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Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes

Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei

Lab-scale versus industrial-scale thermal runaway tests for lithium-ion battery cells

Lithium-ion battery safety is a topic of large importance, and testing is associated with large costs. Safety evaluation is therefore needed also at an early stage in cell design and development, in order to evaluate potential short-comings or to screen large platforms of materials and cells. Previous thermal runaway tests on lab-scale cells have, however, indicated differences in heat release and

Untitled

Untitled Master’s Dissertation Structural Mechanics JUAN CARDENAL BASTÉ Report TV SM -5150 JU A N C A RD EN A L BA STÉ D ESIG N M ETH O D FO R STR U T-B EA M C O N N EC TIO N IN H IN G ED FR A M ES DESIGN METHOD FOR STRUT-BEAM CONNECTION IN HINGED FRAMES Detta är en tom sida! Copyright © 2012 by Structural Mechanics, LTH, Sweden. Printed by Media-Tryck LU, Lund, Sweden, July, 2012 (Pl). For inform

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5150.pdf - 2026-05-04

Energy Storage & Conversion

Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r

https://www.energy.lth.se/research/energy-storage-conversion - 2026-05-05

Resultat

Så går det för Sveriges olika fågelarter För ett stort antal fågelarter går det att beräkna en populationstrend som visar om en art ökat eller minskat i antal. Tidsseriens längd varierar mellan arterna och våra olika program, men för flera arter har vi data från 1970-talet och framåt. De kortaste serierna har data från 2015 och framåt.Trenderna beräknas med en statistisk metod som kallas TRIM.Våra

https://www.fageltaxering.lu.se/resultat - 2026-05-05

Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q

Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Surface proteins of pathogenic streptococci

Popular Abstract in Swedish Grupp B streptokocker (GBS; Streptococcus agalactiae) är den vanligaste orsaken till livs-hotande infektioner hos nyfödda barn. Enbart i USA orsakar GBS ~10 000 fall av meningit (hjärnhinneinflammation), pneumoni (lunginflammation) och sepsis (blodförgiftning) varje år. Infektionerna har hög dödlighet och en stor del av de barn som överlever infektionerna får bestående Streptococcus pyogenes (group A streptococcus) and the group B streptococcus (GBS) are two important human pathogens that cause different types of diseases and express different surface structures implicated in virulence. This thesis focuses on several surface proteins expressed by these pathogens, analyzing the biological function of these proteins and their ability to elicit protective immunity.

Ulrika Liljeholm Rapport 0

376969_OMSL_Liljeholm rapport.indd Stöd till unga vuxna med psykisk ohälsa i deras karriärmål och övergång till arbete och studier ULRIKA LILJEHOLM INSTITUTIONEN FÖR HÄLSOVETENSKAPER | MEDICINSKA FAKULTETEN | LUNDS UNIVERSITET 1 Stöd till unga vuxna med psykisk ohälsa i deras karriärmål och övergång till arbete och studier Ulrika Liljeholm 2 Omslagsfoto: Ulrika Liljeholm Lunds universitet, Medicin

https://www.cepi.lu.se/sites/cepi.lu.se/files/2024-12/Ulrika%20Liljeholm%20rapport_0.pdf - 2026-05-05

Calculation and Measurement Methods for the Performance of Solar Collectors. Models of Flat Plate Collectors, Transparent Insulation and Efficiency Factors.

Popular Abstract in Swedish Denna avhandling handlar om modeller för plana solfångare, transparent isolering och verkningsgradsfaktorer. En ekvation för energiutbytet från en glasad plan solfångare härleds genom att modellera verkningsgradsfaktorn, F´, som en summa av en konstant och en temperaturberoende del. Ett alternativt sätt att testa en plan solfångare, baserat på denna modell, föreslås. EThis thesis deals with models of flat plate collectors, transparent insulation and efficiency factors. An equation for the energy output from a glazed flat plate collector is derived by modelling the collector efficiency factor, F´ as the sum of a constant and a temperature dependent part. An alternative way of testing a flat plate collector, based on this model, is suggested. A complete set of a