Measuring pharmacokinetic properties of established and potential PET-tracers
Measuring pharmacokinetic properties is notoriously difficult. The invitro/ex vivo laboratory experiments seek to mimic the physiological responses of the body to the drug, but it rarely gives a good estimate of what happens in vivo. Lipophilicity is traditionally measured by the shake-flask method,in which the distribution of the analyte between two immiscible phases (one organic, one aqueous) is
