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Problem: There are strong forces from for instance politicians, who want to allow third party access to the district heating market, as has already been done in the electricity and gas markets. But what would be the consequences of a third party access to the district heating market? Will it create a competitive market, and will it be able to put any pressure on the prices? What will be the conseq
Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potential
Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COP
Aims. We study the origin of tail-like structures recently detected around the disk of SU Aurigae and several FU Orionis-type stars. Methods. Dynamic protostellar disks featuring ejections of gaseous clumps and quiescent protoplanetary disks experiencing a close encounter with an intruder star were modeled using the numerical hydrodynamics code FEOSAD. Both the gas and dust dynamics were taken int
UNLABELLED: To clarify the role of the TNFRSF11B gene encoding osteoprotegerin (OPG), in Paget's disease of bone (PDB) we studied TNFRSF11B polymorphisms in an association study of 690 UK subjects and in a worldwide familial study of 66 kindreds. We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.INTRODUCTION: P
AbstractObjectives: Patients with inflammatory rheumatic diseases (IRDs) have higher risk of serious infections than healthy individuals due to their illness, comorbidities and treatments. Streptococcus pneumoniae is responsible for 30-50% of community aquired pneumonia in Europe.The proportion of patients with IRD receiving vaccination against pneumococci is still estimated to be suboptimal. The
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical pr
Background: Totally implantable venous access devices (TIVADs) have improved the quality of life for seriously ill and cancer patients. These devices represent a convenient option when long-term venous access is indicated. The Subclavian and Internal Jugular Veins are the vessels of choice for catheterization [1]. However, if it is not possible to catheterize them, an alternative vein should be so
Background: Serotonin (5-HT) is considered to play a role in pulmonary arterial hypertension by regulating vascular remodeling and smooth muscle contractility. Here, arteries from mice with inducible and smooth muscle-specific deletion of Dicer were used to address mechanisms by which microRNAs control 5-HT-induced contraction. Methods: Mice were used 5 weeks after Dicer deletion, and pulmonary ar
To aid informed health sector decision-making, data from sufficient high quality economic evaluations must be available to policy makers. To date, no known study has analysed the quantity and quality of available Iranian economic evaluation studies. This study aimed to assess the quantity, quality and targeting of economic evaluation studies conducted in the Iranian context. The study systematical
In the pursuit of CO₂-neutral renewable energy solutions, biofuels have emerged as one of the key strategies. However, biodiesel production generates a surplus of crude glycerol (GL), creating a need for efficient valorization pathways. The conversion of GL into value-added chemicals represents a sustainable approach to address this issue. Metal nanoclusters (NCats) embedded within metal-organic f
Background: Enamelin is an enamel matrix protein that plays an essential role in the formation of enamel, the most mineralized tissue in the human body. Previous studies using animal models and proteins from natural sources point to a key role of enamelin in promoting mineralization events during enamel formation. However, natural sources of enamelin are scarce and with the current study we theref
BACKGROUND: Programmed death-ligand 1 (PD-L1) expression on tumor cells is associated with poor prognosis in several malignancies, while partly contradictory and inconclusive results have been presented for colorectal cancer (CRC). This study aimed to evaluate PD-L1 as a prognostic biomarker in CRC by comparing three different antibody clones.METHODS: Patients surgically treated for CRC between Ja
Context. The HD 15337 (TIC 120896927, TOI-402) system was observed by the Transiting Exoplanet Survey Satellite (TESS), revealing the presence of two short-period planets situated on opposite sides of the radius gap. This offers an excellent opportunity to study theories of formation and evolution, as well as to investigate internal composition and atmospheric evaporation. Aims. We aim to constrai
Water structure is crucially important to protein function and catalysis and can be conserved throughout related proteins despite differences in sequence. The complex hydrogen-bonding networks formed by water molecules and protein residues have been studied extensively, and graph-theory-based methods have frequently been used to describe these networks. Although there exist a number of tools which
Extending the service life of existing buildings and their components is essential for slowing resource loops in circular construction. While overall building lifespans are relatively well understood, the actual service lives of individual components remain underexplored due to limited empirical data. This study addresses this gap by analyzing and modeling building component lifespans using real-w
Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma. Methods: This was a longitudinal, cohort study across 22 countries participating in the International Sever
The world's legal professions have undergone dramatic changes in the 30 years since publication of the landmark three-volume Lawyers in Society, which launched comparative sociological studies of lawyers. This is the first of two volumes in which scholars from a wide range of disciplines, countries and cultures document and analyse those changes.The present volume presents reports on 46 countries,
The spread of invasive pests is increasing due to greater global transportation and climate change-mediated range shifts. In a new community, these invasive species provide a novel resource that native predators or parasitoids can evolve to utilise. For invasive agricultural pests, this could provide top-down control; however, initial attack rates on invasive species in the wild are generally low.
Background and Aims: Substance use disorder (SUD) is related to widespread adverse consequences, including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non-fatal suicide attempt among individuals with SUD by focusing upon aggregate genetic risks and both childhood and past-year env
