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HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-specific T cell responses common in slower progressors. Lower virus evolutionary rates, and positive selectio
The latest Gaia data release enables us to accurately identify stars that are more luminous than would be expected on the basis of their spectral type and distance. During an investigation of the 329 best solar twin candidates uncovered among the spectra acquired by the GALAH survey, we identified 64 such overluminous stars. In order to investigate their exact composition, we developed a data-driv
We have identified a first group of 33 new candidates for symbiotic stars (SySt) of the accreting-only variety among the 600 255 stars so far observed by the GALactic Archaeology with HERMES (GALAH) high-resolution spectroscopic survey of the Southern hemisphere, more than doubling the number of those previously known. GALAH aims to high latitudes and this offers the possibility to sound the Galax
BACKGROUND: The number of people with lifestyle-related diseases continues to increase worldwide. Improving lifestyle behavior with health literacy may be the key to address lifestyle-related diseases. The delivery of educational videos using mobile health (mHealth) services can replace the conventional way of educating individuals, and visualization can replace the provision of health checkup dat
The Swedish Stroke Register (Riksstroke) was founded in 1994. Riksstroke includes registration of acute stroke, with a follow up after 3 months and 1 year. The Stroke policy and quality register research group has several ongoing projects based on data from Riksstroke, and in many studies also using data record linkage to other national registers and data bases. The thesis of Teresa Ullberg expl
Bacterial infections spanning from local wound infections, affecting patients with non-healing leg ulcers, postoperative wounds or burns, to severe infections and sepsis, are significant medical problems. Today's anti-infective treatments do not address the excessive activation of inflammatory pathways during infection and sepsis, and resistance problems are increasing. Hence, there is a huge unm
Our research uses advanced technology to generate neurons from novel cell sources with the aim to extensively define the subtype and function of the generated neurons and their potential for therapeutic use in the future. For this we are using reprogramming technology in animal models or human stem cell culture system, together with electrophysiology, RNA sequencing, tracing technologies and cell
This thesis investigates the unique queer male engagement with the podcast My Dad Wrote a Porno and its source material, the erotic novella Belinda Blinked. While gay or bisexual males are never present in the fictional story in the book series, queer male fans are amongst the most outspoken in online communities dedicated to the show. The matter of representation of queer males in media is a curr
Due to its proximity, the Orion star forming region is often used as a proxy to study processes related to star formation and to observe young stars in the environment they were born in. With the release of Gaia DR2, the distance measurements to the Orion complex are now good enough that the 3D structure of the complex can be explored. Here we test the hypothesis that, due to non-trivial structure
Introduction: The V beta 12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) beta-chain and consequently displays an increased immunity to CII and increased susceptibility to CIA. However,
BioMS is the national infrastructure for biological mass spectrometry (MS). BioMS offers access to qualified projects in proteogenomics, targeted protein quantitation, glycoproteomics, hydrogen-deuterium exchange MS, glycomics, lipidomics, and chemical proteomics. Detailed information and the project application forms can be found at www.bioms.se. BioMS is hosted by Lund University with support fr
Understanding and therapeutic targeting of lysosome-dependent cell death 1. Deciphering the molecular machinery of lysosome-dependent cell death and its interactions with other cell death and survival processes 2. Understanding the role of lysosomes in diseases with altered cell death 3. Therapeutic modulation of lysosome-dependent cell death 4. Development of novel tools and methods for study
Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionna
This project aims to develop incretin therapy as a glucose-reducing strategy in type 2 diabetes (T2D). Its particular focus is to understand the mechanisms of incretin therapy and to optimize its clinical positioning. This mission is achieved by an interdisciplinary approach with complementary studies in subjects with T2D, healthy volunteers and experimental animals.
This thesis investigates the practices and mobilities of the Danish OpenStreetMap community in order to understand how open-source mapping affects the problem-solving capacity. In more detail, my research challenges the perception of maps as ideal representations of the environment. Instead, it stresses the importance of mapping and the role of the mapper, who moves in a hybrid space, encountering
The laboratory consists of a XenX x-ray irradiator (XStrahl) for experimental radiobiology, with supporting equipment for cell culture applications, such as laminar flow cabinets, CO2 incubators, and a hypoxia workstation. The XenX unit is designed as a radiotherapy machine in miniature. It consists of a 225 kV x-ray source, mounted on a rotatable gantry allowing irradiation of specimens from all
