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BACKGROUND: Mitochondrial dysfunction is a hallmark of cancer. However, it is unclear whether it is a cause of cancer. This two-sample Mendelian randomization (MR) analyses, uses genetic instruments to proxy the exposure of mitochondrial dysfunction and cancer summary statistics as outcomes, allowing for causal inferences.METHODS: Summary statistics from 18 common cancers (2107-491,974 participant
Background: Autoimmune diseases are associated with many cancers but there is a lack of population-based studies with different autoimmune diseases that have a long follow-up. This is also true of hepatobiliary cancers, which include hepatocellular cancer (HCC) and rarer entities of gallbladder cancer (GBC), intra- and extrahepatic cholangiocarcinoma (iCCA and eCCA), and ampullary cancer. Methods:
We present a computational framework to simultaneously perform image acquisition, reconstruction, and analysis in the context of open-source microscopy automation. The setup features multiple computer units intersecting software with hardware devices and achieves automation using python scripts. In practice, script files are executed in the acquisition computer and can perform any experiment by mo
Standard ZYMO DNA/RNA miniprep extraction protocol written in a user friendly way to reduce in-process-decisions and process time
BackgroundPatients with advanced ovarian cancer (AOC) who undergo primary and interval debulking surgery are often anemic at diagnosis, with iron deficiency being the most common cause. The aim was to investigate whether preoperative anemia and iron deficiency impact short-term recovery.MethodsThis retrospective cohort study included 262 patients with AOC who underwent surgery at Skane University
Micro-LEDs have emerged as a hot research topic due to their potential for next-generation display and lighting applications, necessitating advanced characterization techniques to optimize their performance. This study demonstrates the advantage of cathodoluminescence in the scanning electron microscope to be a critical tool for the optical characterization of InGaN platelets with red quantum well
Direct laser writing (DLW) has arise interest in a variety of fields due to the capabilities that we get from the realization of 2D and 3D structures with high resolution fabrication techniques. Multi-photon lithography (MPL) relies on non-linear absorption effects, making possible the fabrication of metasurfaces with feature size beyond the diffraction limit. A new approach in this direction is t
Single-cell technologies have transformed our understanding of cellular heterogeneity through multimodal data acquisition. However, robust cell alignment remains a major challenge for data integration and harmonization, including batch correction, label transfer, and multi-omics integration. Many existing methods constrain alignment based on rigid feature-wise distance metrics, limiting their abil
Fler än 800 000 svenskar har privata sjukvårdsförsäkringar, men effekten detta har på svensk sjukvård och jämlikhet går inte att följa i svenska register.
IntroductionSport-related concussion (SRC) is a major health concern in contact sports. Linear head acceleration (LHA) and rotational head acceleration (RHA) are central biomechanical markers, and anticipatory neck muscle activation may mitigate these forces. Evidence on how anticipation influences head kinematics, and whether sex differences exist, remains limited. This study compared head accele
This article offers a reconsideration of religious mobilisation in the inter- and postwar periods. It focuses on how the Church of Sweden gradually altered its catechetical activities aimed at children to meet changing needs. Built on a range of statistical sources, this article calls for a reconsideration of the ways in which larger Protestant denominations adjusted to meet declining religious pr
Health care is moving toward integrated services where care and rehabilitation are provided at home rather than in institutions. This, together with the requirement that care must be person-centered, has proven to be a considerable challenge. Older adults living with complex health conditions such as stroke are vulnerable to change when their responsibility for care and rehabilitation becomes exte
The third generation of innovation policy focusing on addressing societal challenges requires collaborative engagement and action across a broad base of stakeholders over time to contribute to ambitious missions and transform societal systems. The strategic governance of such collaborative work in innovation ecosystems requires a collective vision and direction, a shared view on what to do, and a
Abstract in NorweiganSammenfatning: Spørsmålet om identitet er alltid tilstedei akademiske og ikke-akad-emiskediskurser om religion og interreligiøse relasjoner: identitet som en kategori av noe som kan spigles fast, etableres ogopprettholdes ved hjelp av de"nisjonerog logikk; identitet som et spørsmål om noe stabilt og til og med rigid. Detteer viktig i overveielser omsynkretisme. I denne artikkeThe matter of identity is ever present in academic, and non-academic, discourses on religion and interreligious relations: identity as a category of something that can be nailed down, established and maintained with the help of definitions and logic; identity as a matter of something stable and even rigid. This is significant in deliberations regarding syncretism. In this paper, references are mad
Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic drugs with novel mechanisms of action. However, realizing its full potential for biologics discovery requires new technologies to produce antibodies to all, a priori unknown, disease-associated biomolecules. We present a methodology that helps achieve this by integrating computational modeling, differential antib
How can offender supervision in the execution of state-sanctioned punishment integrate instances of democratic emancipation and thereby inspire participatory citizenship for disenfranchised clients?This project balances an interest in social work and its prospects for delivering emancipation through motivational agency, on the one hand, with an attentiveness to recent developments in Scandinavian
