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The present study evaluated the combination of antithymocyte globulin (ATG) and cyclosporine A (CsA) in patients with low-risk myelodysplastic syndromes. Twenty patients (17 with refractory anemia and 3 with refractory anemia with excess blasts) received treatment with rabbit-ATG plus CsA. The overall response rate was 30% (6/20); three of the six responders had a complete response. The responses

Reactive oxygen intermediates are important mediators of inflammation. We investigated if hydrogen peroxide (H2O2) induces tumour necrosis factor alpha (TNFalpha) expression in cultured human cells from umbilical vein endothelium (HUVEC), aortic smooth muscle cells (SMC), peripheral blood mononuclear cells (PBMC), or the cell line Mono Mac 6. Cultures were stimulated with 200 micromol/L H2O2 for 1

The ellipsoidally symmetric extension of Buda-Lund hydrodynamic model is shown here to yield a natural description of the pseudorapidity dependence of the elliptic flow upsilon(2)(eta)), as determined recently by the PHOBOS experiment for Au + Au collisions at root(S)NN = 130 and 200 GeV. With the same set of parameters, the Buda-Lund model describes also the transverse momentum dependence of upsi

Popular Abstract in Swedish Vår konsumtion av varor ger nytta på ett flertal sätt. Men samma varor ger också upphov till olika former av miljöpåverkan genom hela deras livscykel (från råvaruutvinning till slutligt omhändertagande). Vi vet erfarenhetsmässigt att det är bättre att förebygga ett problem än att reparera skadan efteråt och på samma sätt förhåller det sig med miljöproblemen. När det gälPolicies based upon Extended Producer Responsibility (EPR) aim to reduce the environmental impacts of products across their entire life cycle. The intent is to induce design changes in products and thus reduce impacts at source. This, by provision of incentives to producers through an extension of responsibility. Since the early 1990s, a number of countries have incorporated the concept of EPR int

The success of large scale relativistic multiconfiguration Dirac-Hartree-Fock calculations for atomic systems rely on judiciously chosen configuration expansions. Dependent on the atomic system as well as on the studied properties, various correlation effects need to be considered. Based on the active set approach, this program allows the user to generate general lists of j j-coupled configuration

Introduction: Complex production systems as, for instance, those used in health care, in off shore industry, in nuclear power industry or in aviation suffer now and then from severe system breakdowns. Lessons learnt from these often lead to changes in the "system". A more rational approach would be to identify these "system weaknesses" before accidents happen. A new proactive method, DEB analysis,

Higgs boson production with subsequent decay to photons was searched for in the data collected by the DELPHI detector at centre-of-mass energies between 183 GeV and 209 GeV, corresponding to a total integrated luminosity of nearly 650 pb(-1). No evidence for a signal was found, and limits were set on h(0)Z(0) and h(0)A(0) production with h(0) decay to photons. These results were used to exclude re

Laser-induced fluorescence (LIF) has been developed for visualization of fuel distribution fields in an operating spark-ignition (SI) engine. Since the standard research fuel iso-octane, does not yield a useful LIF signal a fluorescent additive was used. None of the commonly used seeds were found adequate. A seed not commonly used in this context, 3-pentanone, C2H5COC2H5, was chosen due to favorab

No abstract available.

The aim of this study was to model the effect of short (3 year) treatments for osteoporosis at different times after menopause on the risk of osteoporotic fracture and to assess the impact of strategies to target high-risk individuals. Treatment efficacy for hip, proximal forearm, shoulder, and spine fracture were computed from the relationship between bone mineral density (BMD) and fracture in wo

In this study we have developed and validated a novel approach of transgene regulation in the brain. By using lentiviral vectors that incorporate promoters of genes that are up-regulated during different pathological states, we were able to regulate transgene expression in accordance with the disease process. When using a glial fibrillary acidic protein promoter, efficient disease regulation in gl

An axillary brachial plexus nerve block by a transarterial approach is commonly used to achieve regional anaesthesia for hand surgery. We designed a retrospective study to evaluate efficacy and safety of the technique for acute and elective operations. Anaesthetic records of 189 of all 5520 patients (1996-2000) who had axillary brachial plexus blocks for hand surgery were reviewed, and results com

Incidence of cardiovascular (CV) and metabolic disease is increasing, in parallel with associated risk factors. These factors, such as low-density lipoprotein (LDL)-cholesterol, elevated blood pressure, obesity, and insulin resistance have a continuous, progressive impact on total CV risk, with higher levels and numbers of factors translating into greater risk. Evaluation of all known modifiable r

Pancreatic cancer is strongly associated with the development of hyperglycemia, peripheral insulin resistance and diabetes mellitus, especially when presented as new-onset diabetes mellitus. Peripheral insulin resistance and hyperinsulinemia have been suggested to promote growth of pancreatic cancer cells, and therefore a relation between long-standing diabetes mellitus type 2 and pancreatic cance