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The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. In a bivariate analysis combining the nevus results with a recent mela
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a novel animal model. A calcium sulphate (CS)/hydroxyapatite (HA) carrier was used to deliver a bisphosphonate, zoledronic acid (ZA), locally, with or without added recombinant human bone morphogenic protein-2 (rhBMP-2). Twenty-eight-week-old ovariectomized Sprague-Dawley rats were used. A 1 mm diameter
The intensification of agricultural practices throughout the twentieth century has had large detrimental effects on biodiversity and these are likely to increase as the human population rises, with consequent pressure on land. To offset these negative impacts, agri-environment schemes have been widely implemented, offering financial incentives for land-owners to create or maintain favourable habit
Direct laser writing (DLW) has arise interest in a variety of fields due to the capabilities that we get from the realization of 2D and 3D structures with high resolution fabrication techniques. Multi-photon lithography (MPL) relies on non-linear absorption effects, making possible the fabrication of metasurfaces with feature size beyond the diffraction limit. A new approach in this direction is t
Single-cell technologies have transformed our understanding of cellular heterogeneity through multimodal data acquisition. However, robust cell alignment remains a major challenge for data integration and harmonization, including batch correction, label transfer, and multi-omics integration. Many existing methods constrain alignment based on rigid feature-wise distance metrics, limiting their abil
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IntroductionSport-related concussion (SRC) is a pressing issue in Para sport, yet biomechanical mechanisms remain poorly understood. Athletes with visual impairment face elevated risks due to sport-specific demands, such as frequent collisions in blind football. This pilot study examined head acceleration responses in blind football players compared with non-disabled football players, and between
IntroductionSport-related concussion (SRC) is a major health concern in contact sports. Linear head acceleration (LHA) and rotational head acceleration (RHA) are central biomechanical markers, and anticipatory neck muscle activation may mitigate these forces. Evidence on how anticipation influences head kinematics, and whether sex differences exist, remains limited. This study compared head accele
The production of fast pyrolysis bio-oil (FPBO) from secondary biomass is a promising technique for the production of liquid biofuels. However, the resulting FPBO is often viscous and chemically unstable, requiring significant upgrading while also being difficult to work with. To overcome this issue, FPBO can be hydrotreated using slurry hydrotreatment, which has a long history as a processing tec
For a system with interacting quantum mechanical particles in a one-dimensional harmonic oscillator, a trial wavefunction with simple structure based on the solution of the corresponding two-particle system is suggested and tested numerically.With the inclusion of a scaling parameter for the distance between particles, at least for the very small systems tested here the ansatz gives a very good es
Arterial stiffness is an independent risk factor for cardiovascular morbidity and can be assessed by applanation tonometry by measuring pulse wave velocity (PWV) and augmentation index (AIX) by pressure pulse wave analysis (PWA). As an inexpensive and operator independent alternative, photoelectric plethysmography (PPG) has been introduced with analysis of the digital volume pulse wave (DPA) and i
Cemented carbides with tungsten carbide grains as hard phase and metallic cobalt binder phase are used extensively for drill bit inserts for rock drilling. The process of rock drilling is severe with some of the wear happening through fracture in the cemented carbide. This work investigated two cemented carbides with iron rich alternative binder phases containing different amounts of FCC phase, in
NaOH and NaCl vapor are key alkali compounds released during the thermal conversion of high-alkali coal and municipal solid waste, and their accurate measurement is crucial for understanding the mechanisms of ash deposition, slagging, and other related issues. However, in-situ and species-specific measurement techniques with high sensitivity for NaOH and NaCl molecules in hash combustion environme
The aim of this study was to explore the potential of using existing environmental moni-toring data as a basis for environmental certification of farms within primary agricultural production. Three research questions guided the work: which indicators of agricultural environmental impact can be identified in available monitoring data, which criteria these data must meet to be applicable in a certif
Driver applications are increasingly used in professional driving to support route planning, order management, documentation, and communication. When drivers need to read, interpret, or interact with information in close proximity to driving, these systems can also create visual, manual, and cognitive distractions, increasing traffic safety risk. This master's thesis was conducted in collabora
Bacterial infection and hemorrhage remain significant clinical challenges for chronic wounds, despite advancements in antimicrobial strategies and materials. Herein, 980 nm-laser-responsive photothermal conjugated polymers (CPs) are combined with chitosan-based cryogels (CP@Gel) to achieve rapid hemostasis and efficient anti-infectious performance. CP nanoparticles (CP NPs) were prepared by nanopr
Aerosolised Polystyrene Latex (PSL) nanoparticles are, due to their well-defined size, spherical shape, and inert surface, useful in many experimental applications, including studies of particle deposition in the human lung. Aerosolising nanoparticles entails added challenges, and nanoparticles can potentially be more hazardous than otherwise equivalent microparticles. The objective of this work w
We report on the experimental investigation of potential high-performance cavity length stabilization using odd-indexed higher-order spatial modes. Schemes based on higher-order modes are particularly useful for micro-cavities that are used for enhanced fluorescence detection of a few emitters, which need to minimize photons leaking from a stabilization beam. We describe the design and constructio
