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A role for antizyme inhibitor in cell proliferation.
The polyamines are important for a variety of cellular functions, including cell growth. Their intracellular concentrations are controlled by a complex network of regulatory mechanisms, in which antizyme (Az) has a key role. Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines. Th
TPMT status determination: The simplest is the most effective? Reply
Integrative taxonomy of New World Euplectrus Westwood (Hymenoptera, Eulophidae), with focus on 55 new species from Area de Conservacion Guanacaste, northwestern Costa Rica
90 species of Euplectrus are treated: 55 newly described, all from Area de Conservación Guanacaste (ACG),and 35 previously described species, of which 20 occur in ACG. Three of the previously described species(E. brasiliensis Ashmead, E. hircinus (Say), E. ronnai (Brèthes)) have unknown status, owing to missing or severely damaged type material. The new species, all authored by C. Hansson, are: Eu
Measuring long radiographs affects the positioning of femoral components in total knee arthroplasty: a randomized controlled trial.
The aim of this study was to investigate if preoperative measurements of the femoral valgus angle (FVA) affected the mechanical alignment, individual component positions and clinical outcome in total knee arthroplasty (TKA).
Somatosensory impairments are common after stroke but have only a small impact on post-stroke shoulder pain.
Objective: To investigate whether somatosensory impairments are more common in individuals with post-stroke shoulder pain than in those without post-stroke shoulder pain and healthy controls. Design: Descriptive analysis of a convenience sample. Participants: Forty-nine individuals with stroke, 24 with and 25 without post-stroke shoulder pain (median age 65 years), and 11 age- and sex-matched heal
The effect of carbon dioxide on growth of juvenile Atlantic cod Gadus morhua L.
A trial was undertaken to investigate how exposure to graded hypercapnia affected the growth performance of juvenile (15-80g) Atlantic cod. Juveniles were grown at 20‰ salinity and 10°C for 55 days under three hypercapnic regimes: low (2±0.9mgL(-1) CO(2), 0.6mm Hg, 1000μatm), medium (8±0.5mgL(-1) CO(2), 2.8mm Hg, 3800μatm) and high CO(2) exposure (18±0.2mgL(-1) CO(2), 6.3mm Hg, 8500μatm). All wate
Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies.
The aim of this study was to explore whether islet cell antibodies (ICA) could be identified in children with newly onset diabetes mellitus but negative for autoantibodies against glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A), insulin (IAA), or any of the three variants with arginine (R), tryptophan (W), or glutamine (Q) at position 325 of the zinc transporter 8 (ZnT8A).
From a reactive to a proactive safety approach. Analysis of medication errors in chemotherapy using general failure types
A better understanding of why medication errors (MEs) occur will mean that we can work proactively to minimise them. This study developed a proactive tool to identify general failure types (GFTs)in the process of managing cytotoxic drugs in healthcare. The tool is based on Reason’s Tripod Delta tool. The GFTs and active failures were identified in 60 cases of MEs reported to the Swedish national a
Pre-Transplant Renal Impairment Predicts Posttransplant Cardiac Events in Patients With Liver Cirrhosis.
Cardiovascular disease and renal impairment are common in cirrhotic transplant candidates. We aimed to investigate potential association between pretransplant renal function impairment and cardiac events after liver transplantation.
Evaluation of seven time-frequency representation algorithms applied to broadband echolocation signals
Time-frequency representation algorithms such as spectrograms have proven to be useful tools in marine biosonar signal analysis. Although there are several different time-frequency representation algorithms designed for different types of signals with various characteristics, it is unclear which algorithms that are best suited for transient signals, like the echolocation signals of echolocating wh
Managing parental groups during early childhood: New challenges faced by Swedish child health-care nurses.
The purpose of this study was to describe child health centre (CHC) nurses' views of managing parental groups during early childhood. All 311 CHC nurses working within the Swedish CHC system in one county were asked to complete a web-based questionnaire. Findings showed that although the CHC nurses were experienced, several found group leadership challenging and difficult. The need for specialized
Progranulin Bridges Energy Homeostasis and Fronto-Temporal Dementia
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) pop
The genome of wine yeast Dekkera bruxellensis provides a tool to explore its food-related properties.
The yeast Dekkera/Brettanomyces bruxellensis can cause enormous economic losses in wine industry due to production of phenolic off-flavor compounds. D. bruxellensis is a distant relative of baker's yeast Saccharomyces cerevisiae. Nevertheless, these two yeasts are often found in the same habitats and share several food-related traits, such as production of high ethanol levels and ability to grow w
Increased Cerebrospinal Fluid Level of Insulin-like Growth Factor-II in Male Patients with Alzheimer's Disease
Probing Single-Photon Ionization on the Attosecond Time Scale
We study photoionization of argon atoms excited by attosecond pulses using an interferometric measurement technique. We measure the difference in time delays between electrons emitted from the 3s(2) and from the 3p(6) shell, at different excitation energies ranging from 32 to 42 eV. The determination of photoemission time delays requires taking into account the measurement process, involving the i
Comparative effectiveness and survival of infliximab, adalimumab, and etanercept for rheumatoid arthritis patients in the Hellenic Registry of Biologics: Low rates of remission and 5-year drug survival
Objective: To compare effectiveness, drug survival, and safety between infliximab, adalimumab, and etanercept, in a nationwide cohort of rheumatoid arthritis (RA) patients. Methods: This study is a prospective cohort study of 1208 active RA patients. Effectiveness, drug survival, and serious adverse events during entire follow-up (median 2.9 years) were monitored. Results: EULAR and CDAI responses
Wide band characteristic mode tracking utilizing far-field patterns
The Theory of Characteristic Modes provides a convenient tool for designing multi-antennas for MIMO applications, as it enables orthogonal radiation patterns to be excited in a given antenna structure. Moreover, the frequency behavior of the modes reveals interesting wideband properties of the structure. However, the tracking of characteristic modes over frequency remains a challenge, especially w
Tz=-1 → 0 β-Decays of 54Ni, 50Fe, 46Cr, and 42Ti and Comparison With Mirror (3He,t) Measurements
We have studied the β decay of the Tz=−1, f7/2 shell nuclei Ni54, Fe50, Cr46, and Ti42 produced in fragmentation reactions. The proton separation energies in the daughter Tz=0 nuclei are relatively large (≈4–5 MeV) so studies of the γ rays are essential. The experiments were performed at GSI as part of the Stopped-beam campaign with the RISING setup consisting of 15 Euroball Cluster Ge detectors.
