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Apolipoprotein M (apoM) is a novel apolipoprotein presented mostly in high-density lipoprotein (HDL) in human plasma, and is exclusively expressed in liver and in kidney. The pathophysiological function of apoM has not yet been elucidated. Apolipoprotein B (apoB), the characteristic apolipoprotein of low-density lipoprotein (LDL), is like apoM, a very hydrophobic protein, and thereafter they both
Popular Abstract in Swedish Sedering vid respiratorbehandling inom intensivvård ? praxis av sedering och patienters minnen, påfrestande upplevelser och psykologiska problem Akut svårt sjuka patienter i behov av respiratorbehandling på en intensivvårds-avdelning (IVA) utsätts för akut stress och diverse obehag från sjukdomen och/eller skadan, behandlingen, andningstuben och IVA-miljön. MinnesstörnThe overall aim of this thesis was to describe and determine intensive care sedation in adult mechanically ventilated patients with the emphasis on patients? memory, stressful experiences and psychological distress. The results are based on a nationwide postal survey (Paper I) including 89 Swedish intensive care units (ICUs) followed by a prospective cohort study (Papers II?IV) conducted over 18 m
Popular Abstract in Swedish Bröstcancer är den vanligast förekommande cancerformen hos kvinnor och årligen drabbas ungefär 6000 kvinnor i Sverige. I de flesta fall uppstår bröstcancer spontant, men viss ärftlighet ligger bakom ca 10 % fallen. Det finns kopplingar till faktorer som ökar risken för bröstcancer. Till riskfaktorer hör bl.a. långvarig exponering för hormoner: tidig mens och sent klimakUnrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. By overexpressing cyclin E in a cell line model system we demonstrate that the capacity of ce
Bolivia, a country located in the center of South America, has in the west part an Andean region, where the Poopó Lake is located. The area has many mineral resources, and thus since thousands of years,mining activity has had a large importance; however, mainly since colonial times, the extraction of these resources has been indiscriminate and the region of the Poopó Lake, has suffered the consequ
This communication reports a theoretical study of the conversion of homocysteine to methionine by methionine synthase. The reaction pathway is based on density functional calculations with large basis sets, including thermodynamic, relativistic, and solvent effects. We find that the suggested SN2 mechanism explains well the experimentally observed reaction rate. The results show that the reaction
Linkage disequilibrium (LD), the nonrandom occurrence of alleles in haplotypes, has long been of interest to population geneticists. Recently, the rapidly increasing availability of genomic polymorphism data has fueled interest in LD as a tool for fine-scale mapping, in particular for human disease loci(1). The chromosomal extent of LD is crucial in this context, because it determines how dense a
Popular Abstract in Swedish Äldre människor har ofta många hälsoproblem som t.ex. svårigheter att gå, se, höra, smärta och inkontinens men hur vanligt det är bland de allra äldsta är lite under¬sökt. De olika hälsoproblemen kan finnas samtidigt och i särskilda mönster men få studier har gjorts om detta. När ett hälsoproblem läggs till ett annat kommer det kanske till en punkt när behov av hjälp ärAim: The aim of this thesis was to investigate type, degree and patterns of health complaints, need for help and health-related quality of life across gender among persons aged 75?105 as well as to identify how patterns of health complaints, gender, age and socio-economic factors related to need for help with daily activities and quality of life (Paper I). The aim was also to investigate the preva
1. We experimentally tested if a multiplicative risk model accurately predicted the consumption of a common mayfly at risk of predation from three predator species in New Zealand streams. Deviations between model predictions and experimental observations were interpreted as indicators of ecologically important interactions between predators. 2. The predators included a drift-feeding fish [brown t
BACKGROUND: Intestinal inactivity leads to atrophic changes and concomitant alterations in the expression of neurotransmitters in the enteric nervous system. In atrophic rat ileum neurones expressing vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) decrease in number while nitric oxide synthase (NOS) expressing neurones increase. Since little is known
The present study addresses the question why there is a positive relationship between nitrogen deposition and potential net nitrogen mineralisation and nitrification in oak (Quercus robur L.) forest soils in south Sweden (Falkengren-Grerup et al., 1998), and how this is related to the carbon mineralisation. We tested three hypotheses based on European studies (Persson et al., 2000a,b) that postula
High spin states in the neutron deficient isotopes Ru90 and Ru91 have been studied in the 2p2n and 2pn exit channels of the reaction Ar-36 + Ni-58 using the 149 MeV Ar-36 beam at VICKSI and the OSIRIS array. By gating the gammagamma coincidences with evaporated neutrons and protons, excited states in Ru90 were identified for the first time and the level scheme of Ru-91 was extended. In both nuclei
Popular Abstract in Swedish Bakgrund För att diagnostisera förändringar i käkbenet är röntgenundersökning av stor betydelse. En bendestruktion blir synlig i röntgenbilden först när relativt stor mängd ben försvunnit. Flera tidigare studier har visat att destruktionen inte ses förrän den påverkar den kompakta yttre delen av käkbenet. Andra studier har däremot visat att destruktionen kan ses tidigaThe aim was to study digital radiography and to evaluate the influence of image processing on digital dental radiographs for the assessment of periapical lesions. In four studies, artificial bone lesions were made periapically and interradicularly in the mandibular premolar and molar regions. In a clinical study, direct digital radiographic images depicting the periapical bone tissue of different
