Leukotriene A4 hydrolase/aminopeptidase (LTA4H) (EC 3.3.2.6) is a bifunctional zinc metalloenzyme with both an epoxide hydrolase and an aminopeptidase activity. LTA4H from the African claw toad, Xenopus laevis (xlLTA4H) has been shown to, unlike the human enzyme, convert LTA4 to two enzymatic metabolites, LTB4 and another biologically active product Δ(6)-trans-Δ(8)-cis-LTB4 (5(S),12R-dihydroxy-6,1

Subtle changes in the geometric and electronic properties of supported molecules, with a potential impact on the functioning of molecular devices, can typically be imaged by scanning probe microscopy, but their exact origin and nature often remain unclear. Here we show explicitly that the symmetry reduction of iron phthalocyanine upon adsorption on Cu(111) can be observed not only in scanning tunn

Background: Currently, the TNM classification of malignant tumours based on clinicopathological staging remains the standard for colorectal cancer (CRC) prognostication. Recently, we identified the mitochondrial oxidative phosphorylation chain as a consistently overrepresented category in the published gene expression profiling (GEP) studies on CRC prognosis. Methods: We evaluated associations of

Popular Abstract in Swedish Känselinformation (sensorisk information) från nacken har stor betydelse för rumsorienteringen. För att kunna detektera kroppsrörelser korrekt och därigenom bibehålla balansen krävs ett samspel mellan nackens sensoriska information tillsammans med kroppens övriga led- och muskelsinnen (proprioceptionen), balansapparaterna i inneröronen (vestibularisorganen), synen samt The overall aim of the work was to examine the influence of cervical biomechanical conditions on movement performance, to study musculoskeletal findings accompanying possible cervicogenic dizziness and to evaluate the influence of cervical proprioception on head orientation. Two devices, measuring cervical range of motion, were compared: Myrin, an inclinometer/compass method and Zebris®, a 3-dime

One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic phenotype. Carbon monoxide (CO), one of the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cancer cells, has been implicated in carcinogenesis and therapeutic resistance. However, the functional contributions of CO and HO-1 to these processes are poorly defined. In human prostate cancers

Felaktigt val av reparationsmetod och reparationsmaterial medför ofta att livslängden hos reparationen blir alltför kort. För att undvika detta måste man ta stor hänsyn till skadeorsaken och till de aktuella miljöpåfrestningarna. Stor hänsyn måste även tas till den skadade konstruktionens återstående kvalitet. I rapporten görs en genomgång av vilka krav som måste ställas på en reparation av olik

Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective

Acute Pancreatitis (AP) is an inflammation disease that characterized by activation of protease and the innate immune system, leading to infiltration of neutrophils and tissue damage in the pancreas. The aim of this thesis was to determine the role of isoprenylation (farnesyltransferase and geranylgeranyltransferase) as well as NET formation in regulating recruitment of neutrophils and tissue dama

Det finns nu forskningsstöd för att arbetstidsförkortning leder till minskad miljöpåverkan. Mycket tyder till och med på att arbetstidsförkortning är en helt central del av en socialt och ekologiskt hållbar klimatpolitik. Det viktigaste sambandet är att arbetstiden påverkar ekonomins storlek, som i sin tur påverkar miljöförslitningen. Även om ekonomins storlek onekligen spelar roll menar författar

Objective. Our aim was to investigate the protective effects of a Lipoxin A(4) analogue (LXA(4)) in the early phase of acute pancreatitis in rats. Materials and methods. Severe acute pancreatitis (SAP) was induced by injection of 5% sodium taurocholate into the pancreatic duct. Rats with SAP were treated with LXA(4) (0.1 mg/kg), 10 min after the 5% sodium taurocholate injection, after which LXA(4)

Aortic smooth muscle cells produce chondroitin/dermatan sulfate (CS/DS) proteoglycans that regulate extracellular matrix organization and cell behavior in normal and pathological conditions. A unique feature of CS/DS proteoglycans is the presence of iduronic acid (IdoA), catalyzed by two DS epimerases. Functional ablation of DS-epi1, the main epimerase in these cells, resulted in a major reduction

We present a quantized model of a harmonically confined dot atom with inherent damping in the presence of a transverse magnetic field. The model leads to a non-Hermitian Hamiltonian in coordinate space. We have analytically studied the effects of damping on Rabi type oscillations of the system. The model explains the decoherence of Rabi oscillations in a Josephson Junction.

In this work, we discuss the possibility of a new approach to measuring oxygen isotope ratios in fossil meteorite samples, specifically one based on nuclear reaction analysis (NRA). Variations of oxygen ratios within meteoritic chromite grains can help to determine the type of meteorite to which the grains originally belonged. In this work, we have evaluated the possibility to use the reaction O-1

Popular Abstract in Swedish Stora resurser används i processindustrin, och i många andra industribranscher, på att rapportera incidenter för att utnyttja erfarenheterna från dessa för att förebygga framtida incidenter – alltifrån mindre störningar till olyckor med stora konsekvenser. Det finns emellertid en hel del som tyder på att man ofta utnyttjar bara en del av hela den potential för lärande sLearning from incidents (from minor disturbances to major accidents) is considered one of the most important ways in the process industry to learn from experiences for improving safety performance. Most companies have a formal incident learning system and considerable resources are used for reporting incidents and for utilising these experiences to prevent future incidents. However, there are many

Background: It is well established that drinking alcohol raises the risk of liver cancer (hepatocellular carcinoma). However, it has not been sufficiently established as to whether or not drinking cessation subsequently reduces the risk of liver cancer and if it does reduce the risk how long it takes for this heightened risk to fall to that of never drinkers. This question is important for effecti

A monograph of the genus Placomaronea is presented; all species described earlier are revised, a total of six species is recognized, and an identification key is presented. In addition to the three previously known species, P. candelarioides, P. lambii and P. mendozae, three new species are described: Placomaronea kaernefeltii is a large rosette-like species known from one locality in northernmost

Objectives: Several studies have suggested that genotoxic risks might still be present in the contemporary rubber manufacturing industry. Previously, we observed elevated levels of urinary mutagenicity and bladder DNA adducts in rubber workers. Presently, we investigated whether DNA adducts in peripheral blood mononuclear cells (PBMC) and/or urothelial cells may be caused by polycyclic aromatic hy