using the weighted residual method, are derived. Different primary variables in the fluid domain are used and different source functions are considered.When a potential field is used, the dynamic interaction between fluid and structure yields nonsymmetric matrices. In The dynamic interaction between non-viscid, compressible fluid and an elastic structure is studied. Finte element formulations, using the weighted residual method, are derived. Different primary variables in the fluid domain are used and different source functions are considered.When a potential field is used, the dynamic interaction between fluid and structure yields nonsymmetric matrices. I addi
In recent years, social work with migrants and ethnic minorities has developed as a field of research and practice. Further, it is recognised in the literature that the increased processes of human mobility in today’s societies have driven a growing focus on inclusive cities, especially in larger urban areas where ethnic diversity and cultural heterogeneity can be found alongside newly arrived mig
The TRPV1 receptor (transient receptor potential vanilloid 1) is a nonspecific membrane-bound cation channel, which plays an important role in nociception and pain transmission, the nerve-response to possibly dangerous stimuli. It is known that TRPV1 can be modulated by a variety of stimuli, amongst which heat, protons and chemical compounds, such as capsaicin, are the most known activators. This
Life-sciences have developed at a rapid pace during recent years. From experiments investigating single molecules such as proteins or single genes to large scale projects mapping entire organisms in one single experiment. However, data generated from this kind of large scale projects need to be interpreted and integrated with the base of prior knowledge in an efficient, reliable and correct way. T
The Swedish power grid is actively balanced in order to maintain the nominal frequency of 50 Hz. Today, this is mostly done through flexible power generation. Emerging markets, allowing consuming resources to participate in balancing the grid, have the potential to increase the stability of the grid. This master thesis aimed to investigate the consequences and possibilities of using variable air v
Knowledge inequalities persist between the Global North and the Global South, but also within countries between privileged and underprivileged segments of society. The purpose of this study is to understand the motives of researchers from basic science and technology to investigate on socially demanded issues as well as the obstacles they encounter. The study is based on the experiences from eleve
As commodities are becoming more popular and accessible assets for speculative and hedging purposes, the limited research regarding risk management for said asset-class justifies further contribution to the deficient output. Many previous studies have highlighted the extraordinary high volatility, with non-linear and clustering characteristics associated with commodities. Hence, incorporating vola
Thesis purpose: The purpose of this study is to gain knowledge about baby boomers’ motivations for using either digital or analogue touchpoints in the high involvement customer journey. This ultimately contributes to an increased understanding of the high involvement customer journey. Methodology: A qualitative study with social constructionism as the research philosophy, where an abductive appro
To optimize the weights in an artificial neural network most methods rely gradients, which are not always obtainable or desirable. Evolutionary algorithms are instead based on Darwinian evolution where no derivative is needed. These algorithms have a set of strategy parameters that can be dynamically updated during the search to increase performance. Two ways of updating the parameters are the so
Styvhetsförändringar i bröstvävnad är ofta kopplade till en patologisk förändring. Vissa cancertyper som infiltererande duktalt carcinom kan vara åtta gånger så styv som fettvävnaden runt omkring. Genom att komprimera bröstet och mäta trycket på bröstets yta har man identifierat att det blir en lokal förhöjning i tryck där det finns en tumör. Med hjälp av den här typen av mekanisk avbildning av brA change in stiffness of breast tissue is often connected to a pathological change. Some types of breast cancer such as infiltrating ductal carcinoma can be up to eight times stiffer than fat tissue. It has been found that during compression of the breast there will be a local area of relatively high stress at the breast surface at the location of a tumour. This type of mechanical imaging of the b
This Master’s thesis investigates if a previously integrated Simulink based vehicle model works for testing and verifying software on an ECU (electronic control unit) used to control a four-wheel drive coupling in cars. The testing is done through a specific program called CANoe that allows the tester to both develop and run test cases. This work also investigates the possibility to use static eva
