Introduction The Göttingen minipig is a promising model for pharmacological safety assessment and for translational research in cardiology. We have examined the main ion currents in cardiomyocytes of the minipig heart. Methods Cardiac cells were isolated from different cardiac regions (endo-, mid- and epicardial left ventricle and right ventricle) from Göttingen minipigs and examined using the who

Den svenska föreningen för tillämpad språkvetenskap (Association Suédoise de Linguistique Appliquée, ASLA) bildades formellt i april 1966 och firade således 50 år som förening under 2016. Jubileumet uppmärksammades på olika sätt under året. I samband med ASLA-symposiet i Uppsala den 21-22 april 2016 hölls ett panelsamtal på temat om tillämpad språkvetenskap då, nu och i framtiden. I den här texten

This thesis makes a contribution the econometrics of panel data with cross-section dependence (CSD). It consists of five self-contained papers. The most popular approach to account for CSD is to attribute the co-movements of observed variables across entities to unobserved common factors and to estimate these factors via simple cross-section averages of the data. The chapters in this thesis invest

Preeclampsia is a serious pregnancy-specific condition, affecting 10 million women annually worldwide. No specific treatment is currently available. Recent studies have demonstrated abnormal production and accumulation of free fetal hemoglobin in the preeclamptic placenta, and identified subsequent leakage into the maternal circulation as an important factor in the development of preeclampsia. A r

PurposeThe purpose is to provide a structured method for prioritising among the diversity of motives and goals of stakeholders involved in city logistics.Design/methodology/approachThe paper is based on a three-year participant observation study in a city logistics project including ten stakeholders. The data relate to the understanding gained during the three years of study and nine semi-structur

Det finns planer på att bygga ett energilager i berget vid Önneslöv nära Dalby i Skåne. Berggrunden utgörs av en del av Romeleåsen och består huvudsakligen av gnejs med inslag av amfibolit och diabasgångar. Området ligger omedelbart söder om Sydstens stora bergtäkt, där det framgår att berget till stora delar är kraftigt uppsprucket med lervittrade zoner av olika storlek. I samband med byggande geThere are plans to build an energy storage in the rock at Önneslöv near Dalby in Skåne. The bedrock is of a part of Romeleåsen and mainly comprises gneiss, with elements of amphibolite and dolerite intrusions. The area is located immediately south of the Sydsten’s large rock quarry, which shows that the rock is mostly heavily fractured with clay weathered zones of different sizes. In connection wi

Bumble bees are ubiquitous creatures and crucial pollinators to a vast assortment of crops worldwide. Bumble bee populations have been decreasing in recent decades, with demise of flower resources and pesticide exposure being two of several suggested pressures causing declines. Many empirical investigations have been performed on bumble bees and their natural history is well documented, but the un

In Ref. [1], Spencer and Soldatos proposed an enhanced modelling approach for fibre-reinforced composites which accounts for the fibre-bending stiffness in addition to the directional dependency induced by the fibres. Although analytical solutions for simple geometries have been derived over the past years, often subject to specific assumptions such as small deformation kinematics, the application

In Europe an increasing number of scholars from different disciplines show growing interest in studying interactions between society and wildlife. Europe’s diversity with regard to cultures, languages and governance systems for wildlife is reflected in the wealth of research perspectives on human-wildlife interactions. Today a variety of approaches, disciplinary perspectives, theoretical framework

The increasing computational capacity in recent years has spurred the growing use of combustion Large Eddy Simulation (LES) for engineering applications. The modeling of the subgrid stress and flux terms is well-established in LES, whereas the modeling of the filtered reaction rate terms is under intense development. The significance of the reaction mechanism is well documented, but only a few com

Fiber and penton base overproduced in adenovirus (Ad) infected cells can be secreted prior to progeny release and thereby regulate progeny spread. We aimed to investigate the mechanisms of fiber and penton base secretion in Ad2- or Ad5-infected A549 cells. Our flow cytometry analyses detected abundant surface fiber molecules, but little penton base molecules at 12 h post infection. Immunogold stai

Background Exposure to inorganic arsenic increases the risk of cancer and non-malignant diseases. Inefficient arsenic metabolism is a marker for susceptibility to arsenic toxicity. Arsenic may alter gene expression, possibly by altering DNA methylation. Objectives To elucidate the associations between arsenic exposure, gene expression, and DNA methylation in peripheral blood, and the modifying eff

Gastric bypass surgery results in remission of type 2 diabetes in the majority of patients. The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been implicated in the observed remission. Most knowledge so far has been generated in obese subjects. To isolate the surgical effects of gastric bypass on metabolism and hormone responses from

Using a standard model in which the individual consumption path is computed solving an optimal control problem, we investigate central claims of Piketty (2014). Rather than r > g (confirmed in the data) r−ρ>g – with ρ being the rate of time preference – matters. If this condition holds and the elasticity of substitution in the production function is larger than one, the capital share converges to

Rotor-stator mixers (RSMs) can be operated in either batch or inline mode. When operating a rotor-stator geometry in batch mode, it typically experiences an order of magnitude higher volumetric flow through the stator than in inline mode. This is expected to cause differences in the flow and turbulence in the rotor-stator region. This study uses computational fluid dynamics (CFD) to study the hydr

Based on a study of two mediation centers in Sweden, this research shows how mediators encourage victim and offender impression management, regarding looks, attitudes, and speech. It shows how they supervise the emotion work of participants, preparing them for mediation encounters. The author investigates how mediators try to create a “balanced” interaction (e.g., preventing expressed prejudices o

We here investigate the growth mechanism of Sn-seeded GaSb nanowires and demonstrate how the seed particle and its dynamics at the growth interface of the nanowire determine the polarity, as well as the formation of structural defects. We use aberration-corrected scanning transmission electron microscopy imaging methodologies to study the interrelationship between the structural properties, i.e. p

Let (Formula presented.) denote the space of (Formula presented.)-valued analytic functions (Formula presented.) for which the Hankel operator (Formula presented.) is (Formula presented.)-bounded. Obtaining concrete characterizations of (Formula presented.) has proven to be notoriously hard. Let (Formula presented.) denote fractional differentiation. Motivated originally by control theory, we char