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Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis differences between patients with sporadic and Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S PD, the most common monogenic form. Here we used bio-orthogonal non-canonical amino acid tagging for global analysis of newly translated proteins in fibro
BACKGROUND: In experimental animal studies, exposure to general anesthesia in early childhood may results in changes in infant brain morphology and behavior, potentially leading to the development of autistic behaviors in the long-term. However, in clinical studies the role of exposure to general anesthesia in early childhood and the risk of autism is unknown. METHODS: This is a population-based c
ObjectiveGestational diabetes mellitus (GDM) is an established risk factor for developing type 2 diabetes mellitus (T2DM) that is possible to prevent by systematic follow-up and preventive measures. The aim of this study was to examine whether women with previous GDM were offered follow-up in primary care, according to Swedish national guidelines.DesignRetrospective review of electronic medical re
Diglyphus Walker, 1844 (Hymenoptera: Eulophidae) is an economically important genus including species acting as biocontrol agents against agromyzid leafminer pests. A new species of Diglyphus, Diglyphus difasciatus Liu, Hansson & Wan, sp. nov., was discovered during the identification of agromyzid leafminers and their associated parasitoid wasps collected from 2016 to 2022 in China, based on m
Objectives To examine the association between cultural attendance and all-cause mortality. Design A longitudinal cohort study over 36 years (1982-2017) with three 8-year interval measurements of exposure (1982/1983, 1990/1991 and 1998/1999) to cultural attendance and a follow-up period to 31 December 2017. Setting Sweden. Participants The study included 3311 randomly selected individuals from the
Moral economy studies have investigated public opinion as to who should get what and why, and concluded that older people constitute a group that is perceived to deserve and be in need of support from society. A weakness of the approach is that the category of older people is taken for granted and specific age-limits are left unproblematized. The present study investigates views among municipal ne
SCOPE: Evidence suggests a positive association between ultra-processed food (UPF) consumption and the incidence of cardiovascular disease (CVD). We aimed to investigate associations between UPF intake and respiratory disease, CVD, and their multimorbidity in a large prospective cohort.METHODS AND RESULTS: Within the UK Biobank, participants who were free from respiratory disease or CVD at baselin
Objective: Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) has previously shown alterations in cerebral perfusion in patients with systemic lupus erythematosus (SLE). However, the results have been inconsistent, in particular regarding neuropsychiatric (NP) SLE. Thus, we investigated perfusion-based measures in different brain regions in SLE patients with and without NP invo
Eutrophication or the nutrient enrichment of water bodies, typically by nitrogen and phosphorus has adversely affected the aquatic life and the quality of water. Governments have been forced to take actions in order to reduce the release of these nutrients into the environment. To date the main global effort has been to remove such nutrients at source. However, with an increase in awareness of the
The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney mal
The cDNAs encoding human prostatic acid phosphatase were cloned and characterized. The mRNAs contain 3' noncoding regions of heterogeneous sizes 646, 1887 or 1913 nucleotides. A dimer and a monomer of the conserved Alu-repeats are present in the longer 3' noncoding sequences. The complete sequence of 354 amino acids for the mature enzyme was determined by sequencing both cDNA and protein. Human pr
Legacy streamer data and newer 3D ocean-bottom-cable data are cross-matched and analysed for time-lapse analysis of geomechanical changes due to production in the Valhall Field. The issues relating to time-lapse analysis using two such distinctly different data sets are addressed to provide an optimal cross-matching workflow that includes 3D warping. Additionally an assessment of the differences b
Popular Abstract in Swedish Synergonomiska bedömningar och interventioner genomfördes på icke-dator relaterade arbetsuppgifter vid återvinningsanläggningar, postsorteringsanläggningar och i operationssalar. Resultaten kan i viss mån tillämpas på andra yrken och arbetsplatser. Syftet med forskningen var att undersöka vilken påverkan synergonomiska interventioner hade vad gällande ögonbesvär, muskulVisual ergonomics evaluations and interventions were performed on non-computer work tasks at recycling facilities, post sorting facilities and operating theatres. The results can to some extent be applicable to other professions and workplaces. The purpose of the research was to investigate the effects of visual ergonomics interventions on eyestrain, musculoskeletal discomfort, headache, and visua
