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OBJECTIVE - Low-grade chronic inflammation has been hypothesized to underlie the constellation of cardiometabolic risk factors, possibly by inducing insulin resistance. In the present study, we investigated associations between inflammation markers, insulin sensitivity (expressed as the ratio of the M value to the mean plasma insulin concentrations measured during the Final 40 min of the clamp [M/

AMP-activated protein kinase (AMPK) is a key molecular regulator of cellular metabolism, and its activity is induced by both metformin and thiazolidinedione antidiabetic medications. It has therefore been proposed both as a putative agent in the pathophysiology of type 2 diabetes and as a valid target for therapeutic intervention. Thus, the genes that encode the various AMPK subunits are intriguin

The objective of this study was to investigate whether the appearance of virtual human models influences observers when judging a working posture. A task in which a manikin is manually assembling a car battery was used in the experiment. In total, 16 different Pictures were presented to the subjects. All pictures had the same background, but included a unique posture and manikin appearance combina

Swedish emergency services still have relatively limited resources and time for proactive fire prevention. Because of this, there is an extensive need for strategic working methods and knowledge to take advantage of spatial analyses. In addition, decision-making based on visualizations and analyses of their own collected data has the potential to increase the validity of strategic decisions. The o

Paperboard mechanical properties at fracture during uniaxial tests is an interplay between available elastic energy at fracture and the fracture energy needed to separate the sample into two parts. A test at a critical length, the load vs. elongation curve immediately falls from a point of instability to zero load. Whereas, a test at a stable length give a stable descending load-elongation curve wPaperboard mechanical properties at fracture during uniaxial tests is an interplay between available elastic energy at fracture and the fracture energy needed to separate the sample into two parts. In a test at a critical specimen length, the load vs. elongation curve immediately drops from a point of instability to zero load, whereas a test at a stable length gives a stable descending load-elonga

This thesis aims to develop new synthetic methods and explore the possibilities to apply it in the total synthesis of natural products.Chapter 2 deals with a mild procedure for the synthesis of a-keto amides by a-oxidation of the corresponding aketo amines mediated by pyrrolidine and TEMPO. The method can also be applied to the synthesis of a-keto thioamides and a-keto amidines.Chapter 3 deals wit

OBJECTIVES: To study evidence for construct validity, the aim was to describe the outcome from the recently developed Diabetes Questionnaire, assess the associations of that outcome with clinical variables and generic health-related quality of life, and study the sensitivity to differences between clinically relevant groups of glycaemic control in adults with type 1 and type 2 diabetes in a nation

Background: Being able to discriminate between HIV-1, HIV-2 and HIV-1/2 dual infection is imperative for the appropriate selection of antiretroviral therapy (ART) in regions with high HIV-2 endemicity. Objectives: To evaluate Bio-Rad Geenius HIV-1/2 Confirmatory Assay against INNO-LIA HIV 1/2 Score and ImmunoComb HIV 1/2 BiSpot with an emphasis towards ability to discriminate between HIV-1, HIV-2

Microbial decomposers process a great majority of net primary production in the biosphere and regulate carbon (C) and nutrient cycling. Microbial communities are extremely diverse and often disregarded from global C-cycling models, but one strategy to overcome this challenge is to focus on the major decomposer groups: fungi and bacteria. These groups have distinct life strategies and are differentMicrobial decomposers process a great majority of net primary production in the biosphere and regulate carbon (C) and nutrient cycling. Microbial communities are extremely diverse and often disregarded from global C-cycling models, but one strategy to overcome this challenge is to focus on the major decomposer groups: fungi and bacteria. These groups have distinct life strategies and are different

Questions concerning children’s place in a worshipping community keeps reemerging in the Church of Sweden, as well as in other churches. Often ideals of inclusivity and children’s participation collide with ideals of a solemn, calm and “adult” liturgy. Children might simultaneously be seen as carriers of hope and a special proximity to God and as disturbers: they make noise and are “too young to u

Introduction: The extent to which pain is distributed across the body (spreading of pain) differs largely among patients with chronic pain conditions and widespread pain has been linked to poor quality of life and work disability. A longer duration of pain is expected to be associated with more widespread pain, but studies are surprisingly scarce. Whether spreading of pain is associated with clini

Introduction: This multicenter, prospective observational study aimed to evaluate the performance of the StatStrip® Lactate 2 (Nova Biomedical, Waltham, US) point-of-care device for fetal blood lactate measurement and to determine the corresponding lactate value equivalent to the established intervention cutoff used with the outgoing StatStrip® Lactate device. Material and Methods: The study was c

This contribution deals with a specific ritual expression among the Sámi, the bear grave. Brown bears were sacred in the Sámi society. They were hunted, killed, and then consumed during a feast. All bones of the killed bear were afterwards collected and carefully buried. At present, in the Swedish part of Sápmi, we have evidence of definite Sámi bear graves going back in time for one thousand year

Previous research has focused on how governments and public authorities can limit civil society organisations’ (CSOs) autonomy by shrinking their operational civic space and their democratic functions. There has been less attention paid to how other external actors and types of pressure might restrict access to civic space and how it can induce coping responses on both an individual and organizati

This article presents a search for new resonances decaying into a Z or W boson and a 125 GeV Higgs boson h, and it targets the νν¯ bb¯ , ℓ+ℓ−bb¯ , or ℓ±νbb¯ final states, where ℓ = e or μ, in proton-proton collisions at s = 13 TeV. The data used correspond to a total integrated luminosity of 139 fb−1 collected by the ATLAS detector during Run 2 of the LHC at CERN. The search is conducted by examin

Visions, or revelations, played an enormously important role in late medieval society. So much so that the question what constituted an authentic vision was debated at the highest ecclesiastical levels. Furthermore, the majority of visionaries in this period were women, and visions afforded them with unique opportunities to exercise their abilities in contexts otherwise almost exclusively reserved