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Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but continues to be expressed into adulthood. In Parkinson's disease, Nurr1 expression is dimin
Despite the potentially strong effect of wind on bird orientation, our understanding of how wind drift affects migrating birds is still very limited. Using data from satellite-based radio telemetry, we analysed the effect of changing winds on the variation of the track direction of individual birds. We studied adults and juveniles of two raptor species, osprey Pandion haliaetus and honey buzzard P
Background: In a previous smaller study, we found evidence of a diminished global coagulation capacity after maximal exercise in patients with severe haemophilia A (HA). Aim: To validate these results, we repeated the study in a larger cohort. We also examined if the exercise-induced increased levels of von Willebrand factor (VWF) might prolong the effect of factor concentrate administered just be
Talent Management is a vague concept that is covering everything from recruiting, developing and retaining talents within organisations. A constant challenge in this field is to develop new generations within the workforce to fit what the organisation needs in order to do business. Generations are said to be shaped after historical and political factors that are impacting their behaviors and requi
There has been considerable scepticism in Europe over the reliability of Russia as a secure source of energy for the EU. Despite Russia and EU being economically interdependent with regard to energy and other trade, there is still concern over potential supply disruptions. What can be gathered from media and scholarly sources is that Russia is potentially an unreliable supplier yet it is currently
Will developing countries benefit economically from strengthening their protection of intellectual property? They have been repeatedly urged to do so by developed nations. But so far there is little empirical experience of either quite successful or failed examples. What we could hear from the media seems that the international protection of IPRs is getting stricter and more codified, while the si
Calculus of variations is a branch of mathematics that was developed in the 18th century to solve problems of determining optimal trajectories, shapes and structures subject to constraints. It deals with the minimization of a certain type of integral functional. In the early days of the theory, the smoothness of the functions involved was assumed but, during the following centuries, advances in an
Despite global modern economic growth, most countries remained stuck in persistent poverty. Jeffrey Sachs suggested considering poverty itself as the explanation for persistent levels of poverty and low growth. The theory is based on the existence of poverty traps, which keep families and countries caught in poverty. This research contributes to the poverty trap literature by evaluating the effect
The Homeobox (Hox) transcription factors are important regulators of normal and malignant hematopoiesis because they control proliferation, differentiation, and self-renewal of hematopoietic cells at different levels of the hematopoietic hierarchy. In transgenic mice we show that the expression of HOXA10 is tightly regulated by doxycycline. Intermediate concentrations of HOXA10 induced a 15-fold i
Although the assembly of a ternary complex between the SNARE proteins syntaxin-1, SNAP25 and VAMP2 is known to be crucial for insulin exocytosis, the mechanisms controlling this key event are poorly understood. We found that pancreatic beta-cells express different isoforms of tomosyn-1, a syntaxin-1-binding protein possessing a SNARE-like motif. Using atomic force microscopy we show that the SNARE
Abstract is not available
Software inspections are regarded as an important technique to detect faults throughout the software development process. The individual preparation phase of software inspections has enlarged its focus from only comprehension to also include fault searching. Hence, reading techniques to support the reviewers on fault detection are needed. Usage-based reading (UBR) is a reading technique, which foc
Identifying mechanisms behind assortative mating is central to the understanding of ecological divergence and speciation. Recent studies show that populations of the freshwater isopod Asellus aquaticus can rapidly become locally differentiated when submerged Chara vegetation expands in lakes. In the novel Chara habitat, isopods have become lighter pigmented and smaller than in ancestral reed stand
Background: Noise is typically conceived of as being detrimental to cognitive performance. However, given the mechanism of stochastic resonance, a certain amount of noise can benefit performance. We investigate cognitive performance in noisy environments in relation to a neurocomputational model of attention deficit hyperactivity disorder (ADHD) and dopamine. The Moderate Brain Arousal model (MBA;
Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this
Low-grade fibromyxoid sarcoma (LGFMS) is a distinctive fibroblastic neoplasm that is characterized by alternating collagenous and myxoid areas, deceptively bland spindle cell morphology, a whorling architecture, and a t(7;16) translocation involving FUS and CREB3L2. Owing to variable morphology and a lack of discriminatory markers, LGFMS can be difficult to distinguish from benign mesenchymal tumo
