Inhibition of dipeptidyl peptidase 4 (DPP-4) is a novel treatment for type-2 diabetes. DPP-4 inhibition prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby lowering glucose levels. Several DPP-4 inhibitors are in clinical development. Most experience so far has been with sitag

An undergraduate course in Strategic Management seemingly provides similar basic content to students including the infamous SWOT (strengths, weaknesses, opportunities and threat) analysis along with the identification of functional level, business level, and generic strategies to enhance an organization’s competitiveness. One of the most common resources for this type of course is the article outl

This thesis is a study of configurations of identity in American mainstream comics. It focuses on how a small number of writers of Jewish descent have expressed or disciplined their Jewishness in relation to their creations. In an attempt to revise common linear narratives, the thesis presents three case studies of famous and influential comics texts with different primary foci: a chapter on SuperPopular Abstract in English The publication of Michael Chabon’s Pulitzer-prize winning novel The Amazing Adventures of Kavalier & Clay (2000) brought the Jewish–comics connection to popular attention. The novel illuminated the fact that many of the pioneers of American mainstream comics were Jewish. Owing to this history, and to the fact that there today exists a large and growing library of s

We are reporting on a novel approach for structured immobilisation of enzymes on gold surfaces modified with monolayers of functionalised alkylthiols. The formation of enzyme spots is achieved by shooting very small volumes of an appropriate enzyme solution (down to 100 pl) onto a thiol-monolayer modified gold surface using a micro-dispenser. Formation of enzyme patterns is obtained by moving the

A limitation on the extinction cross section, valid for all scatterers satisfying some basic physical assumptions, is investigated. The physical limitation is obtained from the holomorphic properties of the forward scattering dyadic. The analysis focuses on the consequences for materials with negative permittivity and permeability, i.e. metamaterials. From a broadband point of view, the limitation

Kulturartikel om framgången både nationellt och internationellt för den Sydkoreanska filmen i början av 2000-talet.

Kulturartikel om serieromanförfattaren Alan Moore med anledning av filmverrsionen av hans roman Watchmen.

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Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association be

Concrete structures in hydro power plants exposed to harsh environment, such as non-frozen freshwater and long cold winters with freezing temperatures, are always in the danger-zone for suffering from concrete damages. Some existing concrete structures already suffer from different damages caused by high water content. The conditions regarding concrete quality, air entrainment, temperature and tim

BackgroundA suspected occult hip fracture after normal radiography is not uncommon in an elderly person after a fall. Despite a lack of robust validation in the literature, computed tomography (CT) is often used as secondary imaging.PurposeTo assess the frequency and clinical utility of non-cortical skeletal and soft tissue lesions as ancillary fracture signs in CT diagnosis of occult hip fracture

Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysio

Prion protein (PrP) is an endogenous protein involved in the pathogenesis of bovine spongiform encephalopathy and Creutzfeldt-Jakob disease. Murine PrP has been reported to bind C1q and activate the classical pathway of complement in a copper-dependent manner. Here we show that various conformational isoforms (native, amyloid fibrils, and beta-oligomers) of recombinant human PrP (90-231 and 121-23

T cells have been attributed an important role in modulating repair responses following vascular injury. The aim of this study was to investigate the role of different T cell subsets in this context.

Growth from straight cracks is studied, both for loading in pure mode I or II and for mixed mode loading. Small scale yielding and a plane condition are assumed. Growth is assumed to take place in either mode I or mode II. Loss of directional stability sometimes occurs even from cracks that seem destined for continued growth straight forward. A striking example is the case of collinear cracks unde