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Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t
The clinical commissioning of beams for neutron capture therapy involves the measurement and analysis of a large amount of data in various geometries and using various detectors. We have attempted methods and considerations common to the radiotherapy field, while particular care and attention is given to the specifics of the field of neutron capture therapy. This chapter provides an introduction a
Introduction: A core element of caring science, is for caregivers to understand and collaborate with patients. Previous research shows that women receiving forensic psychiatric care evoke strong emotions among caregivers, but there is little research on the subject, and increased knowledge about caregivers’ experiences of providing care for female patients in forensic psychiatry, and of balancing
Multilateration, positioning a receiver using pseudodistances to known senders, is a problem with 5G and GNSS positioning applications. In contrast, trilateration uses direct distances and was reformulated as an eigenvalue problem in a recent work, resulting in a very competitive positioning method. This paper extends that reformulation to a more general class of problems subsuming multilateration
The publications of the roof-tiles from Acquarossa, Poggio Civitate and San Giovenale have left a number of issues in need of further discussion. Besides three sections of special character (1, 4, 6) and two concentrated on tile dimensions (3, 5), the article centres around five questions of more general interest: contacts between the early Etruscan/Latial and Campanian terracotta industries (2),
This study aimed to explore how PEth and other commonly used alcohol biomarkers (CDT, AST, ALT, and GGT) respond to regular consumption of what has been generally considered to correspond to low to moderate amounts of alcohol over a 2-week period. A total of 21 voluntary participants (aged 31–69 years) took part in a 2-week drinking study. Group 1 (n = 11) consumed one glass of wine daily (16 g of
Background: The European ALLTogether protocol for childhood acute lymphoblastic leukemia, initiated in Sweden 2019, introduced earlier asparaginase during induction, dexamethasone instead of prednisone for all patients, and omitted anthracyclines from low-risk induction to reduce treatment-related toxicity. Consolidation-1 was based on the Induction 1B-phase developed by the BFM-group, replacing m
In this paper we revisit positioning from Doppler measurements, using techniques from algebraic geometry to produce new theoretical insights and efficient localization algorithms. First, we give a full characterization of the problem, identifying for each problem their minimal configurations, that is the minimum number of receivers and transmitters to have a finite number of solutions. We also stu
This chapter explores key developments in international tax law amid the digitalization of the global economy. It examines challenges in taxing multinational enterprises (MNEs) and the OECD’s reform efforts under “Pillars One and Two”. The current tax system, designed for a pre-digital era, struggles to capture revenue from digital businesses, enabling profit shifting to low-tax jurisdictions and
The technical development, involving digitalization, artificial intelligence, automation, and machine learning, can challenge the current tax system and consequently the means to finance public sector activities in several ways. If technology replaces labor, a tax base that is taxed relatively hard will be replaced by a tax base (capital) that generates less tax revenue, and consequently, less tot
This open access edited volume discusses the impact of digitalization on taxation, using the Swedish welfare state model as a lens through which to examine the disruptive effect of new technologies on traditional tax models. Taking a multidisciplinary approach, it integrates perspectives from economics, law, audit, and public policy to shed light on contemporary challenges in taxation. With Sweden
Importance Substantial improvements in childhood cancer survival have created a critical need to address serious long-term health complications, such as valvular heart disease (VHD). Objective To identify treatment-related risk factors for VHD in a large European cohort of long-term childhood cancer survivors. Design, Setting, and Participants This nested case-control study used data from the PanC
Hand-eye calibration is a common problem in the field of collaborative robotics, involving the determination of the transformation matrix between the visual sensor and the robot flange to enable vision-based robotic tasks. However, this process typically requires multiple movements of the robot arm and an external calibration object, making it both time-consuming and inconvenient, especially in sc
Throughout the last decades, the social responsibility of corporations has undergone significant changes. From revolving around self-regulation, voluntariness, and soft law, the regulatory landscape has expanded to involve harder demands on corporations, such as mandatory sustainability due diligence. This thesis considers these changes as a hardening of Corporate Social Responsibility (CSR), and
BACKGROUNDAndrogen receptor signaling inhibitors (ARSIs) have improved outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC), but their clinical benefit is limited by treatment resistance.METHODSTo investigate the mechanisms of ARSI resistance, we analyzed the whole-genome (n = 45) and transcriptome (n = 31) sequencing data generated from paired metastatic biopsies obt
