The evolution of respiratory chain complex I from smaller functional modules
Popular Abstract in English The cell is the basic unit in all organisms. The molecular machinery in cells converts the energy in sunlight or food into a form of energy that the cell can use for physiological processes in the organism. In humans, this molecular machinery is located in the mitochondria; therefore they are often called the power plants of the cell. The molecular machines are actuallyNADH:quinone oxidoreductase, or complex I, is a large membrane bound enzyme in the respiratory chain of living organisms, that has evolved from the combination of smaller functional building blocks. The enzyme has a conserved core structure, comprising 14 protein subunits: Seven subunits protrude from the membrane and contain a flavin and eight iron-sulfur clusters. The remaining seven subunits in
