Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells. Such cells display enhanced resistance to standard chemotherapeutic agents and repopulate tumours after therapy. Here we identify the small molecule VLX600 as a drug that is preferentially active against quiescent c

In 2004 at the ATLAS (A Toroidal LHC ApparatuS) combined test beam, one slice of the ATLAS barrel detector (including an Inner Detector set-up and the Liquid Argon calorimeter) was exposed to particles from the H8 SPS beam line at CERN. It was the first occasion to test the combined electron performance of ATLAS. This paper presents results obtained for the momentum measurement p with the Inner De

Phytochemical investigation of the aerial parts of Potentilla astracanica Jacq. led to the isolation of two isoflavonoid glucosides (1, 2) five flavonoid glycosides (3-7) including one flavone-C-glycoside (7) as well as two flavans (8, 9). The occurrence of isoflavonoids and C-glycosyl flavone is being reported for the first time from the genus Potentilla. (C) 2011 Elsevier Ltd. All rights reserve

This paper proposes a technique for undertaking poverty analyses at city level, by studying the implementation of Costa Rica's social housing policy in the medium-sized city of Liberia. The technique was appraised in relation to its capacity to explore the links between social housing, poverty and inequality, the effects of the implementation of the selected policy and the differences between targ

Given the surprise electoral victory in May 2013 of Iranian President Hassan Rouhani, which was attained on a recurrent platform of reform and change, this article seeks to investigate Iran's reform discourse by looking at how it systematically developed under President Mohammad Khatami (1997–2005). Its chief purpose is to delineate the discourse in a retrospective analytical attempt to show why i

Climate change is occurring more rapidly in the Arctic than elsewhere, and is predicted to have a large impact on biodiversity, since entire cold-adapted ecosystems are likely to disappear. Here, we highlight changes in the insect species richness and community composition of wild bees, butterflies and moths over 60 years in an area situated above the tree limit (Padjelanta National Park) in north

Background The hereditary non-polyposis colorectal cancer (HNPCC) subset of tumours can broadly be divided into tumours caused by an underlying mismatch-repair gene mutation, referred to as Lynch syndrome, and those that develop in families with similar patterns of heredity but without disease-predisposing germline mismatch repair mutations, referred to as familial colorectal cancer type X (FCCTX)

This paper characterizes strategy-proof social choice functions (SCFs), the outcome of which are multiple public goods. Feasible alternatives belong to subsets of a product set $${A_{1} imes cdots imes A_{m}}$$ . The SCFs are not necessarily “onto”, but the weaker requirement, that every element in each category of public goods A k is attained at some preference profile, is imposed instead. Admiss

Background: Meniscus extrusion or hypertrophy may occur in knee osteoarthritis (OA). However, currently no data are available on the position and size of the meniscus in asymptomatic men and women with normal meniscus integrity. Methods: Three-dimensional coronal DESSwe MRIs were used to segment and quantitatively measure the size and position of the medial and lateral menisci, and their correlati

Bra inomhusklimat och effektiv energianvändning är av yttersta vikt när nya hus ska byggas. Ny ­teknik har fått ner behovet av energi för uppvärming till ungefär hälften sedan 70-talet. Men elförbrukningen har ökat kraftigt. Här presenterar författarna en systematisk helhetssyn att både spara energi och åstadkomma ett behagligt inneklimat när nya hus utformas eller gamla renoveras. Byggteknik och

During embryonic development and adult life a wide range of cell behaviors such as differentiation, proliferation and migration are in effect to maintain tissue integrity and function. An integral part of these dynamic processes is the interplay between the cells and their environment, i.e. the extracellular space. Complex polysaccharides, such as dermatan sulfate play a key role in these processe

Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal multisystem neurodegeneration targeting central autonomic, olivopontocerebellar and striatonigral pathways, however the underlying mechanisms of neuronal cell death are poorly understood. Prev

Background: With an increased life expectancy for the general population as well as for those ageing with chronic diseases, there are major challenges to the affected individuals and their families, but also to health care and societal planning. Most important, an increasing proportion of older people remain living in their ordinary homes despite health decline and disability. However, little is k

The influence of lithium (Li) exposures on monolayer graphene grown on the silicon-terminated SiC(0001) surface is investigated using low-energy electron microscopy, photoelectron spectroscopy, and micro-low-energy electron diffraction. After Li deposition, islands or Li droplets are observed on the surface, and are found to coalesce together with time. Formation of a dipole layer at the interface

Abstract in Undetermined The aim of this study was to compare the differences between the level of whole quality of life and its subscales after receiving two common treatment of breast cancer in women with early stage of breast cancer. A double-blinded cohort study was done in 100 breast cancer patients with node positive that used fluorouracil, doxorubicin, cyclophosphamide (FAC) and docetaxel,

(Review of) G. Kurt Piehler (ed.), The United States in World War II. A Documentary Reader

Since its establishment, the Android applications market has been infected by a proliferation of malicious applications. Recent studies show that rogue developers are injecting malware into legitimate market applications which are then installed on open source sites for consumer uptake. Often, applications are infected several times. In this paper, we investigate the behavior of malicious Android

Popular Abstract in English My PhD thesis has focused on increasing the understanding of the osteoclasts, the cells responsible for degradation of bone, by studying the rare hereditary disease autosomal recessive osteopetrosis (ARO). ARO is present already at birth and is caused by mutations affecting the osteoclasts ability to degrade bone. Non-functional osteoclasts lead to dramatic increases inThis thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed

Highly resolved vibrational spectra for the Zn-complexes of several meso-substituted tetraarylporphyrins were recorded by fluorescence line narrowing (FLN) method at liquid helium temperature. The frequencies of the vibronic lines of the Zn-5,10,15,20-tetraphenylporphyrin (ZnTPP), the Zn-5,10,15,20-tetramesitylporphyrin (ZnTMesP) and four meso-indolocarbazolyl-substituted porphyrin compounds in th