HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. H

Dijet events produced in LHC proton-proton collisions at a center-of-mass energy root s = 8 TeV are studied with the ATLAS detector using the full 2012 data set, with an integrated luminosity of 20.3 fb(-1). Dijet masses up to about 4.5 TeV are probed. No resonancelike features are observed in the dijet mass spectrum. Limits on the cross section times acceptance are set at the 95% credibility leve

Aggregation of gold nanoparticles into soluble spherical assemblies using bi-functional ligands i.e., dithiols has recently been demonstrated but with limited control over the size of such assemblies. Herein, we report a new approach to further control the size of water dispersible spherical assemblies by confining gold nanoparticles in tiny oil droplets in water (oil-in-water emulsions) followed

Two new flavonol derivatives, Geranioside A (kaempferol 3-[3-(alpha-rhamnopyranosyl)-4-oxy-5-hydroxy-6-methyl-3,4-dihyropyran-2H -2-pyranoside]) (1) and Geranioside B (quercetin 3-[3-(alpha-rhamnopyranosyl)-4-oxy-5-hydroxy-6-methyl-3,4-dihyropyran-2H -2-pyranoside]) (2), along with 5 known flavonols (quercetin (3), kaempferol (4), quercetin 4'-O-beta-glucopyranoside (5), quercetin 3-O-beta-glucopy

The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence - a major barrier imposed to tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAFV600E-induced senescence in vitro. However, it is still unclear whether Myc has the same role during tumor development in vivo. Using a conditional, compound knock-in model o

Molecular profiles of asynchronous breast cancer metastases are of clinical relevance to individual patients' treatment, whereas the role of profiles in synchronous lymph node metastases is not defined. The present study aimed to assess individual biomarkers and molecular subtypes according to the St Gallen classification in primary breast tumours, synchronous lymph node metastases and asynchronou

Estrogen exerts vasculoprotective effects in different experimental settings through inhibition of vascular smooth muscle cell proliferation, stimulation of nitric oxide production and attenuation of inflammation. Although these estrogen-evoked beneficial effects have been attributed to estrogen receptor α (ERα), also ERβ and the novel ER GPR30/GPER1 probably play significant roles in vascular est

It has been argued that the study of child L2 development can inform different maturational accounts of language acquisition. One such specific proposal was put forward by Meisel (2008) arguing for a cut-off point for (2)L1 type of development at 3-4 years. The paper analyses the longitudinal development of object clitics in child L2 French (L1 Swedish) and compares the developmental sequence in c

Objective: it is not known how acupuncture is used in midwifery care in Sweden and what kind of requirements health-care providers have for midwives and acupuncture training programmes. The aims of this study were to survey indications for the use of acupuncture in midwifery care in Sweden, and to examine the criteria and requirements used for purchase of acupuncture education programmes. Design:

BACKGROUND: Knowledge about the social and economical determinants of prescription is relevant in health care systems like the Swedish one, which is based on the principle of equity, and which aims to allocate resources on the basis of need and not on criteria that are based on social constructs. We therefore investigated the association between patient and health care practice (HCP) characteristi

Cancer in children and adolescents is rare and biologically very different from cancer in adults. It accounts for 1.4% of all cancers worldwide, although this proportion ranges from 0.5% in Europe to 4.8% in Africa, largely because of differences in age composition and life expectancy. In high-income countries, survival from childhood cancer has reached 80% through a continuous focus on the integr

BACKGROUND: Cerebral blood flow (CBF) measurements are helpful in managing patients with traumatic brain injury (TBI), and testing the cerebrovascular reactivity to CO(2) provides information about injury severity and outcome. The complexity and potential hazard of performing CBF measurements limits routine clinical use. An alternative approach is to measure the CBF velocity using bedside, non-in

PURPOSE. Alzheimer disease (AD) and age-related ocular diseases are characterized by inflammation and accumulation of insoluble proteins. We aimed to investigate the detectability and clinical relevance of a panel of AD-related markers, such as Alzheimer peptides and chemokines, in the aqueous humor (AH) samples taken from patients with cataract only, or cataract and 1 other ocular disease. METHOD

Polymeric anion-exchange membranes (AEMs) are critical components for alkaline membrane fuel cells (AMFCs) which offer several attractive advantages including the use of platinum-free catalysts and a wide choice of fuel. The development of AMFCs and other electrochemical energy systems is currently severely limited by the lack of AEMs with sufficient alkaline stability. Still, significant advances

Population-based data on hospital procedure volume and outcome of endoscopic retrograde cholangiopancreatography (ERCP) are limited.

BACKGROUND:: Childhood immunology has been suggested to play a role in development of inflammatory bowel disease (IBD) based on the studies of childhood vaccinations, infections, and treatment with antibiotics. Bacille Calmette-Guérin (BCG) and smallpox vaccinations were gradually phased-out in Denmark for children born between 1965 and 1976, hence allowing the study of subsequent risk of Crohn's

Modeling of loads on a vehicle through Laplace moving averages is extended to the multivariate setting and efficient methods of computing the damage indexes are discussed. Multivariate Laplace moving averages are used as statistical models of multi-axial loads represented by forces and moments measured at some locations of a cultivator. As opposed to models based on the Gaussian distribution, thes