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Recent years have seen a sharply rising interest in the scientific area dedicated to the study of the use of Artificial Intelligence (AI) for Cognitive Behavioral Therapy (CBT) research and applications (AI4CBT for brevity). Yet, little is known about how this interest is realized and hence the overall status, prospects, and possible challenges of AI4CBT as a field (e.g. breadth of the field, key
Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and
With the emergence of autonomous vehicles comes the requirement of adequate and rigorous testing, particularly in critical scenarios that are both challenging and potentially hazardous. Generating synthetic simulation-based critical scenarios for testing autonomous vehicles has therefore received considerable interest, yet it is unclear how such scenarios relate to the actual crash or near-crash s
INTRODUCTION: Biomarkers play a crucial role in understanding Alzheimer's disease (AD) pathogenesis and treatment effects. However, comparing biomarker measures without standardization and appreciating their magnitude relative to the disease can be challenging. METHODS: To address this issue, we propose the CentiMarker approach, similar to Centiloid, which provides a standardized scale between nor
I en tid präglad av konvergenskultur har en undervisningsdesign baserad på transmedialitet skapats för studenter på ämneslärarprogrammet i svenska för att dels visa på alternativa sätt att analysera dikter, dels visa på alternativa sätt att undervisa i lyrik och lyrikanalys och därigenom vidga den litteraturdidaktiska repertoaren för framtidens ämneslärare. Syftet m
A new sampling method, termed negligible depletion hollow fiber-protected liquid-phase microextraction, was developed for sensing the freely dissolved concentration (C free) and evaluating the availability of atrazine (ATR), desethyl atrazine (DEA), and simazine (SIM) in water. The sampling device was prepared by impregnating 1-octanol to both the pores and the lumen of a piece of polypropylene mi
This study aims at describing and analysing what kinds of social services are provided for physically abused children in Sweden. The social services files were examined for 113 children under 15 years of age (67 boys and 46 girls) who had been reported to the police as having been physically abused by a parent or equivalent caretaker in a particular police district. The children's social services
The extractability of phosphorus (P) was studied in an acid, unfertilized soil at an abandoned farm and in 40 different soils from former agricultural fields and pastures. Oxalate/Oxalic acid extraction was compared with a number of other methods in order to evaluate the suitability of oxalate/oxalic acid as a method for extracting P from soil. The extracting efficiency and a rough estimate of the
Polysulfones and polyphenylsulfones having pendant phenyl groups with sulfonic acid units have been prepared by lithiation of the respective polymer, followed by reaction with 2-sulfobenzoic acid cyclic anhydride. The resulting ionomers were cast into membranes and properties such as thermal stability, ion-exchange capacity, water sorption and proton conductivity were evaluated. These membranes pr
Five protected analogues of beta-D-galctosyl-(5R)-5-hydroxy-L-lysine were prepared, in which the galactosyl moiety was modified by monodeoxygenation or inversion of stereochemistry at C-4. The building blocks were used in the solid-phase synthesis of a set of glycopeptides related to the peptide fragment CII256-273 from type II collagen. Evaluation of the glycopeptides revealed that T-cell hybrido
The proposed adaptive frequency domain finite element (FE) model makes it possible to simulate wave propagation in a pavement structure over a wide frequency range using a normal size computer. The geometry and mesh size are optimized and regenerated for each frequency using a simple script in a commercial FE software package. Results from the FE model agree well with normal mode dispersion curves
Type 2 diabetes is one of the world’s major challenges today. Over 400 million people around the globe are diagnosed with diabetes and the consequences to the individual patient and health care systems are significant. Diabetes is a chronic disease and the standard treatment including lifestyle changes, metformin and insulin is in many cases not effective enough. New anti-diabetic drugs have been Type 2 diabetes is one of the world’s major challenges today. Over 400 million people around the globe are diagnosed with diabetes and the consequences to the individual patient and health care systems are significant. Diabetes is a chronic disease and the standard treatment including lifestyle changes, metformin and insulin is in many cases not effective enough. New anti-diabetic drugs have been
The incidence of tendon injury (tendinopathy) has increased over the past decades due to greater participation in sports and recreational activities. But little is known about the aetiology of tendon injuries because of our limited knowledge in the complex structure-function relationship in tendons. Computer models can capture the biomechanical behaviour of tendons and its structural components, w
Butikskedjorna inom dagligvaruhandeln är viktiga aktörer i arbetet med att förbättra ekologiska och sociala aspekter av livsmedelsförsörjningen och även för att uppmuntra till hållbara produkter på marknaden. Med tanke på deras stora inflytande på andra aktörer i produktkedjan i hållbarhetsarbetet tillskrivs butikskedjorna ofta benämningen grindvakt. Denna position innebär också f
Different designs of the SX-700 plane grating monochromator have been investigated for the undulator beamline (51) by using analytical considerations and carrying out ray tracing calculations. The most important modifications of the original design are those where the ellipsoidal focusing mirror has been replaced by a plane elliptical or by a spherical mirror. A significant advantage of the spheri
Scientific performance is often evaluated by bibliometric indicators such as publication counts or citations. But this may neglect other relevant outputs from research units. An optimal evaluation would measure each dimension separately, but this would be costly. Luckily, cluster analyses show that units which specialise in other types of research activities (such as knowledge transfer or educatio
The formation age of the large (∼50 km) Carswell impact structure, Canada, has been a matter of debate ever since its discovery five decades ago, with proposed ages ranging from Mesoproterozoic to Early Cretaceous. Here, we present new 40Ar-39Ar data for aliquots of euhedral adularia, separated from vesicles in an impact melt rock from the central uplift of the structure. The analyses of the adula
