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E. coli continues to be a popular host organism for production of recombinant proteins. To obtain a high volumetric productivity at the cultivation stage, it is important to achieve a high cell density and a high specific productivity per cell. In many fed-batch processes, the substrate feed rate eventually becomes limited by the oxygen transfer capacity of the bioreactor. While biomass can contin
In an attempt to identify novel susceptibility genes predisposing to early-onset diabetes (EOD), we performed a genome-wide scan using 433 markers in 222 individuals (119 with diabetes) from 29 Scandinavian families with ≥2 members with onset of diabetes ≤45 years. The highest nonparametric linkage (NPL) score, 2.7 (P < 0.01), was observed on chromosome 1p (D1S473/D1S438). Six other regions on chr
Female students' traditional and non-traditional choices of education is the subject of this study. Facing difficult choices on different levels of the educational system girls often, statistically, make traditional choices, but they also in different ways break traditional patterns. The study takes its starting-point in the following issues: What is the girls' understanding of the formal liberty
All ethnic groups have norms and values according to which one is expected to behave. Immigrants in particular have personal networks that simultaneously consist of co-ethnics and friends of a different ethnic background. As a consequence, they may be accustomed to the behavior, norms, and values of their own ethnic group, and also be expected to behave according to those of another ethnic group.
Environmental regulations are continuously pushing lower emissions with an impact on the combustion process in gas turbines (GTs). As a consequence, GT combustors operate in very lean regimes (i. e., at relatively low temperature) to reduce NOx formation. Unfortunately, stabilization becomes a challenge for these lean premixed flames. The extremely unsteady dynamics of swirl stabilized flames pres
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polym
Spinal disorders and especially back and neck pain affect more people and have greater impact on work capacity and health-care costs than any other musculoskeletal condition. One of the difficulties in reducing the burden of spinal disorders is the wide and heterogeneous range of specific diseases and non-specific musculoskeletal disorders that can involve the spinal column, most of which manifest
Background: The consumption of sugar-sweetened beverages (SSBs), which has increased substantially during the last decades, has been associated with obesity and weight gain. Objective: Common genetic susceptibility to obesity has been shown to modify the association between SSB intake and obesity risk in 3 prospective cohorts from the United States. We aimed to replicate these findings in 2 large
Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings function, massing, and overall form are usually made during the first phase. Considering structural performance requirements during conceptual design enhances interdisciplinary interac
Microglia are ramified cells that exhibit highly motile processes, which continuously survey the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia have long been recognized as a crucial player in generating and maintaining inflammatory responses in the CNS, now it has become clear, that their function are much more diverse, particularly in the healthy brain. The i
Objective: To determine, in a large, multiethnic/multiracial, prospective inception cohort of patients with systemic lupus erythematosus (SLE), the frequency, attribution, clinical, and autoantibody associations with lupus psychosis and the short- and long-term outcomes as assessed by physicians and patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including p
A novel approach to the visualisation of soot is presented. It relies on a combination of laser-induced soot vapourisation and consecutive polarisation spectroscopy. Upon soot vapourisation, molecular fragments (for example, C-2) emerge, and may serve as effective tracers for soot. In this study we demonstrate that saturated polarisation spectroscopy on photoinduced C-2 can be exploited for soot d
Breeding Ospreys were studied in southern Sweden and 13 birds were tracked by satellite telemetry on autumn migration to the African wintering grounds. This was supplemented with studies of migrating birds at Falsterbo and radar trackings From southern Sweden. Females generally left the nest site 2-3 weeks ahead of males and juveniles. Among males, failed bleeders migrated significantly earlier th
In recent years, there has been considerable research effort to determine whether other species exhibit prosocial motivations parallel to those of humans; however, these studies have focused primarily on primates, and with mixed results. We presented captive ravens with a modified prosocial choice task which aimed to address several criticisms of previous methods by including a stringent pretraini
During the winter and spring of 2006, Denmark and Scandinavia faced its most serious crisis since World War II. The conflict started as a Danish newspaper published a number of cartoons, some of which portrayed the prophet Muhammad. After the Danish government rejected their requests to censor the media, Danish Islamists distributed these pictures to some senior political and religious figures in
Objective: To report the outcome after ruptured abdominal aortic aneurysm (rAAA) repair in octo- and nonagenarians from the Swedish Vascular Registry 1994-2014. Material and methods: 2335 intact AAA (iAAA) and 1538 rAAA were identified in patients aged 80 years and older. Crude, long-term, and relative survival data were analysed using the Kaplan-Meier method. Crude survival was calculated includi
The current paper addresses the implications of doing research on socially assistive robots in real homes. In contrast to laboratory studies, studies of robots in their intended natural environments can provide insights into people’s experiences of robots, and if and how a robot becomes embedded and used in people’s everyday life. However, moving robots out of the lab and into real life environmen
Background: We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control compared to the currently recommended diabetes diet in patients with type 2 diabetes. To elucidate the mechanisms behind these effects, we evaluated fasting plasma concentrations of g
Ovid closed his 15-book epic of transformation with the metamorphosis of the poet into his work and his work into its own reception, summed up in the final word: uiuam (‘I shall live’). The prophecy has been self-fulfilling, in that the Metamorphoses has entertained readers and inspired artists in different media for two millennia since the poet’s death in AD 17. Loved for its vast repository of m
