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Pharmaceutical co-crystals of the anti-inflammatory drug diflunisal and nicotinamide obtained using supercritical CO2 as an antisolvent

A method based on using supercritical CO2 as an antisolvent (SAS method) is explored as a co-crystallization technique. Co-crystallization is an emerging and powerful technique to improve the physicochemical properties of an active pharmaceutical ingredient. The solid-state and solution co-crystallization methods usually employed present several disadvantages. The one-step SAS method has a low env

The aquaporin splice variant NbXIP1;1α is permeable to boric acid and is Phosphorylated in the N-terminal domain

Aquaporins (AQPs) are membrane channel proteins that transport water and uncharged solutes across different membranes in organisms in all kingdoms of life. In plants, the AQPs can be divided into seven different subfamilies and five of these are present in higher plants. The most recently characterized of these subfamilies is the XIP subfamily, which is found in most dicots but not in monocots. In

To know or not to know – parents’ attitudes to and preferences for prenatal diagnosis

Objective: To highlight expectant parents’ attitudes concerning prenatal diagnosis, what the parents wish to know and what they chose not to know about their unborn baby, also in what form and to what extent they wish for prenatal diagnosis. Background: Parents have to make decisions concerning prenatal diagnosis. Screening programmes change rapidly and there is a need for parental influence on th

Optimal Displacement Parameters in Monte Carlo Simulations

An adaptive algorithm optimizing single-particle translational displacement parameters in Metropolis Monte Carlo simulations is presented. The optimization is based on maximizing the mean square displacement of a trial move. It is shown that a large mean square displacement is strongly correlated with a high precision of average potential energy. The method is here demonstrated on model systems re

Storage stability of freeze-dried, spray-dried and drum-dried skim milk powders evaluated by available lysine

Formation of Maillard products and the influencing factors, which are of crucial importance for both manufacturers and consumers, are still not fully understood. Thus in this study available lysine was used as a marker to monitor the extent of Maillard reactions in freeze-dried, spray-dried and drum-dried skim milk powders during 200 days of storage at highly controlled atmospheres. Storage variab

Analyzing the influence of learning orientation and innovativeness on performance of public organizations : The case of Iran

Purpose – There is growing concern about the performance of public organizations (POs) in developing countries. Despite the fact that the advantages of innovation and learning orientation to organizations have been evidently documented in Western economies and private owned enterprises, there has been little research into these practices and their impact on enhancing competitive advantages in POs

Anomalous temperature behavior in clay swelling due to ion-ion correlations

We show, experimentally and theoretically, that swelling of both natural and refined clays has an anomalous temperature behavior depending on counterion valency. In an aqueous clay dispersion dominated by monovalent counterions the swelling pressure increases with temperature as expected from entropic arguments. In a clay with predominantly divalent counterions, the opposite behavior is found. The

The fan-like forms in the southern margin of the Mazovian Lowland area (Central Poland) : a new high-resolution textural-timing study

An optically stimulated luminescence technique with a high-resolution sampling strategy, as well as a set of multiple proxies such as grain size distribution, shape, surface and microstructures of quartz grains, along with mineral composition of light and heavy fractions was used to investigate the age and origin of fan-like forms at the southern margin of Mazovian Lowland, Poland. The predominanc

Ear-body lift and a novel thrust generating mechanism revealed by the complex wake of brown long-eared bats (Plecotus auritus)

Large ears enhance perception of echolocation and prey generated sounds in bats. However, external ears likely impair aerodynamic performance of bats compared to birds. But large ears may generate lift on their own, mitigating the negative effects. We studied flying brown long-eared bats, using high resolution, time resolved particle image velocimetry, to determine the aerodynamics of flying with

A fast and sensitive method for the separation of carotenoids using ultra-high performance supercritical fluid chromatography-mass spectrometry

In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as we

Microemulsions of Record Low Amphiphile Concentrations Are Affected by the Ambient Gravitational Field

It is shown that the ternary system heavy water-heptane-hexadecyl hexaethylene oxide (C16E6) has a stable bicontinuous microemulsion phase down to an exceptionally low concentration at the balanced temperature of 26.8 °C. It is further demonstrated that the ambient gravitational field has an influence on the observed phase equilibria for typical sample sizes (∼1 cm). Direct measurements using a nu

Online teaching going massive: input and outcomes

The proliferation of massive open online courses is a recent phenomenon in higher education. At the International Institute for Industrial Environmental Economics at Lund University in Sweden, emerging pedagogical approaches in e-learning have long been embraced, allowing for valuable experience with new educational technologies applied in education for sustainability. In 2014, the Institute was g

Pituitary dysfunction after aneurysmal subarachnoid hemorrhage is associated with impaired early outcome

Objective Poor outcome and neuropsychological sequelae after aneurysmal subarachnoid hemorrhage (SAH) is a persistent problem. Pituitary dysfunction has been proposed as a contributing factor. Clinical studies have given variable and conflicting results on its importance and incidence after SAH. The aim of this study was to prospectively examine SAH patients with assessment of endocrine function i

Navigating Information Overload Caused by Automated Testing – A Clustering Approach in Multi-Branch Development

Background. Test automation is a widely used technique to increase the efficiency of software testing. However, executing more test cases increases the effort required to analyze test results. At Qlik, automated tests run nightly for up to 20 development branches, each containing thousands of test cases, resulting in information overload. Aim. We therefore develop a tool that supports the analysis

Using remote sensing to model carbon source/sink dynamics in the sahel

Recent research has identified the grasslands of the Sahel as a potential carbon sink, but regional carbon stock accounting in such biomes is undermined by the poorly recognized role they play in the carbon cycle as well as lack of data. In this paper, we demonstrate the feasibility of coupling the satellite data-driven light use efficiency model (Lund University Light Use Efficiency Model - LULUE

A comparison between the microflora of Herrgård cheese from three different dairies

The microflora of Herrgård cheese produced at three dairies was grouped by phenotypical key tests and typed by randomly amplified polymorphic DNA (RAPD). Ten cheeses from the same vat at each dairy were analysed, five after 3 and another five after 6 months of ripening. All cheeses were organoleptically graded as Herrgård after uniform national standards, and only small but characteristic differen

Neural networks, multitemporal landsat thematic mapper data and topographic data to classify forest damages in the Czech republic

This study uses multitemporal Landsat Thematic Mapper data and topographic data for the purpose of classifying coniferous forest damage in the Czech Republic using an artificial neural network. Comparing the neural network-based classification with earlier studies and a multinominal logistic regression using identical training and test data indicates that the back propagation algorithm is comparab

Heat transfer analysis of a traction machine with directly cooled laminated windings

A directly enhanced cooled winding in an electrical traction machine has the potential to extend the operation range, which is in particular attractive for a traction application when operating near peak power for extended periods of time. This paper presents the heat transfer analysis of a modular machine segment with a laminated winding. The laminated winding has a great potential when it comes