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Parkinson's disease (PD) is characterized by a set of motor symptoms that depend on nigrostriatal dopaminergic degeneration and respond well to pharmacological dopamine replacement using L-DOPA. However, replacing dopamine with either L-DOPA or dopamine receptor agonists leads to the appearance of motor and nonmotor complications within a few years. Strong emphasis is currently placed on developin

BackgroundSome patients scheduled for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) only undergo explorative laparotomy (open/close procedure) due to extensive tumor spread or challenges in achieving complete cytoreduction (CC0). This study aimed to evaluate the surgical outcomes and overall survival in patients with peritoneal surface malignancy (PSM) who only

Vitamin A deficiency (VAD) remains a severe health issue in sub-Saharan Africa, causing blindness, illness, and child mortality. In Mozambique, about 69% of children under five are affected, highlighting the short-term impact and donor dependence of supplementation programs. Mangoes (Mangifera indica L.), rich in provitamin A carotenoids, offer a sustainable, food-based strategy to reduce VAD, but

Modern imaging atmospheric Cherenkov telescopes have extensively observed young nearby supernova remnants (SNRs), with ages of about 1000 years or less, in the very-high-energy (VHE) gamma-ray band. These efforts resulted in the detection of VHE emission from three young SNRs – Cassiopeia A, Tycho, and SN 1006 – and provided significant evidence for emission from the more distant Kepler’s SNR. How

Mechanisms of the aerosol indirect effects (AIEs) from ice nucleating particles (INPs) are investigated with the cloud-resolving “aerosol–cloud” (AC) model with a hybrid bin–bulk microphysics scheme coupled with a radiation scheme in 1) continental deep convection observed during the Midlatitude Continental Convective Clouds Experiment (MC3E) over Oklahoma and 2) supercooled stratiform clouds obse

Background and hypothesis Knowledge regarding access to first kidney transplantation (KT) and subsequent KT in patients commencing kidney replacement therapy (KRT) in childhood is limited. Methods Using European Renal Association (ERA) Registry data, we investigated European patients who started KRT below 20 years of age between 1978 and 2019. Access and determinants to first, second, and third KT

Thermal runaway in lithium-ion battery cells poses significant safety risks due to rapid heat generation and potential thermal propagation within a battery system. This study investigates the total heat released and the fraction of energy contained in gas and particles ejected during thermal runaway using a purpose-built calorimeter setup. The results show that the fraction of ejected heat is sign

This study succeeded to prepare three pure phases of Mn2O3, Mn3O4 beside one of the best cathode materials, spinel LiMn2O4. LiMn2O4 with high phase purity and crystallinity was synthesized by a facile, cost effective and one step synthesis method. The structure and morphology of the powders were studied in detail by means of X-ray diffraction (XRD), thermogravimetric analysis (TGA), field emission

The development and application of Electrochemical Quartz Crystal Microbalance (EQCM) sensing to study metal electroplating, especially for energy storage purposes, are reviewed. The roles of EQCM in describing electrode/electrolyte interface dynamics, such as the electric double-layer build-up, ionic/molecular adsorption, metal nucleation, and growth, are addressed. Modeling of the QCM sensor is

The integration of machine learning (ML) into software operations (MLOps) has significantly increased the demand for data to train and test models, making data sharing and reuse essential to mitigate the high costs of data collection and preprocessing. This study aims to advance the understanding of data sharing within an MLOps context by examining the establishment and governance of a data ecosys

This article distills the vast literature on Common Correlated Effects (CCE), initiated by the seminal contribution of Pesaran (2006), into five practical lessons. We provide a concise overview of the CCE framework and describe the reasons for its popularity in empirical (macro-) panel data research. The lessons we draw focus on aspects that have received substantial methodological attention, but

Alternative Economic Models (AEMs) are theoretical frameworks that, if implemented, could fundamentally transform economic systems by aligning financial objectives with sustainability goals. Conducting rigorous research on future-oriented AEMs and other complex sustainability systems presents challenges, particularly due to the exploration of largely unverifiable future possibilities. Qualitative

The article discusses the development and application of the so-called “stigma engagement strategy (SES)” in interviews with stigmatized study populations, drawing on an interview study with Swedish men who have paid for sex. SES is a qualitative methodological approach that utilizes external sources of stigmatizing narratives, such as newspaper articles and columns, as textual probes within inter

Introduction Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often termed treatment-resistant depression (TRD) and is seen in over one-Third of people with MDD. Reasons for treatment resistance are not well established, nor is the definition of TRD. Duration and se

Developing and validating sensitive visual read algorithms for assessing Alzheimer disease-related tau in tau PET imaging is imperative, considering the implementation of the methodology in clinical practice and trials. Our aim was to compare 2 visual read algorithms for tau PET images to semiquantitative measurements and plasma phospho-tau 217 (p-tau217) status. Methods: In total, 1,654 participa

Biobased polyesters are emerging as sustainable alternatives for hot-melt adhesives (HMAs) owing to their tunable adhesion properties, facile processing, and versatile end-of-life options. Here, we report on the design of low-temperature (100 °C) HMAs, derived from oxygen-rich lignin-based copolyesters synthesized via copolymerization of a syringic acid-derived aromatic monomer with biobased aliph

Background: Joint pain and chronic back pain are highly prevalent in the aging population and have a large impact on life quality. As the underlying mechanisms are not fully understood, this exploratory cross-sectional study aimed to discover proteins and pathways associated with these two pain conditions in Swedish 70-year-old men. Methods: Plasma proteins (n = 720) were measured in participants

Populations are presumed to be adapted to local environmental conditions via natural selection, with gene flow breaking up local adaptations. In birds, various aspects of feathers may reflect local adaptation. For example, the insulation capacity of feathers could be greater in colder regions, while colour variation may also play a role in adapting to local environmental conditions since darker fe