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BACKGROUND: Morphologic examination of bone marrow and peripheral blood samples continues to be the cornerstone in diagnostic hematology. In recent years, interest in automatic leukocyte classification using image analysis has increased rapidly. Such systems collect a series of images in which each cell must be segmented accurately to be classified correctly. Although segmentation algorithms have
A multireference second-order perturbation theory using a restricted active space self-consistent field wave function as reference (RASPT2/RASSCF) is described. This model is particularly effective for cases where a chemical system requires a balanced orbital active space that is too large to be addressed by the complete active space self-consistent field model with or without second-order perturb
Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M
Cathepsin E (CTSE), an aspartic proteinase, is differentially expressed in the metaplasia-dysplasia-neoplasia sequence of gastric and colon cancer. We evaluated CTSE in Barrett's esophagus (BE) and cancer because increased CTSE levels are linked to improved survival in several cancers, and other cathepsins are up-regulated in BE and esophageal adenocarcinoma (EAC). A total of 273 pretreatment tiss
Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. Methods The placebo arms of two large, multinational, clinical trials of an HPV6/11/16/18 vaccine were combined. A total
Comprehensive palliative care programs are often implemented on a community level, and to evaluate such interventions, randomization by cluster (community) may be the only feasible method. In trials randomizing individual subjects, the importance of proper concealment has been stressed, In cluster randomized trials, however, concealment of individual patient allocation is often impossible. The fol
1. To investigate further the release, localization and identity of a non-nitrergic mediator of smooth muscle relaxation in the female pig urethra, we studied the effects of drugs acting at alpha 2-adrenoceptors or K+ channels, the effects of capsaicin and chemical sympathectomy, and the actions of several transmitter candidates. 2. Electrical field stimulation (EFS; frequencies above 12 Hz) of sp
BACKGROUND AND PURPOSE: In failed total ankle replacements (TARs), fusion is often the procedure of preference; the outcome after exchanging prosthetic components is debated. We analyzed prosthetic survival, self-reported function, and patient satisfaction after component exchange. Patients and methods We identified patients in the Swedish Ankle Registry who underwent exchange of a tibial and/or t
The combination of glucagon and glucagon-like peptide-1 (GLP-1) has been suggested as an approach to target obesity, since the two hormones have complementary action on body weight. We examined whether complementary action of the two hormones also exist on insulin secretion. Female C57BL/6 mice were injected intravenously with glucose with or without GLP-1, glucagon or the combination of GLP-1 and
Popular Abstract in English N/AAquatic systems worldwide receive large amounts of organic carbon from terrestrial sources. This ‘allochthonous’ organic carbon (AlloOC) affects critical physical and chemical properties of freshwater ecosystems, with consequences for food web structures and exchange of greenhouse gases with the atmosphere. In the boreal region, loadings of AlloOC are particularly high due to leaching from huge or
Popular Abstract in Swedish Avhandlingen berör aktivering av koldioxid genom inskjutningsreaktioner i palladium-kol bindningar. Detta har gjorts med komplexen (PCP)PdMe och (PCP)PdCH2CHCH2. Dessa komplex har också använts i katalytisk karboxylering of ZnMe2och tributylallyltenn. Pga. transeffekten är bindningen mellan palladium och metylgruppen kraftigt försvagad vilket visar sig i det långa bindnThe present thesis deals with the activation of CO2 by insertion reactions into palladium-carbon bonds. This has been realised for the complexes {2,6-bis[(di-t-butylphosphino)methyl]benzene}palladium(II)methyl [(PCP)PdMe] and (PCP)PdCH2CHCH2. These complexes have also been used in the catalytic carboxylation of ZnMe2 and Bu3SnCH2CHCH2. Because of trans influence the palladium-methyl bond is severe
This paper presents a summary analysis of data regarding evacuation model users experiences and needs obtained via an online survey. The survey was available in 6 languages: English, German, Chinese, Spanish, Italian and Russian. The different versions allowed the survey to be accessible to an international participant base. The survey was developed by the team at www.Evacmod.net ; an evacuation m
Popular Abstract in Swedish I inledningen till detta arbete ställer jag några frågor, såsom vilka filosofiska och teologiska förutsättningar som påverkar Wingrens teologi, om han är medveten om dessa och är kritisk till dem. Detta är viktigt eftersom huvudsyftet med avhandlingen är att spåra de grundläggande tankeförutsättningarna hos honom. Wingren själv anser att tron är förutsättning för det teThe purpose of this study is to represent and critically analyse the theology of the Swedish theologian and professor in Lund, Gustaf Wingren (1910-2000), with special reference to his confrontational views on the role of theology at the university, in society and in church. The Lundensian school was famous for demonstrating a strictly scientific character of theology as an objective argumentation
Popular Abstract in Swedish Automatisk analys av programkod är ett kärnområde inom datavetenskap. Det mest typiska verktyget inom detta område är en kompilator som översätter källkod till maskinkod, men det finns många likartade verktyg, exempelvis översättning mellan språkdialekter, kontroll av kodkonventioner samt automatisk omstrukturering av kod. Eftersom dessa verktyg gör liknande analyser fiProcessing of programs is a core area in computer science. A compiler that translates source text to machine language is the most well-known kind of tool in this area, but there are numerous other kinds of related applications: source-to-source translators, refactoring tools, reengineering tools, metrics tools, consistency checkers, etc. These tools perform similar analyses and can therefore benef
Objectives: Powder painting is an alternative to solvent-based spray painting. Powder paints may contain organic acid anhydrides (OAAs), which are irritants to the airways and may cause sensitisation. The aim of this study was to determine the prevalence of respiratory symptoms and immunological response among powder painters and to describe the exposure to OAAs. Methods: In all, 205 subjects in 3
Popular Abstract in Swedish Utgångspunkten i den här avhandlingen är det faktum att många av Sveriges kommuner har problem med minskande invånarantal och en skev befolkningsstruktur. Den här typen av utvecklingsmönster medför ofta svårigheter för en kommun att attrahera människor att flytta till kommunen, och att upprätthålla en tillfredsställande kommunal service. I sin förlängning kan detta få nMany of Sweden’s municipal districts show a population decline as well as an uneven population distribution. This pattern is neither desirable nor socially sustainable. Sustainable development is a well-known term often discussed from an ecological perspective. At the same time it is established that social and ecological sustainability are closely linked in several ways. In this dissertation soci
Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat deposits from the former crater lake Steregoiu in a mid-altitude area in the Gutaiului Mountains in NW Romania in order to provide a detailed reconstruction of the vegetational development of the area during the Late-Glacial and Holocene. The bottom sediments are siliciclastic and were deposited probably duri
Patients with multiple myeloma (MM) have an increased risk of fractures. On the basis of small numbers, patients with monoclonal gammopathy of undetermined significance (MGUS) have been reported to have an increased fracture risk. Using population-based data from Sweden, we assessed the risks of fractures in 5326 MGUS patients diagnosed from 1958 to 2006, compared with 20 161 matched controls. MGU
Is has long been established, that views to natural scenes can a have a dampening effect on physiological stress responses. However, as people in Europe, Canada and North America today spent 50-85% of their time indoors, attention might also be paid to how the artificial man-made indoor environment influences these mechanisms. The question that this study attempts to start addressing is therefore
Proteoglycans (PGs) are important macromolecules in mammalian cells, consisting of a core protein substituted with carbohydrate chains, known as glycosaminoglycans (GAGs). Simple xylosides carrying hydrophobic aglycons can enter cells and act as primers for GAG chain synthesis, independent of the core protein. Previously it has been shown that aromatic aglycons can be separated from the sugar resi
