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AIM: The sim of this study was to quantify contributions of mortality from drugs, alcohol and suicide (termed as 'deaths of despair' (DoD)) to changes in life expectancy at birth across sexes and regions in Sweden.METHODS: We obtained annual data on underlying causes of deaths by age, sex and region from the National Cause of Death Register. We constructed abridged life tables for two periods: 200
The urgent need to address climate change and pollution prompts societies worldwide to adopt carbon neutral energy and electrification. To facilitate this, a range of technologies and policies will be needed. Alternatives to traditional power grid reinforcement, such as grid-enhancing technologies and system automation, are particularly attractive due to their potentially low cost and fast deploym
Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 c
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving
Introduction Despite an increasing amount of research related to gender-affirming treatment (GAT) outcomes among transgender and gender-diverse (TGD) people (ie, people who experience discomfort or distress in the misalignment between their gender and sex assigned at birth) in recent years, the evidence base for current recommendations is suboptimal. One contributing factor is the heterogeneity in
Background: The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS313 across different European populations which could influence risk estimation has not been performed. Methods: We explored the distribution of PRS313 across European populations using genotype data from 94,072 females without breast cancer
Road traffic pollution is one of the most important factors among other environmental factors that influence the roadside vegetation. The present research examines the impact of motorway flyovers and at-grade roads on air pollution (PM10, SOx, NOx, and air quality index (AQI)) and roadside vegetation in Dehradun by considering the important biochemical parameters such as chlorophyll, ascorbic acid
PURPOSE: To examine sex differences in health-related quality of life (HRQoL) among patients surgically treated for renal cell carcinoma (RCC) in Sweden, utilizing data from the National Swedish Kidney Cancer Register (NSKCR).METHODS: In this study of 4658 surgically treated RCC patients, data on HRQoL, clinical, demographic, and socioeconomic characteristics were retrieved from the NSKCR for pati
Atmospheric inverse modelling and ecosystem data assimilation are two complementary approaches to estimate CH4 emissions. The inverse approach infers emission estimates from observed atmospheric CH4 mixing ratio, which provide robust large scale constraints on total methane emissions, but with poor spatial and process resolution. On the other hand, in the ecosystem data assimilation approach, the
Mild traumatic brain injury (mTBI) is a frequent but underreported consequence of professional cycling crashes, yet current helmet testing standards primarily simulate head-first impacts, and their representation of real-world head impact scenarios is unclear. This study explores crash typology of professional cycling crashes involving head-ground contact through systematic video analysis of 128 h
Purpose: Electronic patient-reported outcomes (ePROs) are used postoperatively to detect complications through real-time symptom monitoring. This study examines whether alerts triggered through the “Recovery Tracker” (RT), an ePRO system, predict 30-day re-admission or re-operation after lumpectomy. Methods: We retrospectively reviewed breast cancer patients who underwent lumpectomy at a single in
BACKGROUND: Sepsis-induced coagulopathy (SIC) is a scoring system developed for early detection of coagulopathy in sepsis and selection of patients for interventional studies. Our aim was to define the prevalence of SIC in a critically ill population and investigate if SIC at intensive care unit (ICU) admission is associated with morbidity and mortality.METHODS: Patients admitted with septic shock
BACKGROUND:Detection of ischemia and intracranial hemorrhage (ICH) directly after endovascular thrombectomy (EVT) could enable earlier diagnosis and treatment. We evaluated whether post-EVT Sine Spin cone-beam computed tomography (CBCT) on the Siemens ARTIS Icono biplane system at the end of the procedure can predict ischemia and ICH on subsequent follow-up computed tomography (FUCT) within 48 hou
Background: First-line managers in healthcare operate in increasingly complex environments marked by high demands, rapid change, and limited resources. These conditions impact their health, leadership capacity, and the sustainability of their roles. While previous research has addressed various aspects of leadership in healthcare, there is a lack of studies focusing specifically on how first-line
Introduction: Cervical cancer represents a significant public health challenge worldwide. To improve screening accessibility and participation, we implemented vaginal human papilloma virus (HPV) self-sampling as part of an organized cervical cancer prevention strategy. This study aimed to evaluate the implementation and outcomes of the self-sampling program in a real-world setting. Material and Me
PurposeThis study aims to assess the diffusion and integration of Circular Economy (CE) knowledge across academic disciplines, by examining how CE concepts spread within mainstream academic and disciplinary discourses.Design/Methodology/ApproachCE is conceptualized as a knowledge object, distinguishing between mainstream academic discourse (MAD) and mainstream disciplinary discourse (MDD). The res
