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BACKGROUND: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). METHO
The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles
BACKGROUND.: To better define subpopulations in which achieving adequate mycophenolic acid (MPA) concentrations quickly would be important, a post hoc exploratory analysis on the fixed-dose concentration-controlled database was performed, comparing high- versus low-risk renal transplant patients. METHODS.: Renal transplant patients were treated with mycophenolate mofetil, corticosteroids, and cycl
Popular Abstract in Swedish Att vara äldre, beroende av hjälp och leva med varaktig smärta. För äldre människor som är beroende av hjälp från omvärlden för att klara av sitt dagliga liv, utgör inte bara den nedsatta funktion ett problem. Många är drabbade även av andra problem, varav ett vanligt är ihållande och varaktig smärta. För vissa äldre med gravt nedsatt funktion kan språket ha drabbat's This thesis explores everyday living with persistent pain from the perspectives of functionally dependent older persons in pain and of staff. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and tools for assessing pain. The first data collection included 66 persons (65+) living in sheltered accommodation and their corresponding contact nurses.
Introduction: This thesis explores the integration of EEG into wearable devices, emphasizing its evolution from clinical to non-clinical settings and its significance in depression treatment. Method: Employing three EEG systems (Emotiv EPOC Flex, IDUN Guardian, and OpenBCI Cyton), the study investigates their efficacy in non-clinical environments. Experiments focused on optimal brain region identi
This research aims to examine the effects of the new LNG network structure on EU’s energy security. The research question is as follows: How can the concept of Weaponized Interdependence (WI) inform EU’s Energy Security? The concept of WI is used to reveal structural positions in the network which can be utilized to leverage political means. In addition, this research adopts a reinforcing understa
The quality inspection of wooden boards is experiencing a large change. By the use of camera and laser technology board characteristics and defects can be instantly identified and measured. This thesis investigates how the information from a quality inspection system can be used to classify boards into different quality classes, by the use of statistical classification models. Two types of classif
Child poverty is a growning issue in the Swedish society today. Research in the area demonstrates differences in support and intervention work around Sweden, which appose the principle of equality that underpin Swedish welfare policy. Combating child poverty is a shared concern between different political actors. It does not in itself constitute a specific policyarea. But it is linked to activitie
The aim of this single-site, open-label clinical trial was to determine the biodistribution, pharmacokinetics, absorbed doses, and safety from 2 sequential weight-based administrations of Ra-223-dichloride in patients with bone metastases due to castration-refractory prostate cancer. Methods: Six patients received 2 intravenous injections of Ra-223-dichloride, 6 wk apart, at 100 kBq/kg of whole-bo
Plasma fibrinogen concentration is important for coagulopathy assessment, and is most commonly measured using the Clauss method. Several factors, including device type and reagent, have been shown to affect results, The study objective was to evaluate performance and repeatability of the Clauss method and to assess differences between measurements performed during and after cardiopulmonary bypass
Abstract The overall aim of this thesis was to increase knowledge about underlying causes and perioperative risk factors of Acute Confusional State (ACS) in elderly patients with hip fracture and to investigate the effect of a multi-factorial intervention program in order to decrease the number of patients who develop ACS. The aim in paper I was to describe elderly patients with hip fracture on th
Sexual and Reproductive Health and Rights (SRHR) is suggested to be solved by policies and action plans. However, post-structural scholars argue that discourses shape policies, and their solutions. The policy discourse on women with disabilities’ SRHR needs has not been given much attention, especially in the context of Africa. Therefore, this study questions how SRHR is represented in relation to
Tauopathies belong to a group of neurodegenerative diseases that are characterized by the presence of neurofibrillary tangles in neurons and includes diseases such as Alzheimer´s disease and frontotemporal dementia. Neurofibrillary tangles are insoluble deposits that are composed mainly of tau, which normally acts to stabilize microtubules. In disease, tau forms fibrillar and oligomeric species, w
The 36-hectare large RWN Areal is located 2 km south of the city center of Neubrandenburg, Germany. What once was founded as a Torpedo Testing Facility during WWII, became a Military Repair Work Facility during the GDR government until 1990. After the German Reunification, the site has only served business and industrial purposes, but was more so neglected in the 2000s and became a blind spot ever
The purpose of the research thesis is to examine which steps are evident in the development of innovations in family businesses, and to determine which steps of the innovation process are affected by traditions and knowledge. An abductive method was used for the thesis, together with a qualitative research consisting of interviews with respondents from the two case study companies Engelholmsglass
