The clinical onset of type 1 diabetes or autoimmune diabetes occurs after a prodrome of islet autoimmunity. The warning signals for the ensuing loss of pancreatic islet beta cells are autoantibodies against insulin, GAD65, IA-2, and ZnT8, alone or in combinations. Autoantibodies against e.g. insulin alone have only a minor risk for type 1 diabetes. However, progression to clinical onset is increas

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Popular Abstract in Swedish Hur hade vår värld sett ut utan den teknologiska revolutionen som skett de senaste decennierna? Inget internet, inga mobiltelefoner, inga surfplattor? Drivkraften bakom att det hela är en väldigt liten beståndsdel som sitter i nästan all elektronik, den så kallade transistorn. En transistor kan se lite olika ut men är i stora drag en elektrisk komponent där man styr strThis thesis explores several novel material systems and innovative device concepts enabled by nanowire technology. State-of-the-art fabrication techniques such as electron beam lithography and atomic layer deposition are utilized to achieve high control and quality in the device fabrication. The devices in this thesis are based on two main types of design geometries, lateral and vertical, each of

Background/aim: People with profound cognitive disabilities are not expected to learn powered mobility use. The Driving to Learn project focussed on what this population could achieve from practising in a joystick-operated powered wheelchair. By means of using grounded theory methodology an eight-phase process 'growing consciousness of joystick-use' was identified. In addition, a tool for assessme

B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other processes including somatic hypermutation, gene conv

Popular Abstract in Swedish Eld har fascinerat människan i alla tider. Att sitta och värma sig vid en lägereld, sjunga sånger eller bara titta på hur elden rör sig är något de flesta har upplevt. Hur många har egentligen funderat på var värmen kommer ifrån, hur den gula färgen uppstår eller vad eld egentligen består av? Några av frågorna finns det nu svar på, men fortfarande finns det mycket att uThe work presented in the thesis covers the use of laser-induced fluorescence (LIF) and photofragmentation laser-induced fluorescence (PFLIF) with short laser pulses to determine species concentrations in different combustion environments. To attain quantitative species concentrations using LIF investigations of the influence of collisional quenching on the fluorescence signal strength is of vital

Abstract in UndeterminedThis study examined the relationship between speech recognition, working memory and conversational skills in a group of 13 children/adolescents with cochlear implants (CIs) between 11 and 19 years of age. Conversational skills were assessed in a referential communication task where the participants interacted with a hearing peer of the same age and gender. The measures were

Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecularly subtype 577 breast tumors, including 72 breast tumors from BRCA1/2 mutation carriers. Focusing on

Burnets were surveyed in 100 semi-natural pastures in the province of Ostergotland, southeastern Sweden. We analysed the presence/absence of burnets in relation to habitat characteristics, and species richness of butterflies and plants. Five species were found (Adscita statices, Zygaena osterodensis, Z. viciae, Z. filipendulae and Z. lonicerae), all occurring in 33%-36% of the localities. Among th

In the aircraft industry maximizing availability is essential. Maintenance schedules must therefore be opportunistic, incorporating preventive maintenance activities within the scheduled as well as the unplanned ones. At the same time, the maintenance contractor should utilize opportunistic maintenance to enable the minimization of the total expected cost to have a functional aircraft engine and t

Kulturartikel om amerikanska nyinspelningar av framförallt franska men också brittiska biosuccéer.