Search results

The composition of serum proteins is reflecting the current health status and can, with the right tools, be used to detect early signs of disease, such as an emerging cancer. An earlier diagnosis of cancer would greatly increase the chance of an improved outcome for the patients. However, there is still an unmet need for proficient tools to decipher the information in the blood proteome, which cal

Extracellular vesicles derived from mesenchymal stem cells (MSCs) represent a novel approach for regenerative and immunosuppressive therapy. Recently, cytochalasin B-induced microvesicles (CIMVs) were shown to be effective drug delivery mediators. However, little is known about their immunological properties. We propose that the immunophenotype and molecular composition of these vesicles could con

Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome associated with ribosomal gene mutations that lead to ribosomal insufficiency. DBA is characterized by anemia, congenital anomalies, and cancer predisposition. Treatment for DBA is associated with significant morbidity. Here, we report the identification of Nemo-like kinase (NLK) as a potential target for DBA therapy. To id

Hypothesis: The stability of colloidal dispersions in the presence of multivalent ions depends strongly on the electrostatic interactions between the suspended particles. Of particular interest are colloidal particles having dimensions in the nanometric range and with an anisotropic shape due to its high surface area per unit mass, for example clay, which has the key characteristic of a negatively

Experimental and numerical studies were performed to understand the stabilization of lean premixed natural gas/air flames in a gas turbine model combustor which was equipped with a swirl burner, known as the CECOST burner, designed to replicate the flow and flame structures in an industrial gas turbine engine. The operability range, flame stabilization, and flashback were investigated employing si

We present a program to compute polarizabilities of nominal one-electron systems using the Lagrange-mesh method (LMM) (Baye, 2015), that was used by Filippin et al., (2018). A semiempirical-core-potential approach is implemented, ultimately solving a Dirac-like equation by diagonalizing the corresponding Hamiltonian matrix. In order to build the core potential, the core orbitals are obtained from

Hypothesis: Doxorubicin hydrochloride (DX) is widely used as a chemotherapeutic agent, though its severe side-effects limit its clinical use. A way to overcome these limitations is to increase DX latency through encapsulation in suitable carriers. However, DX has a high solubility in water, hindering encapsulation. The formulation of DX with sodium cholate (NaC) will reduce aqueous solubility thro

Low-dimensionality materials are highly susceptible to interfaces. Indeed, intercalation of different chemical species in between epitaxial graphene and silicon carbide (SiC), for instance, may decouple the graphene with respect to the substrate due to the conversion of the buffer layer into a graphene layer. O-intercalation is known to release the strain of such 2D material and to lead to the for

Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on

Background: Reduction of insertion injury is likely important to approach physiological conditions in the vicinity of implanted devices intended to interface with the surrounding brain. New methods: We have developed a novel, low-friction coating around frozen, gelatin embedded needles. By introducing a layer of thawing ice onto the gelatin, decreasing surface friction, we mitigate damage caused b

Wheat bran arabinoxylan can be converted by enzymatic hydrolysis into short arabinoxylo-oligosaccharides (AXOS) with prebiotic potential. Alkali extraction of arabinoxylan from wheat-bran offers advantages in terms of yield and results in arabinoxylan with highly-substituted regions which has been a challenge to hydrolyse using endoxylanases. We show that this hurdle can be overcome by selecting a

We determine a counterexample to strong diamagnetism for the Laplace operator in the unit disc with a uniform magnetic field and Robin boundary condition. The example follows from the accurate asymptotics of the lowest eigenvalue when the Robin parameter tends to − ∞.

Objective: The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. Methods: A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 1998 and December 31, 2012. Cox regression analysis was used to estimate the relat

Instead of featuring a long-awaited convergence process, the second half of the twentieth century witnessed a dramatic income divergence across countries. We propose cultural distance between countries as a determinant of this economic divergence. Cultural similarity makes it easier for societies to interact, learn and adopt from one another. Consequently, cultural differences may lead to economic

This brief note, on the Bundesverfassungsgericht’s Weiss judgment of 5th May 2020, highlights three implications of the German Federal Constitutional Court’s landmark ruling and its constitutional significance with implications for the wider context of Member States’ cooperation in the EU and European integration as a whole. We explain the relevant background of the judgment and argue that the spe

1. Dementia is a clinical syndrome with several causes whichcreates impairments in mental ability, personality, affect andsocialisation.2. Information from family members can be very useful in theearly identification of cognitive impairment.3. Patients presenting with cognitive impairment should be evaluatedfor potentially reversible causes, with a range of laboratorytests and investigations.4. Sh

Apart from microhardness and elastic modulus, the stress-strain relation is another important characteristic that more and more scholars have been trying to extract from nanoindentation. With the development of artificial intelligence and computer technology, a machine learning based method is proposed in this paper to extract stress-strain curve of grey cast iron using sharp nanoindentation. Firs

Building extraction has attracted considerable attention in the field of remote sensing image analysis. Fully convolutional network modelling is a recently developed technique that is capable of significantly enhancing building extraction accuracy. It is a prominent branch of deep learning and uses advanced state-of-the-art techniques, especially with regard to building segmentation. In this paper

Abstrakt. Gradientval av överföringar gör det möjligt att förenkla polarisationsöverföringssekvenser genom att utelämna kemiska skift-återfokuseringspulser. Funktionerna hos en förenklad STEM-sekvens med tre pulser för {1H-13C} polarisationsöverföring har studerats vid 2 Tesla på ett helkropps MR-system med avseende på användning av MR-spektroskopi in vivo. Den observerade signalen ökas genom nett