Design and Synthesis of D-Galactal-Based Benzimidazole and Benzoxazole Derivatives as Inhibitors of Galectin-8 N-Terminal Domain
Galectin-8 is a β-galactoside-binding protein, participating in many homeostatic and pathological functions, such as regulation of cellular adhesion, T-cell homeostasis, apoptosis, as well as playing a major role in tumor development and progression. Galectin-8 has two CRDs, namely galectin-8 N-terminal (galectin-8N) and C-terminal (galectin-8C) domains, that exhibit differential glycan binding sp
